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Moracin I

Family: Plantae - Moraceae
Kingdom: Plantae
Class: Phenolic
- Subclass: Benzofuran

Canonical Smiles	COc1cc(O)cc(c1CC=C(C)C)c1cc2c(o1)cc(cc2)O
InChI	InChI=1S/C20H20O4/c1-12(2)4-7-16-17(9-15(22)11-19(16)23-3)20-8-13-5-6-14(21)10-18(13)24-20/h4-6,8-11,21-22H,7H2,1-3H3
InChIKey	MRJQFSZVXAESPR-UHFFFAOYSA-N
Formula	C₂₀H₂₀O₄
HBA	4
HBD	2
MW	324.38
Rotatable Bonds	4
TPSA	62.83
LogP	5.03
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	24
Formal Charge	0
Fraction CSP3	0.2
Exact Mass	324.14
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Morus mesozygia	Moraceae	Plantae	3054370

Showing of synonyms

Kapche GD, Amadou D, et al. (2011). Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia.. Planta medica,2011, 77(10), 1044-1047. [View] [PubMed]

Pubchem: 155976

Cas: 73338-88-2

Zinc: ZINC000005158950

Nmrshiftdb2: 60062206

Chembl: CHEMBL463435

Comptox: DTXSID30223568

No compound-protein relationship available.

SMILES: c1cccc(c12)oc(c2)-c3ccccc3

Level: 1

Mol. Weight: 324.38 g/mol

SMILES: c1coc(c12)cccc2

Level: 0

Mol. Weight: 324.38 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 324.38 g/mol

Antioxidant

Hepatoprotective

Absorption

Caco-2 (logPapp): -4.91
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.690
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.08

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.140
Plasma Protein Binding: 72.99
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 3.600
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 2.260
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.820
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.440
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Toxic
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.360
Rat (Acute): 1.840
Rat (Chronic Oral): 2.760
Fathead Minnow: 5.290
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 422.430
Hydration Free Energy: -10.020
Log(D) at pH=7.4: 3.870
Log(P): 5.28
Log S: -5.94
Log(Vapor Pressure): -7.81
Melting Point: 186.54
pKa Acid: 9.37
pKa Basic: 6.97

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9406
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9378
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9336
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9264
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.9236
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.9084
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9037
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9013
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.9010
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.9007
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8974
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.8947
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.8937
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8903
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8886
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.8864
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.8825
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8818
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8774
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8738
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8704
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8694
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8689
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8672
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8672
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8668
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.8615
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.8611
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8600
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8589
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	3	0.8498
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8477
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8439
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.8415
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8393
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.8359
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8344
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8320
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.8275
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.8263
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8258
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8243
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8237
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.8167
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8166
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.8155
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8132
Phosphatidylinositol 3-kinase catalytic subunit type 3	Q8NEB9	PK3C3_HUMAN	Homo sapiens	4	0.8107
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.8097
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8082
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8078
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8062
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8049
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8025
Heat shock protein 75 kDa, mitochondrial	Q12931	TRAP1_HUMAN	Homo sapiens	4	0.8009
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7999
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7997
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7995
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7993
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.7975
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7960
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7940
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7925
Cytochrome P450 2B4	P00178	CP2B4_RABIT	Oryctolagus cuniculus	3	0.7881
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7879
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7860
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	2	0.7840
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7820
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7814
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.7813
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	4	0.7799
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7790
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	3	0.7787
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7755
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7711
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.7703
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7688
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7688
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7678
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7674
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7671
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7663
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7623
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7619
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	3	0.7612
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7579
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7576
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7574
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7573
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7560
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7559
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7556
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7546
Protein UshA	P07024	USHA_ECOLI	Escherichia coli	3	0.7516
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7511
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7496
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7480
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7477
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7475
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7470
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7465
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7462
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7459
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7456
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7450
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7447
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7445
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7441
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7437
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7422
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7415
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7406
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7404
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7400
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7372
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7361
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7353
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	3	0.7350
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7338
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7336
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7331
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7319
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7312
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7283
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	3	0.7283
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7279
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7274
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7273
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7266
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7258
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7258
Oxygenase	Q194P4	Q194P4_STRAA	Streptomyces argillaceus	3	0.7255
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7251
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.7249
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7244
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7241
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7241
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7230
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7229
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7224
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7214
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7210
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7207
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7201
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7198
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	2	0.7189
Cytochrome P450 2E1	P05181	CP2E1_HUMAN	Homo sapiens	3	0.7188
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7181
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7181
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7177
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7172
Mitogen-activated protein kinase kinase kinase 7	O43318	M3K7_HUMAN	Homo sapiens	3	0.7172
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7167
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7164
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7163
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7159
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	4	0.7156
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7155
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7155
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7152
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7145
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7137
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7136
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	3	0.7130
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7125
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7117
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7108
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7104
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7095
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7088
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7084
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7083
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7072
Putative N-acetyl glucosaminyl transferase	Q6U8B0	Q6U8B0_RAOTE	Raoultella terrigena	3	0.7072
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7070
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7070
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7066
Endochitinase B1	Q873X9	CHIB1_ASPFM	Aspergillus fumigatus	3	0.7064
Isoleucine--tRNA ligase	P56690	SYI_THET8	Thermus thermophilus	3	0.7061
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7061
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7060
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7050
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7044
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7041
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7033
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	3	0.7032
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7026
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7022
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7020
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7020
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7018
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7015
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7011
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	3	0.7010
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7009
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7007
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7004
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7002

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