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3-O-[6′-O-palmitoyl-beta-D-glucosyl]-spinasta-7,22(23)-diene
- Family: Plantae - Myrsinaceae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Triterpene Glycoside
Canonical Smiles | CCCCCCCCCCCCCCCCC(=O)OCC1OC(O[C@H]2CC[C@]3(C(C2)CC=C2C3CC[C@]3(C2CCC3[C@@H](/C=C/[C@H](C(C)C)CC)C)C)C)C(C(C1O)O)O |
---|---|
InChI | InChI=1S/C52H90O7/c1-8-10-11-12-13-14-15-16-17-18-19-20-21-22-23-46(53)57-35-45-47(54)48(55)49(56)50(59-45)58-40-30-32-51(6)39(34-40)26-27-41-43-29-28-42(52(43,7)33-31-44(41)51)37(5)24-25-38(9-2)36(3)4/h24-25,27,36-40,42-45,47-50,54-56H,8-23,26,28-35H2,1-7H3/b25-24+/t37-,38-,39?,40+,42?,43?,44?,45?,47?,48?,49?,50?,51+,52-/m1/s1 |
InChIKey | HCUWBRRJCRHCSO-NEUCVVNWSA-N |
Formula | C52H90O7 |
HBA | 7 |
HBD | 3 |
MW | 827.29 |
Rotatable Bonds | 24 |
TPSA | 105.45 |
LogP | 12.05 |
Number Rings | 5 |
Number Aromatic Rings | 0 |
Heavy Atom Count | 59 |
Formal Charge | 0 |
Fraction CSP3 | 0.9 |
Exact Mass | 826.67 |
Number of Lipinski Rule Violations | 2 |
# | Species | Family | Kingdom | NCBI Taxonomy ID |
---|---|---|---|---|
1 | Embelia rowlandii | Myrsinaceae | Plantae | 459628 |
Showing of synonyms
3-O-[6′-O-palmitoyl-beta-D-glucosyl]-spinasta-7,22(23)-diene
No compound-protein relationship available.
SMILES: C1CCC(C12)CCC3C2=CCC4C3CCC(C4)OC5CCCCO5
Level: 1
Mol. Weight: 827.29 g/mol
SMILES: C1CCC(C12)CCC3C2=CCC4C3CCCC4
Level: 0
Mol. Weight: 827.29 g/mol
SMILES: C1CCOCC1
Level: 0
Mol. Weight: 827.29 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -4.95
- Human Oral Bioavailability 20%
- Non-Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- 154.39
- Human Oral Bioavailability 50%
- Non-Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Substrate
- Skin Permeability
- 20857.89
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 1.92
- Plasma Protein Binding
- 83.08
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Non-Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Inhibitor
Excretion
- Clearance
- 2.43
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Toxic
- Bee
- Toxic
- Bioconcentration Factor
- -485.86
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Toxic
- Liver Injury I (DILI)
- Toxic
- Eye Corrosion
- Safe
- Eye Irritation
- Safe
- Maximum Tolerated Dose
- -0.53
- Liver Injury II
- Safe
- hERG Blockers
- Toxic
- Daphnia Maga
- 4.63
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- -37861235.77
- Rat (Acute)
- 2.61
- Rat (Chronic Oral)
- 3.32
- Fathead Minnow
- 47799.88
- Respiratory Disease
- Toxic
- Skin Sensitisation
- Toxic
- SR-ARE
- Toxic
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 4256320.34
- Hydration Free Energy
- -2.92
- Log(D) at pH=7.4
- 7.48
- Log(P)
- 15.14
- Log S
- -6.41
- Log(Vapor Pressure)
- -140049.78
- Melting Point
- 93.95
- pKa Acid
- -952.67
- pKa Basic
- 8.1
Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
---|---|---|---|---|---|
Xylose isomerase | P24300 | XYLA_STRRU | Streptomyces rubiginosus | 3 | 0.9164 |
Probable NDP-rhamnosyltransferase | Q9ALM8 | Q9ALM8_SACSN | Saccharopolyspora spinosa | 3 | 0.7302 |
Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.7018 |