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Moracin M

Family: Plantae - Moraceae
Kingdom: Plantae
Class: Phenolic
- Subclass: Benzofuran

Canonical Smiles	Oc1cc(O)cc(c1)c1oc2c(c1)ccc(c2)O
InChI	InChI=1S/C14H10O4/c15-10-2-1-8-5-13(18-14(8)7-10)9-3-11(16)6-12(17)4-9/h1-7,15-17H
InChIKey	LHPRYOJTASOZGJ-UHFFFAOYSA-N
Formula	C₁₄H₁₀O₄
HBA	4
HBD	3
MW	242.23
Rotatable Bonds	1
TPSA	73.83
LogP	3.22
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	18
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	242.06
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Morus mesozygia	Moraceae	Plantae	3054370
2	Morus mesozygia	Moraceae	Plantae	3054370
3	Morus mesozygia	Moraceae	Plantae	3054370

Showing of synonyms

Kapche GD, Amadou D, et al. (2011). Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia.. Planta medica,2011, 77(10), 1044-1047. [View] [PubMed]
Fozing CD, Ali Z, et al. (2012). Phosphodiesterase I-inhibiting Diels-Alder adducts from the leaves of Morus mesozygia.. Planta medica,2012, 78(2), 154-159. [View] [PubMed]
Fozing CDA (2009). Prenylated arylbenzofuran derivatives from Morus mesozygia with antioxidant activity.. Phytochemistry,2009, 70(2), 216-221. [View] [PubMed]

Pubchem: 185848

Cas: 56317-21-6

Zinc: ZINC000006092566

Chebi: 174251

Nmrshiftdb2: 10025018

Chembl: CHEMBL512578

Comptox: DTXSID20204861

Bindingdb: 50250915

CPRiL: 140084

SMILES: c1cccc(c12)oc(c2)-c3ccccc3

Level: 1

Mol. Weight: 242.23 g/mol

SMILES: c1coc(c12)cccc2

Level: 0

Mol. Weight: 242.23 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 242.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.91
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.69
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.16

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.79
Plasma Protein Binding: 68.81
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.25
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.57
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.13
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.21
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Toxic
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.93
Rat (Acute): 1.46
Rat (Chronic Oral): 2.64
Fathead Minnow: 4.54
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 422.03
Hydration Free Energy: -11.88
Log(D) at pH=7.4: 3.04
Log(P): 2.69
Log S: -3.6
Log(Vapor Pressure): -8.74
Melting Point: 294.43
pKa Acid: 8.09
pKa Basic: 7.51

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9693
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.9471
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9464
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9353
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9327
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9313
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9296
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9287
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.9256
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.9078
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.9065
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.9051
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.9022
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8944
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.8933
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8904
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.8892
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.8886
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.8860
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8855
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8853
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.8845
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8833
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8825
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8810
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8749
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8733
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8709
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.8707
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8707
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8653
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.8624
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	3	0.8612
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.8610
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8608
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	3	0.8593
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8571
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.8565
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8555
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8555
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8546
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8537
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8525
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8510
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8509
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8451
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.8448
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8443
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.8429
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8416
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8391
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8380
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8350
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8327
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8322
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.8315
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.8301
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8299
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.8293
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8288
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.8283
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.8280
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.8276
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8253
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8247
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8233
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	3	0.8229
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8227
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.8210
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8173
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8163
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8149
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8135
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8129
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.8122
Avidin	P02701	AVID_CHICK	Gallus gallus	4	0.8115
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8109
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8102
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8100
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8055
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7990
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7985
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7973
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7959
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	4	0.7935
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7918
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7897
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7896
NPC intracellular cholesterol transporter 1	O15118	NPC1_HUMAN	Homo sapiens	3	0.7893
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7888
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7882
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7880
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7872
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7825
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7811
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7806
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	3	0.7787
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7765
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7746
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7740
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.7737
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7734
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7720
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7716
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7713
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7709
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7701
Bifunctional adenosylcobalamin biosynthesis protein CobU	Q05599	COBU_SALTY	Salmonella typhimurium	4	0.7699
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7697
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7696
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7696
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7694
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7694
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7689
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7682
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Q15750	TAB1_HUMAN	Homo sapiens	3	0.7677
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	4	0.7675
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7663
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7662
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7648
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	3	0.7634
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7632
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7626
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7619
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	4	0.7596
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7594
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7592
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	4	0.7591
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	3	0.7570
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7565
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7563
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7550
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7547
Ephrin type-A receptor 2	P29317	EPHA2_HUMAN	Homo sapiens	3	0.7541
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7532
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7525
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7524
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7513
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7506
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7496
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	3	0.7496
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	Q6NVY1	HIBCH_HUMAN	Homo sapiens	3	0.7496
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	4	0.7486
Androgen receptor	P19091	ANDR_MOUSE	Mus musculus	3	0.7483
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7474
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7464
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7455
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7454
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7445
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7425
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7421
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7420
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7410
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7410
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7408
Sulfotransferase 1E1	P49888	ST1E1_HUMAN	Homo sapiens	3	0.7400
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7397
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	4	0.7392
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7392
Vitamin D3 receptor A	Q9PTN2	VDRA_DANRE	Danio rerio	4	0.7390
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7388
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7386
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7380
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7380
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7375
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7363
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7358
Cytochrome P450 2B4	P00178	CP2B4_RABIT	Oryctolagus cuniculus	3	0.7349
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7333
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7329
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7326
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7321
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7321
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7313
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7303
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7295
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7295
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7295
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7294
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7289
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7287
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7282
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7282
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7276
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	4	0.7275
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7269
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.7268
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7265
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7265
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7252
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7247
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	4	0.7245
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7223
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7222
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7216
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7215
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7208
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7204
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7202
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7200
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7192
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7171
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7170
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7169
Protein polybromo-1	Q86U86	PB1_HUMAN	Homo sapiens	4	0.7168
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.7165
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7164
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7158
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7157
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7151
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7146
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7142
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7140
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7139
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7139
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7139
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7138
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7118
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	2	0.7105
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7102
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7101
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7099
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7098
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7084
Kinesin heavy chain	Q41460	Q41460_SOLTU	Solanum tuberosum	3	0.7071
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7067
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	4	0.7062
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7051
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7048
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7046
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7046
Cyclin-dependent kinase 5	Q00535	CDK5_HUMAN	Homo sapiens	3	0.7045
Oxygenase	Q194P4	Q194P4_STRAA	Streptomyces argillaceus	3	0.7044
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7041
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7040
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7038
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7038
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7035
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7034
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7031
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7030
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7017
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7017
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7014
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	4	0.7013
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7011
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7010
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7009
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7007
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7005
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7004

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