1,6-dihydroxyxanthone - Compound Card

1,6-dihydroxyxanthone

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1,6-dihydroxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Malvaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles Oc1ccc2c(c1)oc1c(c2=O)c(O)ccc1
InChI InChI=1S/C13H8O4/c14-7-4-5-8-11(6-7)17-10-3-1-2-9(15)12(10)13(8)16/h1-6,14-15H
InChIKey IUSXGFFUHTXSRD-UHFFFAOYSA-N
Formula C13H8O4
HBA 4
HBD 2
MW 228.2
Rotatable Bonds 0
TPSA 70.67
LogP 2.36
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 228.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Sida rhombifolia Malvaceae Plantae 108377

Showing of synonyms

  • Kamdoum BC, Simo I, et al. (2022). Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity.. Natural product research,2022, 36(20), 5311-5318. [View] [PubMed]
Pubchem: 5493674
Nmrshiftdb2: 60026867
CPRiL: 268774
Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 228.2 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.91
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.560
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.82

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.780
Plasma Protein Binding
73.66
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.690
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.150
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.070
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.620
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.520
Rat (Acute)
1.940
Rat (Chronic Oral)
2.620
Fathead Minnow
4.510
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
411.790
Hydration Free Energy
-12.070
Log(D) at pH=7.4
3.330
Log(P)
3.33
Log S
-3.88
Log(Vapor Pressure)
-8.47
Melting Point
268.87
pKa Acid
5.71
pKa Basic
8.01
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9522
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9337
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9309
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9273
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9256
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9250
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9238
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9191
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.9130
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9060
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9022
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8986
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8984
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8977
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8944
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8937
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8908
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8907
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8893
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8851
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8842
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8830
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8826
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.8803
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8791
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8791
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8763
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8758
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8735
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8726
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8715
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8700
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8694
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.8679
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8638
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8634
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8612
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8608
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8598
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8588
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8572
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8547
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8545
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.8534
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8525
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8510
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8501
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8489
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8461
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8446
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8385
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8354
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8350
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8344
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8323
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8313
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8282
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.8255
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8229
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 4 0.8227
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8200
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8169
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8169
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8167
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.8148
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8112
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8098
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8084
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8075
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8074
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.8071
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8063
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 4 0.8028
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7993
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7993
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7967
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7963
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7943
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7936
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7936
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7921
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7921
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7912
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7911
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7904
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7896
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7875
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7866
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7859
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7858
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7856
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7840
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7815
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7812
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7802
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7801
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7789
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7774
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7772
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7770
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7754
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7748
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7747
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7745
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7738
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7734
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7727
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7720
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7703
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7697
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7689
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7665
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7650
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7639
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7638
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7627
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7621
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7617
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7613
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7612
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7606
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7606
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7602
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7590
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7583
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7582
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7568
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7565
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7564
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7562
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7554
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7552
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7550
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7545
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7533
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7521
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7519
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7518
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7517
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7517
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7513
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7508
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7488
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7484
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7482
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7475
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7472
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 4 0.7468
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7465
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7463
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7459
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7458
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7458
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7457
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7437
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7433
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7431
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7430
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7424
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7415
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7409
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7397
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7393
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7390
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7389
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7385
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7382
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7381
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7378
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7372
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 4 0.7370
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7370
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7365
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7358
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7355
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7352
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7348
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7347
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7335
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7334
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7333
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7329
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7327
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7319
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7315
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7314
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7308
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7308
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7273
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7264
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7256
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7254
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7254
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7253
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 2 0.7251
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7250
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7247
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7239
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7239
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7237
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7229
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7224
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7219
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7215
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7215
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7213
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7210
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7206
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7204
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7196
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7192
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7190
Insulin receptor P06213 INSR_HUMAN Homo sapiens 4 0.7181
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7177
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7175
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7170
uroporphyrinogen-III C-methyltransferase Q5SKH6 Q5SKH6_THET8 Thermus thermophilus 4 0.7164
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7158
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7158
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7154
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7148
Envelope glycoprotein gp160 Q0ED31 Q0ED31_9HIV1 Human immunodeficiency virus 1 3 0.7145
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7144
Dihydroorotate dehydrogenase (quinone), mitochondrial Q02127 PYRD_HUMAN Homo sapiens 3 0.7134
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7134
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7130
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7127
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7122
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7120
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7119
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7116
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7115
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7112
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7110
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7107
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7101
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7101
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 4 0.7097
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7097
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7085
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7083
Cytochrome P450 I6YD01 I6YD01_MYCTU Mycobacterium tuberculosis 4 0.7073
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7072
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7069
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7068
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7068
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7061
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7059
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7057
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7052
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7052
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7051
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7050
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7045
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7044
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7019
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7015
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7010
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7003

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