Griffonianone H - Compound Card

Griffonianone H

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Griffonianone H

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles Oc1ccc2c(c1)occ(c2=O)c1cc(O)c2c(c1)OCO2
InChI InChI=1S/C16H10O6/c17-9-1-2-10-13(5-9)20-6-11(15(10)19)8-3-12(18)16-14(4-8)21-7-22-16/h1-6,17-18H,7H2
InChIKey BWIIKTOZYRGJBS-UHFFFAOYSA-N
Formula C16H10O6
HBA 6
HBD 2
MW 298.25
Rotatable Bonds 1
TPSA 89.13
LogP 2.6
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 298.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Millettia griffoniana Leguminosae/Fabaceae Plantae 3090223

Showing of synonyms

  • Ngamga D, Yankep E, et al. (2005). Isoflavonoids from Seeds of Millettia griffoniana (Bail). Zeitschrift für Naturforschung B. 2005, 60(9), 973-977. [View]
Pubchem: 46926107
Nmrshiftdb2: 70015958

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)ccc(c2)-c(c3=O)coc(c34)cccc4

Level: 1

Mol. Weight: 298.25 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 298.25 g/mol

Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 298.25 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.71
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.750
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.03

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.200
Plasma Protein Binding
84.08
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.270
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.300
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.340
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.530
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.870
Rat (Acute)
2.160
Rat (Chronic Oral)
2.090
Fathead Minnow
4.730
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
463.020
Hydration Free Energy
-10.680
Log(D) at pH=7.4
2.360
Log(P)
3.2
Log S
-4.57
Log(Vapor Pressure)
-9.4
Melting Point
291.65
pKa Acid
7.96
pKa Basic
3.18
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9594
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9592
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9563
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9518
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.9480
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9475
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9467
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.9454
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9273
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9215
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9202
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9173
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9154
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9108
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9101
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.9074
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9065
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9058
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9025
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9021
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9011
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8996
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8960
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8959
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8943
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8937
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8915
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8903
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.8887
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8836
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8836
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8808
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8805
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8796
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8794
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8775
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8745
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8734
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8730
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 4 0.8729
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.8710
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8702
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8696
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8694
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8677
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8643
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8622
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8616
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8615
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8603
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8584
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8575
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8558
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 3 0.8549
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.8518
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8480
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8466
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8459
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 4 0.8443
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8418
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 4 0.8415
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8403
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8392
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8376
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8371
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8365
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8362
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8351
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8295
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8232
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8230
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8213
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8201
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8199
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8164
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8163
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8147
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8137
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8126
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8115
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8098
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8085
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8084
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8082
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8077
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8065
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8056
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8052
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8050
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8049
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8043
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8041
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8027
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8015
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7996
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7989
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7987
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7986
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7976
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7976
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7974
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7955
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7900
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7897
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7886
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7872
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7872
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7870
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7868
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7862
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7828
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7796
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7777
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7756
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7754
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7752
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7751
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7749
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7737
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7716
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7705
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7703
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7686
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7677
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7656
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7655
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7645
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7638
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7638
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7622
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7603
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7595
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7591
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7589
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7588
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7573
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7567
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7565
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7560
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7553
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7548
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7547
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7541
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7537
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7532
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7526
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7514
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7492
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7491
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7486
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7483
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7482
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7476
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7459
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7456
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7454
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7434
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7433
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7422
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7420
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7406
Protein UshA P07024 USHA_ECOLI Escherichia coli 3 0.7395
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7388
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7385
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7384
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7383
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7383
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7379
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7367
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7365
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7362
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7352
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7347
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7347
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7344
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7338
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7333
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7320
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7314
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7302
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7286
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7285
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7283
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7280
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7279
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7278
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7273
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7266
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7265
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7260
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7255
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7242
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7237
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7234
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7233
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7229
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7228
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7220
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7213
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7209
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7200
Neutrophil collagenase P22894 MMP8_HUMAN Homo sapiens 2 0.7198
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7188
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7188
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7179
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7172
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7168
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7161
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7158
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7156
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7156
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7156
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7155
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7148
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7146
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7144
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7138
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7135
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7126
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7126
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7125
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7120
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7113
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7112
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7112
DNA polymerase theta O75417 DPOLQ_HUMAN Homo sapiens 4 0.7107
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7100
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7098
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7093
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.7090
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7090
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7090
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7089
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7088
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7084
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7076
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7075
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7074
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7069
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7064
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7054
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7052
Rho family GTPase C4M4W4 C4M4W4_ENTHI Entamoeba histolytica 4 0.7051
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7049
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7041
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7040
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7039
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7039
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7035
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7023
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.7021
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7018
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7007
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7003
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7003
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7002

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