5,7,3′-trihydroxyflavanone - Compound Card

5,7,3′-trihydroxyflavanone

Select a section from the left sidebar

5,7,3′-trihydroxyflavanone

Structure
Zoomed Structure
  • Family: Plantae - Moraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles Oc1cccc(c1)C1CC(=O)c2c(O1)cc(cc2O)O
InChI InChI=1S/C15H12O5/c16-9-3-1-2-8(4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2
InChIKey NJWJQMLMBXIOJW-UHFFFAOYSA-N
Formula C15H12O5
HBA 5
HBD 3
MW 272.26
Rotatable Bonds 1
TPSA 86.99
LogP 2.51
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 272.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ficus thonningii Moraceae Plantae 309310

Showing of synonyms

  • Ango PY, Kapche DW, et al. (2016). Thonningiiflavanonol A and thonningiiflavanonol B, two novel flavonoids, and other constituents of Ficus thonningii Blume (Moraceae).. Zeitschrift fur Naturforschung. C, Journal of biosciences,2016, 71(3-4), 65-71. [View] [PubMed]
Pubchem: 113638
Chebi: 196259

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 272.26 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 272.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 272.26 g/mol

Antioxidant

Absorption

Caco-2 (logPapp)
-4.68
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.870
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.2

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.900
Plasma Protein Binding
60.12
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.480
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.920
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.270
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.490
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
4.170
Rat (Acute)
2.010
Rat (Chronic Oral)
2.730
Fathead Minnow
4.240
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
423.170
Hydration Free Energy
-11.820
Log(D) at pH=7.4
2.520
Log(P)
2.63
Log S
-3.87
Log(Vapor Pressure)
-7.88
Melting Point
215.07
pKa Acid
6.55
pKa Basic
6.83
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9763
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9602
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.9349
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9309
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9300
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9261
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9255
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9241
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9235
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9180
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9128
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9113
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9095
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9076
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9074
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9051
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9049
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9043
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9037
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9034
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8983
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8967
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8936
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8910
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8884
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8848
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8840
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8813
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8807
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8799
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8797
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8793
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8787
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8777
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8748
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8725
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8704
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8687
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8664
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8634
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8587
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8585
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8568
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8556
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8549
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.8517
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8515
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8515
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8469
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8466
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8465
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8425
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8421
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8387
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8377
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8376
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8365
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8360
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8339
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8332
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8326
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8322
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8312
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8288
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8230
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8163
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8145
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8115
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8112
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8107
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8106
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8101
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8092
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8083
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8065
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8059
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8037
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.8034
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8025
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8010
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.8008
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7977
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7976
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7963
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7958
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7957
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7956
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7934
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7933
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7928
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7928
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7926
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7921
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7918
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7916
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7911
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7883
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7875
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7871
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7871
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7865
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7865
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7861
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7859
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7845
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7831
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7828
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7821
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7818
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7815
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7814
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7806
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7765
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7750
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7729
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7720
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7708
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7693
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7690
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7690
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7682
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7678
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7676
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7670
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7661
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7654
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7646
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7634
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7628
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7624
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7601
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7595
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7591
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7580
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7576
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7569
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7569
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7565
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7556
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7551
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7550
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7542
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7542
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7539
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7534
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7528
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7523
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7522
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7519
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7518
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7515
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7502
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7498
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7496
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7495
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7482
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7477
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7475
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7473
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7451
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7446
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7445
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7441
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7434
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7417
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7416
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7414
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 3 0.7414
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7406
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7394
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7391
Protein UshA P07024 USHA_ECOLI Escherichia coli 3 0.7390
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 4 0.7373
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7358
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7352
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7341
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7341
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7340
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7338
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7337
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7322
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7310
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7309
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7308
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7308
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7307
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7302
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7297
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7295
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7292
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7290
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7279
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7278
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7272
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7264
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7260
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7257
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7246
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7245
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7244
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7232
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7228
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7227
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7227
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7224
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7223
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7218
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7217
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7217
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7213
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7213
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7212
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7212
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7211
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7211
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7208
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 3 0.7205
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7205
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7200
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7200
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7200
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7195
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7193
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7192
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7191
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7186
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7179
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7169
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7161
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7159
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7157
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7156
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7147
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7147
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7147
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7146
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7131
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7120
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7104
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7104
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7103
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7102
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7092
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7089
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7088
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7087
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7087
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7086
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7084
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7080
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7080
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7078
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7077
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7076
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7073
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7072
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7070
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7063
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7060
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7057
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7040
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7025
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7021
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7011

Download SDF