(S)-(–)-onysilin - Compound Card

(S)-(–)-onysilin

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(S)-(–)-onysilin

Structure
Zoomed Structure
  • Family: Plantae - Polygonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COc1cc2O[C@@H](CC(=O)c2c(c1)OC)c1ccccc1
InChI InChI=1S/C17H16O4/c1-19-12-8-15(20-2)17-13(18)10-14(21-16(17)9-12)11-6-4-3-5-7-11/h3-9,14H,10H2,1-2H3/t14-/m0/s1
InChIKey IAFBOKYTDSDNHV-AWEZNQCLSA-N
Formula C17H16O4
HBA 4
HBD 0
MW 284.31
Rotatable Bonds 3
TPSA 44.76
LogP 3.41
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 284.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Polygonum limbatum Polygonaceae Plantae 488000

Showing of synonyms

  • Kuete V, Nkuete AH, et al. (2014). Cytotoxicity and modes of action of 4'-hydroxy-2',6'-dimethoxychalcone and other flavonoids toward drug-sensitive and multidrug-resistant cancer cell lines.. Phytomedicine : international journal of phytotherapy and phytopharmacology,2014, 21(12), 1651-1657. [View] [PubMed]
Pubchem: 689011
Nmrshiftdb2: 60146019

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 284.31 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 284.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 284.31 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.67
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.510
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.24

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.340
Plasma Protein Binding
82.02
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.530
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.720
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.540
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
6.360
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.470
Rat (Acute)
1.880
Rat (Chronic Oral)
1.970
Fathead Minnow
4.760
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
381.980
Hydration Free Energy
-8.290
Log(D) at pH=7.4
2.710
Log(P)
3.34
Log S
-4.48
Log(Vapor Pressure)
-6.05
Melting Point
106.91
pKa Acid
10.86
pKa Basic
3.02
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9863
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9825
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9600
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9553
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9509
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9494
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9494
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9467
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9445
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9367
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9338
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9291
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9286
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9242
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9156
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.9145
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9140
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9121
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9105
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9095
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9082
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8991
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8940
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8920
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8864
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8822
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8788
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8740
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8736
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8698
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8692
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8550
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8525
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8511
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8486
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8473
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8458
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8455
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8411
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8388
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8372
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8360
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8313
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8312
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8258
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8237
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8197
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8197
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8187
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8168
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8165
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8159
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8156
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8143
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8134
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8127
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.8116
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8109
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8107
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.8099
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8075
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8064
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8062
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8047
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8023
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.8011
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.8006
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7996
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7987
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7947
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7940
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7931
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7927
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7925
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7890
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7888
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7878
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7874
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7852
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7851
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7833
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7816
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7806
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7770
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7755
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7753
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7747
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7739
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7728
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7724
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7721
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7711
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7700
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7699
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 3 0.7695
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7694
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7649
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7648
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7645
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7644
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7643
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7643
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7630
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7612
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7603
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7602
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7577
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7574
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7572
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7571
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7566
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7537
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7535
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7531
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7502
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7494
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7492
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7491
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7473
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7473
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7463
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7461
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7451
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7449
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7446
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7445
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7426
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7411
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7404
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7403
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7398
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7387
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7370
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7369
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7362
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7358
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7357
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 4 0.7355
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7354
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7352
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7345
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7340
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7327
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7326
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 2 0.7320
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7310
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7308
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7297
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7296
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7282
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7280
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7278
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7269
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7266
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7265
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7262
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7261
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7242
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7241
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7226
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7225
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7223
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7221
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7220
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7211
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7211
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7202
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7201
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7201
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7199
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7193
Prostatic acid phosphatase P15309 PPAP_HUMAN Homo sapiens 2 0.7192
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7182
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7181
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7168
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7167
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7162
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7144
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7131
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7128
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7125
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7122
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7120
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7119
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7110
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7097
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7091
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7088
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7084
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7084
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7082
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7080
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7073
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7072
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 3 0.7069
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7058
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7042
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7039
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7037
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7036
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7035
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7026
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7024
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7023
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7005

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