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Excavatin D

Family: Plantae - Rutaceae
Kingdom: Plantae
Class: Coumarin

Canonical Smiles	C/C(=C\COc1ccc2c(c1)oc(=O)cc2)/C[C@@H]1OC(=O)C(=C1)C
InChI	InChI=1S/C19H18O5/c1-12(9-16-10-13(2)19(21)23-16)7-8-22-15-5-3-14-4-6-18(20)24-17(14)11-15/h3-7,10-11,16H,8-9H2,1-2H3/b12-7+/t16-/m0/s1
InChIKey	CFNMUZCFSDMZPQ-MZTACXPWSA-N
Formula	C₁₉H₁₈O₅
HBA	5
HBD	0
MW	326.35
Rotatable Bonds	5
TPSA	65.74
LogP	3.38
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	24
Formal Charge	0
Fraction CSP3	0.26
Exact Mass	326.12
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Clausena anisata	Rutaceae	Plantae	159034

Showing of synonyms

Tatsimo SJN, Tamokou JDD, et al. (2015). LC-MS guided isolation of antibacterial and cytotoxic constituents from Clausena anisata. Med Chem Res, 2015, 24, 1468–1479. [View]

Pubchem: 15485570

Cas: 30825-45-7

Zinc: ZINC000001583492

Nmrshiftdb2: 70131570

No compound-protein relationship available.

SMILES: O=C1C=CC(O1)CC=CCOc(cc2)cc(c23)oc(=O)cc3

Level: 1

Mol. Weight: 326.35 g/mol

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 326.35 g/mol

SMILES: O=C1C=CCO1

Level: 0

Mol. Weight: 326.35 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.72
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.76
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.5

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.19
Plasma Protein Binding: 66.47
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.75
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.96
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.35
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.06
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 0.33
Rat (Acute): 2.31
Rat (Chronic Oral): 1.48
Fathead Minnow: 5.1
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 432.42
Hydration Free Energy: -7.38
Log(D) at pH=7.4: 3.12
Log(P): 2.83
Log S: -4.98
Log(Vapor Pressure): -7.27
Melting Point: 145.09
pKa Acid: 7.8
pKa Basic: 6.23

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.9852
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9744
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9715
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9666
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.9640
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9562
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9501
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9493
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	3	0.9476
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.9404
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	4	0.9366
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.9253
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	4	0.9216
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9214
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9201
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9173
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8978
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8941
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.8876
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.8727
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8674
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.8634
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.8605
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8558
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8556
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8508
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8504
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8496
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8492
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8482
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.8423
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8397
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8388
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.8352
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8334
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8326
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8303
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.8297
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	3	0.8286
Cytochrome P450 2E1	P05181	CP2E1_HUMAN	Homo sapiens	3	0.8233
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	4	0.8226
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	3	0.8172
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8157
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.8148
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8130
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.8105
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8095
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.8085
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.8055
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8050
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.8011
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.8008
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8001
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7993
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7937
N-alpha-acetyltransferase 50	Q9GZZ1	NAA50_HUMAN	Homo sapiens	3	0.7931
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7923
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7911
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7910
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7880
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7868
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7845
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7841
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7824
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7809
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7800
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7787
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7776
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7772
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7756
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7751
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7750
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7743
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7733
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7714
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7704
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7699
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	2	0.7686
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7684
Vitamin D(3) 25-hydroxylase	C4B644	CPVDH_PSEAH	Pseudonocardia autotrophica	3	0.7678
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7677
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7663
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7647
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7643
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7630
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7630
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7617
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7609
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7609
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7606
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7599
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7589
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7581
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7565
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7558
Putative cytochrome P450 120	Q59990	CP120_SYNY3	Synechocystis sp	3	0.7554
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7549
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7539
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	4	0.7536
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7531
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7531
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7525
Delta-type opioid receptor	P41143	OPRD_HUMAN	Homo sapiens	4	0.7511
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7511
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7502
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7499
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7495
Cellular retinoic acid-binding protein 2	P29373	RABP2_HUMAN	Homo sapiens	2	0.7495
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7493
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7490
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7477
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7461
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7436
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	2	0.7432
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7429
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7427
Cytochrome P450 3A4	P08684	CP3A4_HUMAN	Homo sapiens	3	0.7423
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7408
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7397
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7390
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7381
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7375
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	2	0.7369
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7360
Phosphoenolpyruvate carboxykinase [GTP]	P9WIH3	PCKG_MYCTU	Mycobacterium tuberculosis	3	0.7355
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	4	0.7354
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	2	0.7352
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7344
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	2	0.7342
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7342
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7334
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7330
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7326
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7320
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7317
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7303
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7298
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7297
Muconolactone Delta-isomerase	Q8G9L0	Q8G9L0_RHOOP	Rhodococcus opacus	2	0.7297
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7293
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7292
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7281
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7261
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	2	0.7261
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7258
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7253
Sulfotransferase 1E1	P49888	ST1E1_HUMAN	Homo sapiens	3	0.7248
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	2	0.7243
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7241
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7241
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7239
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	2	0.7236
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7234
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	3	0.7231
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7228
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	4	0.7224
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7223
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7218
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7215
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7213
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7206
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7205
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7205
Aldo-keto reductase family 1 member A1	P50578	AK1A1_PIG	Sus scrofa	3	0.7204
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	2	0.7199
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	2	0.7194
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7176
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7171
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7170
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7168
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	2	0.7164
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7160
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7159
Cytochrome P450 2E1	P05181	CP2E1_HUMAN	Homo sapiens	3	0.7152
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7148
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7138
Dicamba O-demethylase, oxygenase component	Q5S3I3	DDMC_STEMA	Stenotrophomonas maltophilia	2	0.7129
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7122
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.7109
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7108
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7106
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7102
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7096
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7092
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7092
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	2	0.7090
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7084
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	4	0.7083
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	2	0.7076
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7074
Alpha-tocopherol transfer protein	Q8BWP5	TTPA_MOUSE	Mus musculus	4	0.7073
Fatty acid-binding protein, intestinal	P02693	FABPI_RAT	Rattus norvegicus	3	0.7072
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7070
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7061
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7055
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7053
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7053
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7051
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7044
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7042
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7033
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7030
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7030
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	2	0.7025
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7017
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7014
Naphthalene 1,2-dioxygenase system, large oxygenase component	P0A110	NDOB_PSEPU	Pseudomonas putida	2	0.7000

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