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Excavatin D

Family: Plantae - Rutaceae
Kingdom: Plantae
Class: Coumarin

Canonical Smiles	O=c1ccc2c(o1)cc(cc2)OCC1OC1(C)CC1OC(=O)C(C1)(C)O
InChI	InChI=1S/C19H20O7/c1-18(22)8-13(24-17(18)21)9-19(2)15(26-19)10-23-12-5-3-11-4-6-16(20)25-14(11)7-12/h3-7,13,15,22H,8-10H2,1-2H3
InChIKey	UMYAEKVHXDURJS-UHFFFAOYSA-N
Formula	C₁₉H₂₀O₇
HBA	7
HBD	1
MW	360.36
Rotatable Bonds	5
TPSA	98.5
LogP	1.79
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	26
Formal Charge	0
Fraction CSP3	0.47
Exact Mass	360.12
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Clausena anisata	Rutaceae	Plantae	159034

Showing of synonyms

Tatsimo SJN, Tamokou JDD, et al. (2015). LC-MS guided isolation of antibacterial and cytotoxic constituents from Clausena anisata. Med Chem Res, 2015, 24, 1468–1479. [View]

Pubchem: 15871351

Cas: 250293-31-3

Gnps: CCMSLIB00006562873

Nmrshiftdb2: 80009962

Chembl: CHEMBL470442

No compound-protein relationship available.

SMILES: O=C1CCC(O1)CC2C(O2)COc(cc3)cc(c34)oc(=O)cc4

Level: 2

Mol. Weight: 360.36 g/mol

SMILES: O1CC1COc(cc2)cc(c23)oc(=O)cc3

Level: 1

Mol. Weight: 360.36 g/mol

SMILES: O1CC1CC(O2)CCC2=O

Level: 1

Mol. Weight: 360.36 g/mol

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 360.36 g/mol

SMILES: O=C1CCCO1

Level: 0

Mol. Weight: 360.36 g/mol

SMILES: C1CO1

Level: 0

Mol. Weight: 360.36 g/mol

Cancer cell growth inhibitory

Absorption

Caco-2 (logPapp): -4.97
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.790
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.71

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.620
Plasma Protein Binding: 5.96
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.720
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.530
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.770
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.590
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -1.820
Rat (Acute): 3.520
Rat (Chronic Oral): 1.200
Fathead Minnow: 4.660
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 440.010
Hydration Free Energy: -6.930
Log(D) at pH=7.4: 1.270
Log(P): 1.1
Log S: -3.25
Log(Vapor Pressure): -7.51
Melting Point: 132.79
pKa Acid: 5.6
pKa Basic: 4.51

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9731
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9729
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.9715
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9604
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9508
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	3	0.9465
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.9410
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9396
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.9337
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.9213
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.9187
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.9119
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.9064
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.9024
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.9002
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8990
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8977
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8969
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.8938
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8927
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8850
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8812
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8740
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8737
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.8540
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.8471
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.8420
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8387
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8349
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8329
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.8325
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8315
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8306
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8290
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.8272
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	3	0.8255
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.8160
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8159
Cytochrome P450 2E1	P05181	CP2E1_HUMAN	Homo sapiens	3	0.8158
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8157
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	4	0.8151
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8137
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8135
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	3	0.8121
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8066
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8043
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8041
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.8038
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.8031
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8002
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7954
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7916
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7890
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7852
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7851
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7847
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7838
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7814
N-alpha-acetyltransferase 50	Q9GZZ1	NAA50_HUMAN	Homo sapiens	3	0.7806
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7799
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7797
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7788
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7775
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7773
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7767
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.7756
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7750
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7741
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.7723
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7718
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7716
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7683
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7672
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7655
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7644
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7637
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7634
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	2	0.7631
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	2	0.7601
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7594
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7589
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7586
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7579
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7566
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7553
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	2	0.7551
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7551
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7548
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7547
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7545
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	2	0.7540
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.7532
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7531
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7501
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.7471
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7459
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7456
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7450
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	3	0.7445
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7429
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7405
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7384
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7381
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7379
Raucaffricine-O-beta-D-glucosidase	Q9SPP9	RG1_RAUSE	Rauvolfia serpentina	3	0.7376
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7375
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7373
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7367
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7367
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7366
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7365
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7365
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	4	0.7360
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7360
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7359
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7357
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7347
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7346
Dicamba O-demethylase, oxygenase component	Q5S3I3	DDMC_STEMA	Stenotrophomonas maltophilia	2	0.7322
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7315
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7302
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7302
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7289
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7279
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	2	0.7277
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7267
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7264
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7257
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7249
Sulfotransferase 1E1	P49888	ST1E1_HUMAN	Homo sapiens	3	0.7245
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7244
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7243
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	2	0.7241
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7230
Aldo-keto reductase family 1 member A1	P50578	AK1A1_PIG	Sus scrofa	3	0.7223
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7213
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7205
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7205
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7204
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7192
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7189
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7188
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7186
Ferrichrome outer membrane transporter/phage receptor	P06971	FHUA_ECOLI	Escherichia coli	3	0.7185
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7185
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7184
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7183
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	2	0.7177
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	2	0.7176
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7173
[LysW]-aminoadipate kinase	O50147	LYSZ_THET2	Thermus thermophilus	3	0.7167
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7161
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7160
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7155
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7149
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7147
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7138
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7133
Cytochrome P450 3A4	P08684	CP3A4_HUMAN	Homo sapiens	3	0.7128
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7126
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7126
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7125
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7125
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7125
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7123
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7117
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7104
Acetyl-CoA acetyltransferase	P14611	THIL_CUPNH	Cupriavidus necator	2	0.7102
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7101
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7098
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7088
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7088
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7087
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7086
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7084
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7074
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7069
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7046
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7038
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7036
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7033
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7028
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7025
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7020
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7004
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7003

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