3,6,8-trihydroxy-2-(3,4-dihydroxylphenyl)-4H-chrom-4-one - Compound Card

3,6,8-trihydroxy-2-(3,4-dihydroxylphenyl)-4H-chrom-4-one

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3,6,8-trihydroxy-2-(3,4-dihydroxylphenyl)-4H-chrom-4-one

Structure
Zoomed Structure
  • Family: Plantae - Meliaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles Oc1cc(O)c2c(c1)c(=O)c(c(o2)c1ccc(c(c1)O)O)O
InChI InChI=1S/C15H10O7/c16-7-4-8-12(20)13(21)14(22-15(8)11(19)5-7)6-1-2-9(17)10(18)3-6/h1-5,16-19,21H
InChIKey OIMBRICSFUPIHX-UHFFFAOYSA-N
Formula C15H10O7
HBA 7
HBD 5
MW 302.24
Rotatable Bonds 1
TPSA 131.36
LogP 1.99
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 302.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pseudocedrela kotschyi Meliaceae Plantae 356281

Showing of synonyms

  • Sidjui LS, Nganso YOD, et al. (2018). Kostchyienones A and B, new antiplasmodial and cytotoxicity of limonoids from the roots of Pseudocedrela kotschyi (Schweinf.) Harms.. Zeitschrift fur Naturforschung. C, Journal of biosciences,2018, 73(3-4), 153-160. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 302.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 302.24 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 302.24 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-5.76
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.38
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.08

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.83
Plasma Protein Binding
98.92
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.55
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.14
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.06
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.9
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.33
Rat (Acute)
2.49
Rat (Chronic Oral)
3.6
Fathead Minnow
3.95
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
504.66
Hydration Free Energy
-10.85
Log(D) at pH=7.4
0.9
Log(P)
1.46
Log S
-2.94
Log(Vapor Pressure)
-7.97
Melting Point
332.25
pKa Acid
7.8
pKa Basic
6.89
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9481
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9226
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9151
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9147
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9083
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8980
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8963
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8943
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8939
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8809
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 5 0.8789
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8759
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8758
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8745
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8744
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8737
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8723
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8723
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8704
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8692
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8649
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8627
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8625
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8609
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8609
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8583
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8579
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 5 0.8576
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8568
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8564
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8547
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8519
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8513
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 5 0.8492
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8487
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8485
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8482
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8481
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8478
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8471
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8471
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8470
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8468
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8429
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8416
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8406
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8396
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8388
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8375
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8372
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8361
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8348
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8316
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8301
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8299
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8272
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 5 0.8264
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8242
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8242
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8242
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8235
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8234
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8231
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.8223
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8223
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8189
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8184
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8119
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8107
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8094
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8078
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8055
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8053
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8044
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8032
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 4 0.7974
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7948
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7945
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7940
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7937
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7918
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7904
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7887
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7883
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7876
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7874
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7862
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7862
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7861
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7855
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7850
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7839
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7810
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7807
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 5 0.7797
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7793
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7790
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7775
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7765
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7748
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7745
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7742
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7741
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7731
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7728
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7697
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7690
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7685
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7676
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7659
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 5 0.7647
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7635
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7624
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7617
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7610
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7610
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7596
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7591
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7581
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7560
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7550
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7545
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7545
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7536
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7535
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7526
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7524
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7520
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7518
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7507
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7505
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7493
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7484
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7483
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7483
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7479
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7473
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7467
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7465
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7464
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7450
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7442
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7425
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7423
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7409
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7402
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7400
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7397
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7385
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7382
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7380
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7373
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7373
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7364
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7357
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7354
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7348
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7348
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7343
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7341
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7336
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7335
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7333
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7332
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7332
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7330
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7318
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7315
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.7311
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 4 0.7308
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7305
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7299
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7284
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7278
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7273
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7273
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7269
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7263
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7242
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7239
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7232
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7226
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7208
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.7207
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7187
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7186
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7186
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7185
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7180
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7175
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7173
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7164
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7157
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7139
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7137
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7134
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7133
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7123
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7111
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7104
Thymidine phosphorylase P07650 TYPH_ECOLI Escherichia coli 4 0.7103
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7098
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7087
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7087
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7087
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7076
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7071
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7063
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7062
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7058
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7052
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7048
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 5 0.7047
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7047
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7039
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7037
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7036
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7033
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7030
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7022
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7013
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7007
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7005

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