7-[(E)-7-hydroxy-3,7-dimethylocta-2,5- dienyloxyl]-coumarin - Compound Card

7-[(E)-7-hydroxy-3,7-dimethylocta-2,5- dienyloxyl]-coumarin

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7-[(E)-7-hydroxy-3,7-dimethylocta-2,5- dienyloxyl]-coumarin

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Coumarin
Canonical Smiles C/C(=C\COc1ccc2c(c1)oc(=O)cc2)/CC=CC(O)(C)C
InChI InChI=1S/C19H22O4/c1-14(5-4-11-19(2,3)21)10-12-22-16-8-6-15-7-9-18(20)23-17(15)13-16/h4,6-11,13,21H,5,12H2,1-3H3/b11-4?,14-10+
InChIKey ZHQPRJMIAALFHX-AEXGACAHSA-N
Formula C19H22O4
HBA 4
HBD 1
MW 314.38
Rotatable Bonds 6
TPSA 59.67
LogP 3.84
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.32
Exact Mass 314.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Clausena anisata Rutaceae Plantae 159034

Showing of synonyms

  • Tatsimo SJN, Tamokou JDD, et al. (2015). LC-MS guided isolation of antibacterial and cytotoxic constituents from Clausena anisata. Med Chem Res, 2015, 24, 1468–1479. [View]
Pubchem: 129886826

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 314.38 g/mol

Antibacterial
Cancer cell growth inhibitory

Absorption

Caco-2 (logPapp)
-4.69
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.27
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.37

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.2
Plasma Protein Binding
60.37
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.6
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.73
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.41
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.14
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.27
Rat (Acute)
2.09
Rat (Chronic Oral)
1.79
Fathead Minnow
5.19
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
397.28
Hydration Free Energy
-10.05
Log(D) at pH=7.4
2.91
Log(P)
3.36
Log S
-4.96
Log(Vapor Pressure)
-6.59
Melting Point
116.67
pKa Acid
8.48
pKa Basic
6.95
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.9863
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9751
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9746
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9621
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9609
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9599
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9547
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9518
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9491
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9469
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.9243
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9174
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9157
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9078
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8944
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8866
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8862
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8857
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.8844
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8746
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8733
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8677
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8609
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8538
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8532
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8491
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8426
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8419
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.8395
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8390
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8366
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8319
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.8248
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8243
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8227
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8224
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 4 0.8207
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8201
Cytochrome b6 P83791 CYB6_MASLA Mastigocladus laminosus 3 0.8198
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8170
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8150
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8137
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8135
Fatty acid-binding protein, intestinal P02693 FABPI_RAT Rattus norvegicus 3 0.8134
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.8097
Retinol-binding protein 4 P02753 RET4_HUMAN Homo sapiens 4 0.8094
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8082
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.8063
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.8060
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8049
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8012
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7999
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7991
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7976
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7964
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7948
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7931
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7924
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7874
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7871
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7866
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7863
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7850
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7847
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7844
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7809
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7808
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7799
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7792
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7771
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7754
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7749
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7745
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7742
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7740
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.7740
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7737
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7730
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7725
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7722
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7722
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7695
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7692
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7678
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7677
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7667
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7658
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7658
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7647
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7646
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7643
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7642
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7637
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7627
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7622
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7611
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7598
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7597
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7592
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7582
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7581
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7577
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7567
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7565
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7561
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7559
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7552
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7547
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7539
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7534
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7532
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7531
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7530
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7527
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7519
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7516
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7513
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7512
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7512
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7503
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7501
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7501
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7494
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7493
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7492
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7487
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7480
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7477
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7470
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7467
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7466
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7459
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7458
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7456
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7449
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7446
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7443
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7439
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7435
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7428
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7428
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7421
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7411
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 4 0.7402
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7399
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7395
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7392
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7392
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7381
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7380
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7376
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7372
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7364
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7359
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7353
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7349
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7346
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7344
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.7340
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7339
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7332
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7327
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7315
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7314
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7308
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7306
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7297
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7292
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7287
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7281
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7278
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7271
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7268
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7267
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7266
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7262
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7258
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7257
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7254
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7248
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7246
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7245
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7243
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7223
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7223
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7220
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7213
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7211
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7208
Glycylpeptide N-tetradecanoyltransferase A5K1A2 A5K1A2_PLAVS Plasmodium vivax 3 0.7203
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7203
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7201
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7198
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7193
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7191
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7189
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7187
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7187
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7183
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7176
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7168
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7167
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7164
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7161
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7161
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7157
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7156
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7156
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7152
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7152
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7151
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7146
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7144
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7143
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7142
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7139
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7138
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7136
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7136
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7135
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7134
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7131
Alpha-tocopherol transfer protein Q8BWP5 TTPA_MOUSE Mus musculus 4 0.7127
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7126
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7122
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7120
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7119
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7118
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7116
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7114
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7113
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7110
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7101
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.7101
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7095
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7092
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7090
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7090
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7084
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7084
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7078
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7077
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7074
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7062
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7061
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7059
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7055
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7055
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7052
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7048
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7045
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7037
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7034
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7031
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7026
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7024
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7023
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7020
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7017
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.7016
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7010
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7009
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7005

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