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(Z)-3-(7-hydroxy-5-methoxyphenyl)-2-(6'-hydroxy-4'-methoxyphenyl)acrylaldehyde

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Stilbene
- Subclass: Formylated Stilbene

Canonical Smiles	O=C/C(=C/c1ccc(cc1OC)O)/c1ccc(cc1O)OC
InChI	InChI=1S/C17H16O5/c1-21-14-5-6-15(16(20)9-14)12(10-18)7-11-3-4-13(19)8-17(11)22-2/h3-10,19-20H,1-2H3/b12-7-
InChIKey	QETFXXXVFOYOIP-GHXNOFRVSA-N
Formula	C₁₇H₁₆O₅
HBA	5
HBD	2
MW	300.31
Rotatable Bonds	5
TPSA	75.99
LogP	2.85
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	22
Formal Charge	0
Fraction CSP3	0.12
Exact Mass	300.1
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Erythrina addisoniae	Leguminosae/Fabaceae	Plantae	2590682

Showing of synonyms

Nguyen PH, Na M, et al. (2010). New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae.. Bioorganic & medicinal chemistry letters,2010, 20(22), 6430-6434. [View] [PubMed]

Pubchem: 50899657

Zinc: ZINC000064513032

Nmrshiftdb2: 70032660

Chembl: CHEMBL1271773

Bindingdb: 50483016

No compound-protein relationship available.

SMILES: c1ccccc1C=Cc2ccccc2

Level: 1

Mol. Weight: 300.31 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 300.31 g/mol

Antiviral

Absorption

Caco-2 (logPapp): -4.66
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.64
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.31

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.59
Plasma Protein Binding: 39.88
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.47
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.93
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.05
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 6.09
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: 4.45
Rat (Acute): 1.95
Rat (Chronic Oral): 2.37
Fathead Minnow: 4.92
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 420.99
Hydration Free Energy: -11.41
Log(D) at pH=7.4: 2.52
Log(P): 2.95
Log S: -4.26
Log(Vapor Pressure): -6.73
Melting Point: 131.06
pKa Acid: 7.62
pKa Basic: 2.91

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.9525
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9373
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.9293
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9225
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9205
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9121
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.9107
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9090
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.9082
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.9074
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9025
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.8993
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8986
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8977
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8956
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8929
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8830
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8816
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.8813
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8802
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8802
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8773
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8755
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8718
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8708
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8686
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8684
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8605
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8523
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8522
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.8521
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8496
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.8465
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8461
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8450
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8438
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8426
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8422
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8361
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8350
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.8340
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8299
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8293
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8280
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8238
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.8236
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8229
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	3	0.8219
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8202
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8178
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8158
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8152
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8147
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8125
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8111
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8099
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8034
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8030
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8022
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.8004
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7989
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7959
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7957
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7953
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7948
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7939
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7908
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7869
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7844
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7796
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7751
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7740
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.7737
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7731
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7719
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7696
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.7690
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7684
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7681
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7668
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7668
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7663
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.7659
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7644
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7604
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7592
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7584
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7577
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	3	0.7575
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7572
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7551
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7550
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7547
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7545
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7533
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7527
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7524
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7523
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7512
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8ZMF7	ISPF_SALTY	Salmonella typhimurium	3	0.7512
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7503
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7497
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	3	0.7497
Thymidylate synthase ThyA	P9WFR9	TYSY_MYCTU	Mycobacterium tuberculosis	3	0.7486
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7482
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7479
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7467
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7454
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7430
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7425
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7425
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7420
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.7401
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7398
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	4	0.7397
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7397
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7395
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	3	0.7394
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7389
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7382
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7377
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7376
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7368
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7361
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7358
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7357
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7352
CDP-alcohol phosphatidyltransferase AF-2299-like N-terminal domain-containing protein	O27985	O27985_ARCFU	Archaeoglobus fulgidus	4	0.7350
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7346
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7343
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7337
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	3	0.7335
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7331
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7330
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7328
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7319
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7311
Terminal oxygenase component of carbazole	Q84II6	Q84II6_JANS3	Janthinobacterium sp	3	0.7308
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7304
Methionine--tRNA ligase	P00959	SYM_ECOLI	Escherichia coli	3	0.7300
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.7296
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7285
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7284
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7281
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7281
Orotidine 5'-phosphate decarboxylase	Q5L0U0	PYRF_GEOKA	Geobacillus kaustophilus	3	0.7279
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7276
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7258
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7254
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7250
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7244
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7238
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7237
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	3	0.7233
Pyruvate oxidase	P37063	POXB_LACPL	Lactiplantibacillus plantarum	3	0.7221
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7216
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7215
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7213
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7210
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7209
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7205
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7203
Abscisic acid receptor PYL9	Q84MC7	PYL9_ARATH	Arabidopsis thaliana	3	0.7203
Cytidylate kinase	B1MB31	B1MB31_MYCA9	Mycobacteroides abscessus	4	0.7199
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7190
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7190
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7185
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7180
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7178
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7178
Pyruvate dehydrogenase [ubiquinone]	P07003	POXB_ECOLI	Escherichia coli	3	0.7167
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7162
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7150
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7145
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7140
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7137
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7133
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7130
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7129
Nuclear receptor subfamily 5 group A member 2	O00482	NR5A2_HUMAN	Homo sapiens	3	0.7124
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7123
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7117
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7115
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7114
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7110
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7107
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7105
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7102
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	P23970	MEND_BACSU	Bacillus subtilis	3	0.7100
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7090
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	3	0.7090
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7084
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7068
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7063
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7058
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7058
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q3JRA0	ISPF_BURP1	Burkholderia pseudomallei	4	0.7055
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7048
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	3	0.7036
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7032
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7032
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7031
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7023
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	Q02745	SIA4A_PIG	Sus scrofa	4	0.7019
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7016
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7011
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7009
Thymidylate synthase	P45352	TYSY_RAT	Rattus norvegicus	2	0.7006
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7005
Metallo-beta-lactamase type 2	P26918	BLAB_AERHY	Aeromonas hydrophila	2	0.7001

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