Tessmamide - Compound Card

Tessmamide

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Tessmamide

Structure
Zoomed Structure
  • Family: Rutaceae
  • Kingdom: Plantae
  • Class: Aromatic Amide
Canonical Smiles COc1ccccc1N(C(=O)c1ccc(c2c1OCO2)OC)C
InChI InChI=1S/C17H17NO5/c1-18(12-6-4-5-7-13(12)20-2)17(19)11-8-9-14(21-3)16-15(11)22-10-23-16/h4-9H,10H2,1-3H3
InChIKey UZEJJSAHIZHQPC-UHFFFAOYSA-N
Formula C17H17NO5
HBA 5
HBD 0
MW 315.33
Rotatable Bonds 4
TPSA 57.23
LogP 2.71
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 315.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Zanthoxylum tessmannii Rutaceae Plantae 1291627

Showing of synonyms

  • Kenmoe Djeukeu C, Kouam Kenmogne A, et al. (2019). A New Aromatic Amide from the Roots of Zanthoxylum tessmannii (Rutaceae).. Chemistry & biodiversity,2019, 16(4), e1800590. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1NC(=O)c2cccc(c23)OCO3

Level: 1

Mol. Weight: 241.25 g/mol

Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 122.12 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Antioxidant

Absorption

Caco-2 (logPapp)
-4.59
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.280
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.76

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.340
Plasma Protein Binding
51.77
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.050
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.470
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.420
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.030
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.510
Rat (Acute)
2.170
Rat (Chronic Oral)
1.710
Fathead Minnow
4.860
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
390.160
Hydration Free Energy
-9.060
Log(D) at pH=7.4
2.430
Log(P)
2.94
Log S
-3.87
Log(Vapor Pressure)
-6.03
Melting Point
98.3
pKa Acid
9.31
pKa Basic
-0.48
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9861
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9771
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9760
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9715
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9677
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9648
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9486
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9472
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9417
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9416
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9414
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9413
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9395
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9387
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9369
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.9285
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9246
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9233
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9194
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9155
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9139
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9116
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.9113
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9109
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9108
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9099
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9098
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.9072
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9048
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9037
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.9014
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8956
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8917
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8914
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8914
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8911
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8894
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8889
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8868
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.8855
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8843
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8836
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8821
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8772
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8753
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8747
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8737
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.8731
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8714
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8689
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8630
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8624
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8613
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8571
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8556
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8554
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8543
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8539
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8492
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8484
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8416
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8395
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8388
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8387
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8352
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.8350
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8336
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8329
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8303
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8293
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8218
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.8213
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8188
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8183
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8115
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8113
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8109
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8106
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8105
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8101
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8085
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8050
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.8044
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8022
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.8021
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8017
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.8012
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.8011
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8006
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8004
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7990
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7988
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7981
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7977
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7976
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7970
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7964
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7954
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7949
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7944
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7941
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.7939
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7935
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7920
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7916
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7891
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7888
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7884
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7883
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7868
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7859
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7852
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7850
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7839
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7835
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7809
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7804
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7800
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7797
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7796
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7792
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7791
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7790
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7778
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7765
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7764
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7758
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7758
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7737
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7737
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7736
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7733
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7728
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7726
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7724
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7721
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7715
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7712
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7710
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7709
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7704
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7703
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7699
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7697
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7696
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7696
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7695
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7689
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7687
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7684
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7667
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7666
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7664
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7663
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7662
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7660
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7657
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7642
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7639
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7626
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7624
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7623
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7623
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7621
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7620
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7613
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7611
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7603
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7603
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7595
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7595
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7586
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7585
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7583
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7581
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7581
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7580
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7580
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7578
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7560
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7554
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7553
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7553
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7553
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7551
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7544
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7543
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7542
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7541
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7540
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7538
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7533
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7532
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7527
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7525
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7521
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 2 0.7515
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7515
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7514
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7512
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7506
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7505
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7504
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7504
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7501
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7500
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7500
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7490
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7485
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7483
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7480
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7478
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7477
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 2 0.7468
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7463
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7461
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 2 0.7461
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7458
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7457
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7444
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7444
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7444
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7441
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7439
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7431
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7418
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7410
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7410
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7407
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7403
Large structural protein Q91L20 Q91L20_9MONO Human metapneumovirus 3 0.7403
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7403
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7402
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7396
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7395
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7394
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7393
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7392
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7391
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7390
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7388
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7387
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7386
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7377
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7377
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7374
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7374
tRNA (guanine-N(1)-)-methyltransferase P43912 TRMD_HAEIN Haemophilus influenzae 4 0.7367
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7367
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7367
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7360
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7358
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7354
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7351
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7348
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7348
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7347
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7340
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7332
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7330
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7329
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7328
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7325
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7321
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7319
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7318
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7317
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7314
Phospholipase A2, membrane associated P14555 PA2GA_HUMAN Homo sapiens 2 0.7312
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7310
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7308
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7305
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7301
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7298
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7298
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7296
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7291
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7291
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7290
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7289
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7289
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7289
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7288
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7286
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7282
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7280
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7280
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7279
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7279
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7273
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7269
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7269
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7266
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 2 0.7265
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7263
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7263
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7263
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7260
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7259
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7254
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7252
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7251
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7246
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7241
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7241
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7237
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7231
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7231
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7228
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7227
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7224
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 2 0.7224
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7224
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7222
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7221
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7218
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7215
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7215
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7212
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7211
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7207
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7197
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7191
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7187
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7186
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7185
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7185
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7185
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7185
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7185
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7178
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7178
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7177
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7177
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7175
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7175
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7173
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7173
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7172
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7171
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7168
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7165
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7162
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7162
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7160
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7160
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7160
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7157
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7157
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7150
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7145
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7145
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7143
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7143
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7142
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7140
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7137
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7135
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7134
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7133
UDP-N-acetylglucosamine 1-carboxyvinyltransferase P33038 MURA_ENTCC Enterobacter cloacae subsp. cloacae 2 0.7131
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7127
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7124
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7120
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7108
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7108
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7106
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7104
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7102
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7099
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7097
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7097
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7094
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7092
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7088
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7084
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7084
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7079
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7077
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7075
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7073
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7070
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7066
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7065
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7064
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 2 0.7064
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7063
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7063
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7060
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7059
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7059
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7051
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P9WQ81 BIOA_MYCTU Mycobacterium tuberculosis 3 0.7047
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7047
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7045
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7043
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7043
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7042
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7042
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7038
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7038
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7038
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7032
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 3 0.7027
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7027
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7024
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7022
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7018
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7016
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7016
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7014
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7014
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7013
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7013
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7006
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7005

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