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(+)-fustin

Family: Plantae - Mimosoideae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavonol

Canonical Smiles	Oc1ccc2c(c1)O[C@@H]([C@H](C2=O)O)c1ccc(c(c1)O)O
InChI	InChI=1S/C15H12O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,14-18,20H/t14-,15+/m0/s1
InChIKey	FNUPUYFWZXZMIE-LSDHHAIUSA-N
Formula	C₁₅H₁₂O₆
HBA	6
HBD	4
MW	288.25
Rotatable Bonds	1
TPSA	107.22
LogP	1.48
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.13
Exact Mass	288.06
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Albizia glaberrima	Mimosoideae	Plantae	1179216

Showing of synonyms

Fotso GW, Kamga J, et al. (2017). Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae).. Natural product research,2017, 31(17), 1981-1987. [View] [PubMed]

Pubchem: 5317435

Cas: 20725-03-5

Gnps: CCMSLIB00005750503

Zinc: ZINC000001689527

Kegg Ligand: C01378

Nmrshiftdb2: 60065990

Metabolights: MTBLC228234

Chembl: CHEMBL470267

CPRiL: 212948

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 288.25 g/mol

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 288.25 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 288.25 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.11
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.030
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.2

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.860
Plasma Protein Binding: 82.07
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.250
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.180
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.420
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 4.130
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.570
Rat (Acute): 2.280
Rat (Chronic Oral): 2.930
Fathead Minnow: 4.050
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 445.200
Hydration Free Energy: -11.820
Log(D) at pH=7.4: 1.630
Log(P): 1.1
Log S: -2.69
Log(Vapor Pressure): -8.31
Melting Point: 253.08
pKa Acid: 5.8
pKa Basic: 5.35

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9790
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.9354
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9337
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9333
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9257
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9247
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9234
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.9215
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9214
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9213
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9198
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.9162
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.9158
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9145
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9144
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.9133
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.9084
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9035
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9018
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8950
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8938
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8926
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8924
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8876
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8838
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8834
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8820
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8787
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8776
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8759
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8744
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8741
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8729
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8725
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8717
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.8716
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8701
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8695
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8692
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	5	0.8680
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8625
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	5	0.8595
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8575
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8511
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8501
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8485
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8473
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8441
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.8438
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8437
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8418
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8400
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8399
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	7	0.8357
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.8348
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8342
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8309
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8302
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8254
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8243
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8236
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8216
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8205
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8195
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8194
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.8192
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8166
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8133
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8132
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8113
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8086
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8079
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8057
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8057
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.8049
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8024
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8005
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7998
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	6	0.7995
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7975
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7963
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	4	0.7942
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7930
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7921
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7910
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	5	0.7899
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.7897
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7877
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7868
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7866
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.7858
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7854
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7853
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7849
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7842
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7829
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7821
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7785
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7783
Quercetin 2,3-dioxygenase	Q7SIC2	QDOI_ASPJA	Aspergillus japonicus	4	0.7782
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7779
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7764
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7756
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7754
Rifampin ADP-ribosyl transferase	A0QRS5	A0QRS5_MYCS2	Mycolicibacterium smegmatis155)	4	0.7746
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7737
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7725
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7720
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7674
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7665
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7625
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7610
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7596
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7566
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7562
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7562
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7556
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7553
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7546
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7535
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7531
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7530
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7527
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7523
Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	PAR10_HUMAN	Homo sapiens	3	0.7521
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7505
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7490
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7469
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7467
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7454
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7446
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7438
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7430
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7425
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7417
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.7415
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7408
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7392
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7359
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7346
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7346
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7339
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7329
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7328
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7327
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7323
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7318
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7313
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7303
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.7296
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7292
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7290
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7284
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7280
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7275
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7264
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7261
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7256
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7253
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7248
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7207
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.7180
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7176
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7162
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7129
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.7124
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7123
Cytochrome P450 2C8	P10632	CP2C8_HUMAN	Homo sapiens	3	0.7120
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7118
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7107
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7092
Ascorbate-specific PTS system EIIC component	P39301	ULAA_ECOLI	Escherichia coli	3	0.7091
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.7061
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7060
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	4	0.7051
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7051
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7049
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7049
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7045
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7043
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7040
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7037
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7031
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	4	0.7026
Transitional endoplasmic reticulum ATPase	P55072	TERA_HUMAN	Homo sapiens	3	0.7014
Protein polybromo-1	Q86U86	PB1_HUMAN	Homo sapiens	4	0.7013
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7010
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7009
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7007

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