Heitziethanoid B - Compound Card

Heitziethanoid B

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Heitziethanoid B

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Fatty Acid
Canonical Smiles CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCc1ccc(cc1)O
InChI InChI=1S/C48H88O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29-30-31-32-33-34-35-36-37-38-39-48(50)51-45-44-46-40-42-47(49)43-41-46/h40-43,49H,2-39,44-45H2,1H3
InChIKey AUUYOWKYLNLIJN-UHFFFAOYSA-N
Formula C48H88O3
HBA 3
HBD 1
MW 713.23
Rotatable Bonds 41
TPSA 46.53
LogP 16.32
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 51
Formal Charge 0
Fraction CSP3 0.85
Exact Mass 712.67
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Fagara heitzii Rutaceae Plantae —

Showing of synonyms

  • Mbaze LM, Lado JA, et al. (2009). Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae).. Phytochemistry,2009, 70(11-12), 1442-1447. [View] [PubMed]
Pubchem: 102420151
Nmrshiftdb2: 60075744

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 713.23 g/mol

Suppressive on phagocytosis response upon activation with serum

Absorption

Caco-2 (logPapp)
-4.9
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-1.96
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
349.96

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
2.76
Plasma Protein Binding
66.96
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Inhibitor

Excretion

Clearance
4.29
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-4.53
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.17
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
4.98
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-642570.91
Rat (Acute)
1.91
Rat (Chronic Oral)
3.23
Fathead Minnow
821.55
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
70502.19
Hydration Free Energy
-2.92
Log(D) at pH=7.4
10.73
Log(P)
21.05
Log S
-7.65
Log(Vapor Pressure)
-2252.85
Melting Point
97.98
pKa Acid
5.57
pKa Basic
5.59
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9755
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9657
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.9616
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9606
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9524
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9351
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9282
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9217
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9203
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.9176
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9166
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9158
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.9113
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9040
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9037
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8994
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8946
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8921
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8819
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8814
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8804
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8755
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8745
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8724
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8700
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8655
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8614
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.8608
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8544
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8506
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.8450
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8431
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8430
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.8428
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8414
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8405
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8398
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8332
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8327
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8252
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8224
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8186
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.8102
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.8039
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8026
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7992
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7979
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7954
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7953
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7891
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7884
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7882
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7856
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7847
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7842
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7829
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7808
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7793
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7791
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 3 0.7778
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7776
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7768
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7765
5'-methylthioadenosine nucleosidase Q9T0I8 MTN1_ARATH Arabidopsis thaliana 3 0.7764
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7752
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7749
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 3 0.7735
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7734
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7731
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7727
histidine kinase Q9WZV7 Q9WZV7_THEMA Thermotoga maritima 3 0.7716
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7713
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7703
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7700
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7700
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7696
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7687
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7685
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7683
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7667
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7663
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7663
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7662
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7649
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7645
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7644
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7644
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7642
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7641
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7639
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7639
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7638
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7636
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7636
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7634
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7631
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7629
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7628
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7623
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7619
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7618
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7616
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7615
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7603
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7601
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7597
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7591
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7581
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7578
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7578
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7577
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 3 0.7570
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 3 0.7569
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7568
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7558
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7557
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7554
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7551
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7549
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7546
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7546
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7546
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7544
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7534
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7531
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7530
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7530
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7526
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7521
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7518
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7515
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7515
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7509
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7508
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7507
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7500
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7498
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7497
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7495
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7493
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7491
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7488
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7488
Genome polyprotein A9LIE0 A9LIE0_9FLAV dengue virus type 3 3 0.7486
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7479
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7476
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7475
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7472
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7470
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7470
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7457
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7455
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7451
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7449
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7444
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7442
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7440
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7439
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7436
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7433
Genome polyprotein Q8QL64 Q8QL64_9FLAV Modoc virus 3 0.7433
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7431
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7429
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7427
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7427
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7427
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7422
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7422
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7419
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7418
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7418
tRNA (cytidine-2'-O-)-methyltransferase TrmJ Q4JB16 TRMJ_SULAC Sulfolobus acidocaldarius 3 0.7415
Carboxyethyl-arginine beta-lactam-synthase P0DJQ7 BLS_STRCL Streptomyces clavuligerus 3 0.7411
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 3 0.7409
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7408
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7402
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7402
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7400
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7397
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7396
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7396
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7391
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7390
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7389
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7389
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7387
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7381
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7374
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7363
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7362
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7358
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7353
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7347
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7344
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7342
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7341
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7339
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7339
tRNA-specific 2-thiouridylase MnmA Q97T38 MNMA_STRPN Streptococcus pneumoniae serotype 4 3 0.7336
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 3 0.7336
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7332
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7328
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7327
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7325
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7324
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7320
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7320
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7318
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7318
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7316
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7312
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7311
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7311
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7310
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7309
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7307
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7306
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7305
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7303
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7303
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7295
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7294
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7292
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7289
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7283
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7282
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7279
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7279
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.7279
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7277
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7273
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7272
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7272
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7270
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7269
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7268
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7267
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7266
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7263
Spermidine synthase P19623 SPEE_HUMAN Homo sapiens 3 0.7259
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7258
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7257
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7257
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7253
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7251
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7249
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7245
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7242
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7241
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7240
Cytosolic heat shock protein 90 Q7XJ80 Q7XJ80_HORVU Hordeum vulgare 3 0.7239
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7238
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.7238
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7237
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7236
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7229
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7227
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7224
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7222
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7222
Lethal factor P15917 LEF_BACAN Bacillus anthracis 2 0.7222
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7221
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7219
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7216
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7214
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7210
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7210
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7208
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7204
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7204
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7201
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7199
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7199
Aminotransferase homolog Q9S5Y7 Q9S5Y7_CAMJU Campylobacter jejuni 3 0.7197
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7193
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7192
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7191
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7190
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 3 0.7186
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7185
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7185
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7184
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7182
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7181
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7179
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 2 0.7178
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7176
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7173
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7171
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7170
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7169
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7161
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7160
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7160
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 2 0.7159
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7159
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7156
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7154
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7149
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7148
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7146
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7142
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7141
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7138
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7132
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7130
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7129
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7127
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7127
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7126
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7126
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 2 0.7124
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 2 0.7121
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7121
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7118
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7116
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7116
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7114
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7112
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7111
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7110
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7108
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7105
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7102
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7101
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7101
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 O95340 PAPS2_HUMAN Homo sapiens 2 0.7101
Class B acid phosphatase P0AE22 APHA_ECOLI Escherichia coli 2 0.7100
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7100
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7099
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7099
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7097
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7097
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7096
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7095
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7092
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7090
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7089
adenine phosphoribosyltransferase Q967M2 Q967M2_GIAIN Giardia intestinalis 2 0.7085
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7084
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7075
Protein translocase subunit SecA P10408 SECA_ECOLI Escherichia coli 3 0.7070
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7070
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7070
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7070
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7068
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7066
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7064
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7062
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7060
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7060
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7058
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7055
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7055
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7053
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7051
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 2 0.7051
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 2 0.7051
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7048
Unconventional myosin-Va Q02440 MYO5A_CHICK Gallus gallus 2 0.7047
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7047
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7045
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7045
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7045
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7043
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7043
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7041
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7033
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7029
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7026
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 2 0.7026
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7025
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7021
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7017
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7017
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 2 0.7017
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7014
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7014
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7012
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7010
Rac-like GTP-binding protein ARAC7 O82480 RAC7_ARATH Arabidopsis thaliana 3 0.7009
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 2 0.7008
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7006
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7006
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7005
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 3 0.7004
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7003
Cobalamin synthesis related protein Q6NIF5 Q6NIF5_CORDI Corynebacterium diphtheriae 3 0.7000

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