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Garbanzol

Family: Plantae - Moraceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavonol

Canonical Smiles	Oc1ccc(cc1)[C@H]1Oc2cc(O)ccc2C(=O)[C@@H]1O
InChI	InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)15-14(19)13(18)11-6-5-10(17)7-12(11)20-15/h1-7,14-17,19H/t14-,15+/m0/s1
InChIKey	VRTGGIJPIYOHGT-LSDHHAIUSA-N
Formula	C₁₅H₁₂O₅
HBA	5
HBD	3
MW	272.26
Rotatable Bonds	1
TPSA	86.99
LogP	1.78
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	20
Formal Charge	0
Fraction CSP3	0.13
Exact Mass	272.07
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ficus thonningii	Moraceae	Plantae	309310

Showing of synonyms

Ango PY, Kapche DW, et al. (2016). Thonningiiflavanonol A and thonningiiflavanonol B, two novel flavonoids, and other constituents of Ficus thonningii Blume (Moraceae).. Zeitschrift fur Naturforschung. C, Journal of biosciences,2016, 71(3-4), 65-71. [View] [PubMed]

Pubchem: 442410

Cas: 1226-22-8

Zinc: ZINC000004098319

Kegg Ligand: C09751

Chebi: 27587

Nmrshiftdb2: 60031683

Metabolights: MTBLC27587

Chembl: CHEMBL254051

Comptox: DTXSID40331820

No compound-protein relationship available.

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 272.26 g/mol

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 272.26 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 272.26 g/mol

Antioxidant

Absorption

Caco-2 (logPapp): -4.61
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.800
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.72

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.900
Plasma Protein Binding: 80.31
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.060
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.820
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.300
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.270
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Toxic
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.420
Rat (Acute): 2.170
Rat (Chronic Oral): 2.550
Fathead Minnow: 4.020
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 412.840
Hydration Free Energy: -11.390
Log(D) at pH=7.4: 1.900
Log(P): 1.48
Log S: -2.98
Log(Vapor Pressure): -7.96
Melting Point: 249.09
pKa Acid: 6.56
pKa Basic: 4.04

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9818
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9474
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9448
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.9444
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9440
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9431
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.9398
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9362
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9355
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9327
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9320
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9298
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.9296
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.9272
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9269
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.9262
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9241
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9214
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.9191
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.9172
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.9161
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9158
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.9115
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9107
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.9098
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.9092
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.9069
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.9064
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9059
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.9019
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.9008
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8997
Quercetin 2,3-dioxygenase	Q7SIC2	QDOI_ASPJA	Aspergillus japonicus	4	0.8989
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8975
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8959
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8942
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	5	0.8935
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8921
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8862
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8861
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8861
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8849
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8830
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.8826
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8818
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8721
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8716
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.8656
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8637
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	5	0.8626
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8611
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8588
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8586
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8577
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.8539
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8525
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	5	0.8520
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8493
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.8467
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8442
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8441
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8438
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8397
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.8387
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8344
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8343
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.8319
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8296
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8293
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	5	0.8258
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8257
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8238
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8231
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8230
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8228
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	4	0.8203
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8197
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.8196
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8175
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8146
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8130
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8129
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8117
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8116
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8098
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8068
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8063
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8063
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.8037
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8023
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7989
Ribosomal protein S6 kinase alpha-3	P18654	KS6A3_MOUSE	Mus musculus	5	0.7965
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7955
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7923
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7919
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7889
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7880
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7876
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7864
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7851
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7842
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7838
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.7834
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7830
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7817
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7812
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.7803
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7799
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.7781
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7772
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7761
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7748
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7728
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7718
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7709
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7702
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7700
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7668
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7666
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7662
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7653
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7622
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7621
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7605
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7605
Quercetin 2,3-dioxygenase	Q7SIC2	QDOI_ASPJA	Aspergillus japonicus	4	0.7598
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7596
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7594
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7591
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7563
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7557
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7549
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7533
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	4	0.7517
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7511
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7505
Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	PAR10_HUMAN	Homo sapiens	3	0.7494
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7482
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7460
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7459
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7448
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7435
Bifunctional dihydrofolate reductase-thymidylate synthase	Q07422	DRTS_TOXGO	Toxoplasma gondii	3	0.7433
Catalase-peroxidase	Q3JNW6	KATG_BURP1	Burkholderia pseudomallei	3	0.7425
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	6	0.7424
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7420
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7418
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7415
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7412
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7412
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7409
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7407
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7405
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7382
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7369
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7355
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.7341
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7340
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7324
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7323
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7322
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	4	0.7311
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7305
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7301
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7298
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7271
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.7262
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.7256
Protein polybromo-1	Q86U86	PB1_HUMAN	Homo sapiens	4	0.7252
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	4	0.7238
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7220
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7212
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7208
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7199
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7170
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7167
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.7163
Cytochrome P450 2C8	P10632	CP2C8_HUMAN	Homo sapiens	3	0.7158
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7157
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7155
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7155
Isoleucine--tRNA ligase	P56690	SYI_THET8	Thermus thermophilus	3	0.7151
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7149
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7144
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7143
Transitional endoplasmic reticulum ATPase	P55072	TERA_HUMAN	Homo sapiens	3	0.7142
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7133
Ascorbate-specific PTS system EIIC component	P39301	ULAA_ECOLI	Escherichia coli	3	0.7130
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7112
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7107
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7094
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7082
Dihydrofolate reductase type 1 from Tn4003	P13955	DYRA_STAAU	Staphylococcus aureus	4	0.7070
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7068
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7068
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7065
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.7056
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7056
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7053
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7050
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7050
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7045
23S rRNA (guanine(745)-N(1))-methyltransferase	P36999	RLMA_ECOLI	Escherichia coli	3	0.7041
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7040
Protein mono-ADP-ribosyltransferase PARP14	Q460N5	PAR14_HUMAN	Homo sapiens	3	0.7032
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7019
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.7018
RNA-directed RNA polymerase lambda-3	P0CK31	RDRP_REOVD	Reovirus type 3	3	0.7014
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7012
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7011
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7010

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