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Soyauxinine

Family: Plantae - Rutaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indolopyridoquinazoline

Canonical Smiles	COc1ccc(c(c1)NC)C(=O)N1CCc2c(C1=O)[nH]c1c2cccc1
InChI	InChI=1S/C20H19N3O3/c1-21-17-11-12(26-2)7-8-15(17)19(24)23-10-9-14-13-5-3-4-6-16(13)22-18(14)20(23)25/h3-8,11,21-22H,9-10H2,1-2H3
InChIKey	PHGAJNNMRPOUGW-UHFFFAOYSA-N
Formula	C₂₀H₁₉N₃O₃
HBA	4
HBD	2
MW	349.39
Rotatable Bonds	3
TPSA	74.43
LogP	3.06
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	26
Formal Charge	0
Fraction CSP3	0.2
Exact Mass	349.14
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Araliopsis soyauxii	Rutaceae	Plantae	1317904

Showing of synonyms

Noulala CGT, Ouete JLN, et al. (2022). Soyauxinine, a New Indolopyridoquinazoline Alkaloid from the Stem Bark of Araliopsis soyauxii Engl. (Rutaceae). Molecules. 2022, 27(3), 1104. [View] [PubMed]

CPRiL: 456324

SMILES: c1ccccc1C(=O)N(CC2)C(=O)c(c2c34)[nH]c3cccc4

Level: 1

Mol. Weight: 349.39 g/mol

SMILES: C1CNC(=O)c(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 349.39 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 349.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.92
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.810
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.47

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.910
Plasma Protein Binding: 57.11
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.380
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.550
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.490
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.720
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -4.570
Rat (Acute): 2.080
Rat (Chronic Oral): 2.060
Fathead Minnow: 4.520
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 468.380
Hydration Free Energy: -9.270
Log(D) at pH=7.4: 3.730
Log(P): 3.56
Log S: -6.76
Log(Vapor Pressure): -9.7
Melting Point: 204.69
pKa Acid: 12.15
pKa Basic: 6.52

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.9531
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9430
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.9342
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9272
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9257
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9256
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.9172
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9169
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.9149
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9135
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.9118
Aklanonic acid methyl ester cyclase AcmA	O52646	DNRD_STRGJ	Streptomyces galilaeus	3	0.9090
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.9042
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8975
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8956
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.8956
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.8907
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8889
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8874
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8862
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8855
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8839
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8833
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.8814
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8810
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8785
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8744
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8694
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8693
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8684
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8652
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8645
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.8624
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8605
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.8599
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.8597
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.8585
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8568
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8567
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.8566
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8564
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8547
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8543
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8510
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.8506
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8500
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8461
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8414
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.8412
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8396
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8365
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8362
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.8357
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8357
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8356
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	4	0.8344
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8319
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8286
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.8281
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8273
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8272
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.8268
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8263
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8237
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8194
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8187
Enoyl-[acyl-carrier-protein] reductase [NADH]	Q5NGQ3	Q5NGQ3_FRATT	Francisella tularensis subsp. tularensis	3	0.8184
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8182
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8176
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8147
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.8133
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8128
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8110
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8106
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8090
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8051
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8046
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8044
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8023
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8016
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8015
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.8011
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7978
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7944
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7934
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7921
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7917
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7911
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7907
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7890
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7886
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7885
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7848
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7827
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7801
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7798
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7739
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	3	0.7730
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7730
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7728
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7722
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7712
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7708
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7706
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7693
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7691
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7691
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7681
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7673
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7672
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7660
Lanosterol 14-alpha demethylase	A6ZSR0	A6ZSR0_YEAS7	Saccharomyces cerevisiae	3	0.7651
Lanosterol synthase	P48449	ERG7_HUMAN	Homo sapiens	3	0.7616
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7615
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7607
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7602
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7598
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7596
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	4	0.7590
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7580
Enoyl-acyl carrier reductase	C6KSZ2	C6KSZ2_PLAF7	Plasmodium falciparum	4	0.7579
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7577
Beta-elicitin cryptogein	P15570	ELIB_PHYCR	Phytophthora cryptogea	3	0.7568
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7568
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7568
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7558
Alcohol dehydrogenase 1C	P00326	ADH1G_HUMAN	Homo sapiens	2	0.7549
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7534
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7533
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7531
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7520
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7517
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7516
Genome polyprotein	C0LMU0	C0LMU0_9FLAV	dengue virus type 3	3	0.7509
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7497
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7494
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7480
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7472
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7471
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7470
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7469
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7467
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7461
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7457
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7454
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7453
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7448
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7448
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7447
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7443
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7437
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7427
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7423
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7416
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7407
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7402
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7386
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7384
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.7377
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7374
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7373
Myosin-2 heavy chain	P08799	MYS2_DICDI	Dictyostelium discoideum	4	0.7370
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7368
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7360
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7356
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7351
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7349
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7346
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7336
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7335
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7331
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7319
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7318
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7314
Glycogen phosphorylase, liver form	P06737	PYGL_HUMAN	Homo sapiens	3	0.7306
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7302
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7300
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7299
Orf1ab polyprotein	Q6T1E9	Q6T1E9_CVHSA	SARS coronavirus CUHK-L2	3	0.7296
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7293
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7293
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	3	0.7293
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7292
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7289
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7280
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7279
Cyclic GMP-AMP synthase	Q8C6L5	CGAS_MOUSE	Mus musculus	3	0.7277
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7273
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7255
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7250
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7248
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7244
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7242
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	4	0.7235
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7235
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7232
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7228
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7223
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.7222
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7219
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7216
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7213
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7207
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7195
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	2	0.7190
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7189
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7185
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	3	0.7181
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7181
GTPase IMAP family member 2	Q9UG22	GIMA2_HUMAN	Homo sapiens	3	0.7181
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7172
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7168
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7166
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7161
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7159
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7155
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7152
Periplasmic pH-dependent serine endoprotease DegQ	P39099	DEGQ_ECOLI	Escherichia coli	3	0.7150
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7150
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7149
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7148
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7147
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7146
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	4	0.7143
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7142
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7139
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7131
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7131
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7126
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7124
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7124
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7113
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7113
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7111
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7107
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7105
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7104
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7103
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7099
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7095
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7091
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7089
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7080
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7077
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	4	0.7076
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7076
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7073
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7070
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7063
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7057
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7056
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	4	0.7055
3',5'-cyclic-AMP phosphodiesterase 4B	Q07343	PDE4B_HUMAN	Homo sapiens	3	0.7047
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	2	0.7047
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7044
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7044
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	4	0.7043
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7039
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7032
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7031
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7030
Putative lanosterol 14-alpha-demethylase	A2TEF2	A2TEF2_LEIIN	Leishmania infantum	3	0.7027
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7026
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7018
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7017
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7014
Ribonuclease TTHA0252	Q5SLP1	RNSE_THET8	Thermus thermophilus	3	0.7013
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7011
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7010
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7007
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7006
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7005
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7004
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7003
Endoplasmic reticulum aminopeptidase 2	Q6P179	ERAP2_HUMAN	Homo sapiens	2	0.7003
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7002

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