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6,7-dimethoxy-3',4'-dimethoxyisoflavone

Family: Plantae - Ochnaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavone

Canonical Smiles	COc1ccc(cc1OC)c1coc2c(c1=O)cc(c(c2)OC)OC
InChI	InChI=1S/C19H18O6/c1-21-14-6-5-11(7-16(14)22-2)13-10-25-15-9-18(24-4)17(23-3)8-12(15)19(13)20/h5-10H,1-4H3
InChIKey	OYSKBZHHLYECLU-UHFFFAOYSA-N
Formula	C₁₉H₁₈O₆
HBA	6
HBD	0
MW	342.35
Rotatable Bonds	5
TPSA	67.13
LogP	3.49
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.21
Exact Mass	342.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ochna schweinfurthiana	Ochnaceae	Plantae	2699578

Showing of synonyms

Ndongo JT, Issa ME, et al. (2015). Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana.. Natural product research,2015, 29(17), 1684-1687. [View] [PubMed]

Pubchem: 631176

Cas: 24126-93-0

Zinc: ZINC000002553968

Nmrshiftdb2: 70014686

Chembl: CHEMBL234932

No compound-protein relationship available.

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 342.35 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 342.35 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 342.35 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp): -4.64
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.500
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.59

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.340
Plasma Protein Binding: 77.44
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.220
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 2.180
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.230
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.690
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 1.230
Rat (Acute): 2.570
Rat (Chronic Oral): 1.730
Fathead Minnow: 5.300
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 444.140
Hydration Free Energy: -8.030
Log(D) at pH=7.4: 2.410
Log(P): 2.66
Log S: -3.95
Log(Vapor Pressure): -6.85
Melting Point: 172.0
pKa Acid: 8.82
pKa Basic: 0.73

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9812
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9591
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9580
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9575
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9482
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9475
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9450
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9429
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.9400
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9372
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.9304
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9292
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9217
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9150
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9129
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9116
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9046
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9038
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9007
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.8929
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.8900
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8862
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.8808
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8806
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8763
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8757
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8740
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8740
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8715
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8685
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8681
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8653
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8631
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8611
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8589
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8558
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8556
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.8547
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8523
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.8503
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.8482
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8472
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8454
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8436
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8429
Cyclic nucleotide-binding domain-containing protein	E0RR11	E0RR11_SPITD	Spirochaeta thermophila	3	0.8342
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8315
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8291
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.8290
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8244
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8240
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.8165
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.8097
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8090
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.8047
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.8044
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.8042
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8034
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	4	0.8022
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8015
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7962
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7899
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7896
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7886
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7886
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7842
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7817
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7815
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7800
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7795
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7791
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7791
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7790
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7787
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7759
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7731
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7711
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.7706
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7656
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7637
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7619
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7610
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7606
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7605
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7604
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7597
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7595
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7587
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7571
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7565
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7546
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7542
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7541
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7539
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7534
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7523
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7519
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7517
Cyclic nucleotide-gated potassium channel mll3241	Q98GN8	CNGK1_RHILO	Mesorhizobium japonicum)	3	0.7509
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7504
Farnesyl pyrophosphate synthase	P14324	FPPS_HUMAN	Homo sapiens	2	0.7504
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7503
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7488
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7474
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7459
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7455
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7454
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7449
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7446
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7422
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7420
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	2	0.7405
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7402
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7402
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7385
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7381
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7378
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7367
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7349
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7347
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7326
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7315
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7312
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7298
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7296
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7293
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	3	0.7283
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7276
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7274
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7269
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7267
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7265
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7248
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7247
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7246
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7243
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7243
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7240
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7240
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7234
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7225
Phosphoenolpyruvate carboxykinase [GTP]	P9WIH3	PCKG_MYCTU	Mycobacterium tuberculosis	3	0.7221
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7218
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	2	0.7218
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7213
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7213
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7206
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7206
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7205
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7198
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7194
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7191
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7175
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7175
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7174
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7170
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7166
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7164
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7162
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7161
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	2	0.7159
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7158
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7157
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7152
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7145
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7144
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7138
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7137
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7129
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7129
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7126
Fatty acid-binding protein, adipocyte	P04117	FABP4_MOUSE	Mus musculus	2	0.7121
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7121
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7120
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7109
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7107
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7106
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7105
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7100
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7097
Nucleoside phosphorylase, putative	Q57VZ2	Q57VZ2_TRYB2	Trypanosoma brucei brucei	3	0.7096
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7090
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7089
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7085
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7083
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7082
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7080
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7078
Type IV pilus retractation ATPase PilT	P24559	PILT_PSEAE	Pseudomonas aeruginosa	3	0.7071
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7066
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7062
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7057
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7054
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7053
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7053
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7046
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7045
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7044
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7039
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7036
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7030
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7030
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7007
Interleukin-2	P60568	IL2_HUMAN	Homo sapiens	2	0.7005
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7001

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