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Viboquercitol
- Family: Plantae - Menispermaceae
- Kingdom: Plantae
- Class: Glycoside
Canonical Smiles | O[C@@H]1C[C@@H](O)[C@H]([C@@H]([C@H]1O)O)O |
---|---|
InChI | InChI=1S/C6H12O5/c7-2-1-3(8)5(10)6(11)4(2)9/h2-11H,1H2/t2-,3-,4-,5+,6+/m1/s1 |
InChIKey | IMPKVMRTXBRHRB-TVIMKVIFSA-N |
Formula | C6H12O5 |
HBA | 5 |
HBD | 5 |
MW | 164.16 |
Rotatable Bonds | 0 |
TPSA | 101.15 |
LogP | -2.81 |
Number Rings | 1 |
Number Aromatic Rings | 0 |
Heavy Atom Count | 11 |
Formal Charge | 0 |
Fraction CSP3 | 1.0 |
Exact Mass | 164.07 |
Number of Lipinski Rule Violations | 0 |
# | Species | Family | Kingdom | NCBI Taxonomy ID |
---|---|---|---|---|
1 | Penianthus longifolius | Menispermaceae | Plantae | 461618 |
Showing of synonyms
Viboquercitol
L-chiro-Inositol, 1-deoxy-
488-76-6
Vibo-Quercitol
(-)-Viburnitol
(-)-vibo-Quercitol
Viburnitol
(1R,2S,4R,5R)-cyclohexane-1,2,3,4,5-pentol
CHEBI:37600
D-1-deoxy-myo-inositol
1-D-3-deoxy-myo-inositol
(1R,2R,4S,5R)-cyclohexane-1,2,3,4,5-pentol
1L-1,2,4/3,5-cyclohexanepentol
CHEMBL37104
SCHEMBL5151166
CHEMBL3351099
SCHEMBL17925160
DTXSID10331579
IMPKVMRTXBRHRB-RSVSWTKNSA-N
(-)-Viboquercitol
L-Viburnitol
Quercitol, (-)-vibo-
Viburnitol, (-)-
HY-N1092
AKOS040755970
FS-9928
MD10114
CS-0016380
Q0069
C08259
H40356
Q27104416
(1R,2R,3R,4S,5R)-cyclohexane-1,2,3,4,5-pentaol
(1R,2R,3R,4S,5R)-cyclohexane-1,2,3,4,5-pentol
CPRiL:
359287
SMILES: C1CCCCC1
Level: 0
Mol. Weight: 164.16 g/mol
Antimalarial
Absorption
- Caco-2 (logPapp)
- -5.15
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -2.4
- Human Oral Bioavailability 50%
- Non-Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -2.43
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 0.49
- Plasma Protein Binding
- 31.41
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Non-Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Non-Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 1.4
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- -1.34
- Biodegradation
- Toxic
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Toxic
- Eye Corrosion
- Safe
- Eye Irritation
- Safe
- Maximum Tolerated Dose
- 2.51
- Liver Injury II
- Safe
- hERG Blockers
- Safe
- Daphnia Maga
- 2.47
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- -3.03
- Rat (Acute)
- 0.96
- Rat (Chronic Oral)
- 2.77
- Fathead Minnow
- 0.79
- Respiratory Disease
- Safe
- Skin Sensitisation
- Toxic
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 395.15
- Hydration Free Energy
- -23.16
- Log(D) at pH=7.4
- -2.34
- Log(P)
- -2.83
- Log S
- -0.14
- Log(Vapor Pressure)
- -10.59
- Melting Point
- 163.86
- pKa Acid
- 9.01
- pKa Basic
- 3.46
Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
---|---|---|---|---|---|
Trichothecene 15-O-acetyltransferase TRI3 | Q9C1B7 | TRI3_FUSSP | Fusarium sporotrichioides | 3 | 0.8515 |
Serpin domain-containing protein | H0ZQY2 | H0ZQY2_TAEGU | Taeniopygia guttata | 3 | 0.8348 |
2-aminohexano-6-lactam racemase | Q7M181 | ACLR_ACHOB | Achromobacter obae | 3 | 0.8218 |
Macrophage metalloelastase | P39900 | MMP12_HUMAN | Homo sapiens | 3 | 0.8004 |
Lysosomal acid glucosylceramidase | P04062 | GLCM_HUMAN | Homo sapiens | 3 | 0.7711 |
Glucosidase II subunit alpha | Q9STC1 | Q9STC1_GRALE | Gracilariopsis lemaneiformis | 3 | 0.7463 |