N-benzoyltyramine methyl ether - Compound Card

N-benzoyltyramine methyl ether

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N-benzoyltyramine methyl ether

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkamide
Canonical Smiles COc1ccc(cc1)CCNC(=O)c1ccccc1
InChI InChI=1S/C16H17NO2/c1-19-15-9-7-13(8-10-15)11-12-17-16(18)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,17,18)
InChIKey RAOWOXJDGFFKKD-UHFFFAOYSA-N
Formula C16H17NO2
HBA 2
HBD 1
MW 255.32
Rotatable Bonds 5
TPSA 38.33
LogP 2.67
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 255.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Zanthoxylum tessmannii Rutaceae Plantae 1291627

Showing of synonyms

  • Kenmoe Djeukeu C, Kouam Kenmogne A, et al. (2019). A New Aromatic Amide from the Roots of Zanthoxylum tessmannii (Rutaceae).. Chemistry & biodiversity,2019, 16(4), e1800590. [View] [PubMed]
Pubchem: 3083797
Chebi: 157736
Nmrshiftdb2: 60074864

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)NCCc2ccccc2

Level: 1

Mol. Weight: 255.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 255.32 g/mol

Antioxidant

Absorption

Caco-2 (logPapp)
-4.62
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.260
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.88

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.860
Plasma Protein Binding
70.53
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.020
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.250
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.740
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.950
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.600
Rat (Acute)
1.440
Rat (Chronic Oral)
1.890
Fathead Minnow
4.320
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
352.520
Hydration Free Energy
-11.760
Log(D) at pH=7.4
2.750
Log(P)
2.73
Log S
-3.33
Log(Vapor Pressure)
-6.05
Melting Point
100.83
pKa Acid
12.44
pKa Basic
3.62
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.9895
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9759
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.9752
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9745
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9643
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9627
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.9621
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9572
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9564
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.9547
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9502
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9385
Protein-tyrosine kinase 2-beta Q14289 FAK2_HUMAN Homo sapiens 4 0.9383
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9329
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9319
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9306
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9297
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9296
Inorganic pyrophosphatase Q3JUV5 Q3JUV5_BURP1 Burkholderia pseudomallei 3 0.9293
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9289
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9278
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.9267
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9266
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.9238
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9227
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.9222
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9190
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9156
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9133
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9123
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9112
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.9109
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.9096
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9088
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9081
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 4 0.9067
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9045
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9043
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.9022
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9021
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9019
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9017
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8993
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8988
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8979
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8967
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8945
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8929
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8901
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.8876
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8870
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8869
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8866
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8859
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8844
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8844
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8836
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8798
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8785
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.8784
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8783
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8763
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.8756
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.8739
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8693
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8631
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8611
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.8589
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8580
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8576
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8542
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8525
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.8517
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8504
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.8490
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8483
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8474
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8472
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8416
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8416
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.8415
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8378
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8357
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8319
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8311
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8303
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8297
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8278
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.8270
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8257
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8257
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8255
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.8248
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8236
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8233
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8222
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8219
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8213
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8205
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8184
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8168
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8159
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8153
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8140
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8130
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8129
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8118
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8107
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8107
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8099
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8095
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8058
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8057
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8028
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8022
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8018
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8013
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8011
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7997
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7996
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7967
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7962
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 4 0.7959
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7956
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7942
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7941
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7919
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7906
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7895
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7887
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7886
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7883
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7877
Interleukin-1 receptor-associated kinase 4 Q9NWZ3 IRAK4_HUMAN Homo sapiens 3 0.7873
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 2 0.7867
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7861
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7846
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7835
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7833
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7824
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7812
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7805
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7789
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7788
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7785
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7784
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7781
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7760
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7753
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7737
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7735
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7731
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7727
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7726
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7702
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7699
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7698
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7695
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7686
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7681
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7678
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7675
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7668
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7660
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7655
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7654
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7649
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7646
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7645
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7641
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7639
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7633
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7623
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7621
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7611
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7600
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7596
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7593
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7592
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7592
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7590
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7584
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7580
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7576
Mitogen-activated protein kinase 14 P47811 MK14_MOUSE Mus musculus 3 0.7564
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7555
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7553
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7553
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7552
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7551
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7549
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7548
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 3 0.7542
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7541
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7541
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7534
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 2 0.7534
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7529
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7529
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7524
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7522
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7521
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7519
Purine nucleoside phosphorylase Q9BMI9 Q9BMI9_SCHMA Schistosoma mansoni 2 0.7518
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7517
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7515
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7511
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7507
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7506
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7504
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7503
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7500
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7498
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7489
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7484
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7481
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7480
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7479
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7464
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7463
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7462
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7460
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7460
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7459
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7456
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7455
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7449
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7447
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7446
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7444
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7441
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7441
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7439
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7438
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7437
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7437
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7435
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7433
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7429
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7428
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7427
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7418
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7414
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7412
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7412
Probable flavin-dependent thymidylate synthase O41156 THYX_PBCV1 Paramecium bursaria Chlorella virus 1 3 0.7410
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7408
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7408
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7400
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 2 0.7399
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7396
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7393
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7393
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7392
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 2 0.7389
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7386
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7386
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7380
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7380
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7375
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7369
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7368
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7366
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7360
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7356
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7355
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7354
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7354
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 2 0.7353
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7351
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 2 0.7351
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7351
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7350
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7349
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7348
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.7348
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7347
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7345
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 2 0.7343
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7343
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7340
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 3 0.7338
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7338
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7338
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7336
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7334
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7332
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7332
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7331
Peroxisome proliferator-activated receptor delta Q03181 PPARD_HUMAN Homo sapiens 2 0.7329
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7325
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7325
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7324
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7323
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7321
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 2 0.7321
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7320
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7318
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7314
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7314
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 2 0.7312
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7312
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7312
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7311
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7310
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7310
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7309
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7308
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7307
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7306
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7305
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7300
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7299
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7299
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 3 0.7298
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7297
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7297
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7296
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7295
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7294
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7294
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7291
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7290
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7286
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7282
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7281
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7280
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7278
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7277
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7276
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7272
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7265
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7259
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7259
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7257
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7255
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7252
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7251
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7251
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7250
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7250
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7245
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7244
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7243
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7242
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7241
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7237
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7233
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7232
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7230
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7228
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7228
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7224
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7222
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7222
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7221
Glycylpeptide N-tetradecanoyltransferase A5K1A2 A5K1A2_PLAVS Plasmodium vivax 2 0.7221
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7215
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7215
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7215
Adenine DNA glycosylase P83847 MUTY_GEOSE Geobacillus stearothermophilus 3 0.7214
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7212
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7212
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7210
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7210
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7209
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7209
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7208
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7208
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7206
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7202
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7192
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7191
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7190
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7190
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7190
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7187
Endoglycoceramidase II O33853 O33853_RHOSO Rhodococcus sp 3 0.7186
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7184
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7184
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7183
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7182
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7180
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7178
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 2 0.7173
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7171
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7171
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7169
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7168
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7163
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7162
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7160
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7159
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7155
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7153
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7152
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7152
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7152
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7150
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7149
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7149
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 3 0.7148
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7148
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7147
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7146
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7146
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7140
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7138
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7134
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7128
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7123
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7123
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7115
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7115
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7115
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7113
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7111
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7108
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7108
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7108
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7107
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7105
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7105
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7102
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7101
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7101
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7099
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7098
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7097
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7094
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7094
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7094
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7093
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7092
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7090
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7089
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7087
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7087
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7085
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7084
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7081
Orf1ab polyprotein Q6T1E9 Q6T1E9_CVHSA SARS coronavirus CUHK-L2 3 0.7081
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7080
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7080
Pol polyprotein Q90K99 Q90K99_9HIV1 Human immunodeficiency virus 1 3 0.7079
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7079
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7079
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7077
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7075
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7073
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7072
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7072
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7071
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 2 0.7067
Signaling protein P83820 P83820_THETH Thermus thermophilus 3 0.7063
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7062
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7060
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 2 0.7059
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7059
ATP-dependent Clp protease ATP-binding subunit ClpX O25926 CLPX_HELPY Helicobacter pylori 3 0.7055
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7055
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7047
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7046
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 2 0.7043
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7043
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7041
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7041
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7039
Serine/threonine-protein kinase CtkA Q9ZKJ5 CTKA_HELPJ Helicobacter pylori 3 0.7038
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7036
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7035
Class B acid phosphatase P0AE22 APHA_ECOLI Escherichia coli 2 0.7034
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7033
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7031
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 2 0.7031
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7029
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7028
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 2 0.7027
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7024
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7024
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7019
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7018
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7016
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7015
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7014
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7012
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7012
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7009
4-substituted benzoates-glutamate ligase GH3.12 Q9LYU4 GH312_ARATH Arabidopsis thaliana 2 0.7009
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7009
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7008
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7004
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7003
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7000

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