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Isowighteone

Family: Plantae - Moraceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavonoid

Canonical Smiles	CC(=CCc1cc(ccc1O)c1coc2c(c1=O)c(O)cc(c2)O)C
InChI	InChI=1S/C20H18O5/c1-11(2)3-4-13-7-12(5-6-16(13)22)15-10-25-18-9-14(21)8-17(23)19(18)20(15)24/h3,5-10,21-23H,4H2,1-2H3
InChIKey	SWDSVBNAMCDHTF-UHFFFAOYSA-N
Formula	C₂₀H₁₈O₅
HBA	5
HBD	3
MW	338.36
Rotatable Bonds	3
TPSA	90.9
LogP	4.09
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.15
Exact Mass	338.12
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ficus mucuso	Moraceae	Plantae	309328
2	Erythrina addisoniae	Leguminosae/Fabaceae	Plantae	2590682

Showing of synonyms

Bankeu JJ, Khayala R, et al. (2011). Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.. Journal of natural products,2011, 74(6), 1370-1378. [View] [PubMed]
Nguyen PH, Na M, et al. (2010). New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae.. Bioorganic & medicinal chemistry letters,2010, 20(22), 6430-6434. [View] [PubMed]

Pubchem: 5494866

Cas: 68436-47-5

Zinc: ZINC000014819484

Chebi: 69749

Nmrshiftdb2: 60025753

Metabolights: MTBLC69749

Chembl: CHEMBL464460

Bindingdb: 50349975

No compound-protein relationship available.

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 338.36 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 338.36 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 338.36 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.86
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.87
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -0.44

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.96
Plasma Protein Binding: 79.34
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 1.27
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.63
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.52
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.75
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Toxic
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: 2.62
Rat (Acute): 2.3
Rat (Chronic Oral): 2.73
Fathead Minnow: 4.98
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 478.88
Hydration Free Energy: -12.54
Log(D) at pH=7.4: 3.98
Log(P): 4.91
Log S: -5.38
Log(Vapor Pressure): -9.17
Melting Point: 232.63
pKa Acid: 6.88
pKa Basic: 7.15

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9527
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.9425
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9390
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9204
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9169
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.9134
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	5	0.9126
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9109
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.9098
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9092
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.9089
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.9076
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	4	0.8906
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8876
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8876
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8842
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8820
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	5	0.8788
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8777
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8773
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8770
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8742
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8741
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8738
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8721
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8705
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8694
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8668
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8643
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8641
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8624
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8623
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8619
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	4	0.8498
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8484
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8463
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8432
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8420
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8405
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8328
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8293
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8285
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8250
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.8246
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8244
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8202
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8142
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8079
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.8075
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8050
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.8049
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8020
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8000
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7981
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7961
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7936
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7884
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7884
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7880
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7879
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7877
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7849
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7841
Phosphodiesterase	Q53I60	Q53I60_TRYCR	Trypanosoma cruzi	3	0.7821
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7808
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7798
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7777
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	4	0.7765
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7762
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7744
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7706
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7672
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7641
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7624
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7620
Serine/threonine-protein kinase B-raf	P15056	BRAF_HUMAN	Homo sapiens	4	0.7619
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7611
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7596
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7579
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7570
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7570
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7568
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7567
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7534
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7528
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7518
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7507
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7507
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7488
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7484
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7478
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7473
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7472
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7470
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7469
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7460
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7459
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7452
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7451
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	2	0.7442
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7430
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	4	0.7415
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7406
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7401
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7397
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.7389
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7385
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7369
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7346
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7345
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7342
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7334
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7329
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7327
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7321
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7320
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7319
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7316
Serine/threonine-protein kinase Nek2	P51955	NEK2_HUMAN	Homo sapiens	4	0.7315
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7315
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7311
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7310
Serine/threonine-protein kinase Nek2	P51955	NEK2_HUMAN	Homo sapiens	4	0.7307
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7307
Serine/threonine-protein kinase Nek2	P51955	NEK2_HUMAN	Homo sapiens	3	0.7304
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7304
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	4	0.7299
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	3	0.7298
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7278
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7277
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7272
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7262
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7257
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7246
Serine/threonine-protein kinase Nek2	P51955	NEK2_HUMAN	Homo sapiens	4	0.7245
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7234
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7234
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7227
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7221
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7211
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7193
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7190
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	3	0.7190
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7182
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7168
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7162
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7147
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7120
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7115
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7112
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7110
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7109
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7106
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	2	0.7105
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7097
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7093
Methionine adenosyltransferase 2 subunit beta	Q9NZL9	MAT2B_HUMAN	Homo sapiens	4	0.7086
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7083
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7081
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7080
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7075
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7067
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7065
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7064
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7064
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7062
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7053
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7053
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7049
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7040
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7037
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	4	0.7035
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7033
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7033
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7030
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7026
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7018
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.7013
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7010
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7006
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7005
Maltokinase	A1TH50	MAK_MYCVP	Mycolicibacterium vanbaalenii	3	0.7002
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	3	0.7001

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