2-(2'-methoxy-4'-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran - Compound Card

2-(2'-methoxy-4'-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran

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2-(2'-methoxy-4'-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Benzofuran
    • Subclass: Arylbenzofuran
Canonical Smiles COc1cc(O)ccc1c1oc2c(c1)cc(c(c2)O)CC=C(C)C
InChI InChI=1S/C20H20O4/c1-12(2)4-5-13-8-14-9-20(24-18(14)11-17(13)22)16-7-6-15(21)10-19(16)23-3/h4,6-11,21-22H,5H2,1-3H3
InChIKey QZVJJJNZJBVWPG-UHFFFAOYSA-N
Formula C20H20O4
HBA 4
HBD 2
MW 324.38
Rotatable Bonds 4
TPSA 62.83
LogP 5.03
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.2
Exact Mass 324.14
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina addisoniae Leguminosae/Fabaceae Plantae 2590682

Showing of synonyms

  • Na M, Hoang DM, et al. (2007). Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B.. Bioorganic & medicinal chemistry letters,2007, 17(14), 3868-3871. [View] [PubMed]
Pubchem: 44432364
Nmrshiftdb2: 70042807
Bindingdb: 50213493

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(c2)-c3ccccc3

Level: 1

Mol. Weight: 324.38 g/mol

Structure

SMILES: c1coc(c12)cccc2

Level: 0

Mol. Weight: 324.38 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 324.38 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.8
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.630
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.25

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.140
Plasma Protein Binding
68.49
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.860
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
2.060
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.780
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.140
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.880
Rat (Acute)
1.680
Rat (Chronic Oral)
2.500
Fathead Minnow
5.180
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
433.400
Hydration Free Energy
-10.540
Log(D) at pH=7.4
4.220
Log(P)
5.27
Log S
-6.01
Log(Vapor Pressure)
-7.88
Melting Point
182.28
pKa Acid
9.18
pKa Basic
6.77
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9642
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9620
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9578
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9507
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9500
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9447
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9404
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9400
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.9385
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9359
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9295
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.9266
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9209
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9161
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9156
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9127
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9092
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9054
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9049
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8992
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8972
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8915
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8895
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8891
Endochitinase B1 Q873X9 CHIB1_ASPFM Aspergillus fumigatus 4 0.8881
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8870
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8863
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.8839
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8816
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8816
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8791
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8790
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.8781
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8724
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8723
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8710
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8689
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8669
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8633
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8626
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8615
Bifunctional epoxide hydrolase 2 P34914 HYES_MOUSE Mus musculus 4 0.8610
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8609
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8597
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8594
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8589
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8567
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8561
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8549
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 4 0.8485
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8483
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8481
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8478
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8450
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8449
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8445
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8431
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8423
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8417
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8382
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8382
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8381
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8370
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8356
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8346
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8332
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8331
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8323
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8320
Beta-elicitin cinnamomin P15569 ELIB_PHYCI Phytophthora cinnamomi 4 0.8305
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8291
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.8272
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8255
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8254
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8238
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8238
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8237
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8216
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8186
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8114
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8070
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8066
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8065
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8059
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8058
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 4 0.8055
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7985
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7975
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7968
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7967
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7964
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7940
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7892
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7884
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7883
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7844
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7844
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7841
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7833
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7828
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7823
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7817
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7806
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7802
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7799
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7796
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7788
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7787
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7759
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7758
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7744
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7733
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7733
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7733
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7733
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7729
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7716
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7710
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7709
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7703
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7700
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7691
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7687
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7668
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7654
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7634
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7624
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7622
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7621
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7616
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7610
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7604
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7599
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7594
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7594
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7583
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7579
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7575
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.7567
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7565
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7556
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7552
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7548
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7541
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7540
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 4 0.7536
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 4 0.7535
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7533
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7532
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7532
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7532
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7522
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.7518
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7516
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7515
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7511
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7509
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7500
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7483
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7476
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7473
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7471
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7469
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7465
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7463
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7458
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7454
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7452
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7442
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7435
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7428
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.7428
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 3 0.7428
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7422
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7422
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7421
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7412
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7411
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.7410
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7408
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7402
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7391
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7382
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7376
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7371
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7355
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7354
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7329
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7327
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7319
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7317
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7315
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7314
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7310
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7308
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7298
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7294
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7293
Aclacinomycin 10-hydroxylase RdmB Q54527 RDMB_STREF Streptomyces purpurascens 3 0.7290
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7282
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7281
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7280
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 4 0.7268
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7260
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7250
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7250
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7249
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7245
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7239
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7238
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7233
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7233
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7231
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7224
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7219
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7215
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 5 0.7213
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 4 0.7209
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7209
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7201
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7189
Reductase homolog Q9ZGC1 Q9ZGC1_STRCY Streptomyces cyanogenus 3 0.7184
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7170
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7168
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7165
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7160
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7159
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7154
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7154
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7150
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7148
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7148
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7146
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7132
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7125
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7124
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7121
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7119
Sulfotransferase 1E1 P49891 ST1E1_MOUSE Mus musculus 4 0.7117
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7112
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7101
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.7100
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7099
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7094
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7093
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7091
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7090
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7085
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7082
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7080
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7075
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7073
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7070
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7066
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7064
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7058
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7048
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7043
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7031
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7017
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7016
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7015
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7014
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7011
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7003
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7002

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