2-(3,5-dihydroxyphenyl)benzofuran-5,6-diol - Compound Card

2-(3,5-dihydroxyphenyl)benzofuran-5,6-diol

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2-(3,5-dihydroxyphenyl)benzofuran-5,6-diol

Structure
Zoomed Structure
  • Family: Plantae - Moraceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Benzofuran
Canonical Smiles Oc1cc(O)cc(c1)c1oc2c(c1)cc(c(c2)O)O
InChI InChI=1S/C14H10O5/c15-9-1-7(2-10(16)5-9)13-4-8-3-11(17)12(18)6-14(8)19-13/h1-6,15-18H
InChIKey FDARKUSEVNCTHK-UHFFFAOYSA-N
Formula C14H10O5
HBA 5
HBD 4
MW 258.23
Rotatable Bonds 1
TPSA 94.06
LogP 2.92
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 258.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Milicia excelsa Moraceae Plantae 58664
2 Morus mesozygia Moraceae Plantae 3054370

Showing of synonyms

  • Ouete JL, Sandjo LP, et al. (2014). Excelsoside: a new benzylic diglycoside from the leaves of Milicia excelsa.. Zeitschrift fur Naturforschung. C, Journal of biosciences,2014, 69(7-8), 271-275. [View] [PubMed]
  • Kapche GD, Amadou D, et al. (2011). Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia.. Planta medica,2011, 77(10), 1044-1047. [View] [PubMed]
Pubchem: 90703276
Nmrshiftdb2: 60024557
Bindingdb: 50083072

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(c2)-c3ccccc3

Level: 1

Mol. Weight: 258.23 g/mol

Structure

SMILES: c1coc(c12)cccc2

Level: 0

Mol. Weight: 258.23 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 258.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.14
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.88
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.99

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.72
Plasma Protein Binding
75.6
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.32
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.27
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.08
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.12
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.02
Rat (Acute)
1.83
Rat (Chronic Oral)
3.03
Fathead Minnow
4.46
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
448.43
Hydration Free Energy
-12.72
Log(D) at pH=7.4
2.46
Log(P)
2.22
Log S
-3.21
Log(Vapor Pressure)
-9.32
Melting Point
324.33
pKa Acid
7.65
pKa Basic
7.93
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9429
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9369
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9355
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9311
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9284
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9237
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9093
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9058
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.9020
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9009
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 4 0.8992
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8947
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8945
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8874
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8873
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8870
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8853
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8817
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8765
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8757
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8746
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8733
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8731
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8708
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8700
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8697
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8693
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8688
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8680
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8654
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8624
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8619
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8600
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8591
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8580
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8571
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8569
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8504
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8503
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8503
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8497
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8494
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8475
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8467
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8450
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8431
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8405
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8402
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8394
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8373
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8373
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8368
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8347
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8331
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8299
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8290
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8284
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8257
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8257
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.8232
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8229
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8210
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8209
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8189
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8178
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8178
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8173
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8145
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8136
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8125
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8112
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8106
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8093
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8089
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8086
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8086
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8074
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8062
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8060
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8055
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8052
Androgen receptor P19091 ANDR_MOUSE Mus musculus 4 0.8049
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8034
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8028
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8002
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8002
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7999
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7995
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7988
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7970
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7937
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7923
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7918
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7908
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7906
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7906
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7901
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7899
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7896
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7881
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7876
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7872
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7864
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7855
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7854
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7841
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7819
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7815
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7815
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7807
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7794
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7784
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7772
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7772
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7753
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7745
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7735
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7733
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7718
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7710
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7701
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7697
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7684
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7672
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7652
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7626
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7625
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7624
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7623
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7615
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7603
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7594
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7592
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7585
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7582
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7579
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7577
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7571
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7562
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7545
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7532
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7529
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7520
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7502
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7491
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7485
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7481
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.7479
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7452
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7431
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7428
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7412
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7404
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7399
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7387
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7376
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7374
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7368
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7367
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7353
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7343
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7325
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7324
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7324
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7317
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7317
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 4 0.7316
Avidin P02701 AVID_CHICK Gallus gallus 4 0.7315
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7315
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7307
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7305
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7303
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7302
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7298
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7290
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7278
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7277
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7275
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7272
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7269
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7267
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7265
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7265
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.7255
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7252
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7249
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7244
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7241
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7239
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7232
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7204
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7200
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7186
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7167
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7158
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7154
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7147
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7131
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7123
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7123
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7122
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7119
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7116
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7115
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7109
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7108
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 4 0.7093
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7090
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7083
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7082
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7056
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7053
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7051
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7050
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7047
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7040
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7039
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7037
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7034
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7029
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7019
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7014
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7005
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7003
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7002

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