Soyauxinium nitrate - Compound Card

Soyauxinium nitrate

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Soyauxinium nitrate

Structure
Zoomed Structure
  • Family: Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles c1c(cc2c(c1)c(=O)n1c([n+]2C)c2c(CC1)c1c([nH]2)cccc1)OC
InChI InChI=1S/C20H17N3O2/c1-22-17-11-12(25-2)7-8-15(17)20(24)23-10-9-14-13-5-3-4-6-16(13)21-18(14)19(22)23/h3-8,11H,9-10H2,1-2H3/p+1
InChIKey DXEQMLVCHAWCCB-UHFFFAOYSA-O
Formula C20H18N3O2+
HBA 3
HBD 1
MW 332.38
Rotatable Bonds 1
TPSA 50.9
LogP 2.54
Number Rings 5
Number Aromatic Rings 4
Heavy Atom Count 25
Formal Charge 1
Fraction CSP3 0.2
Exact Mass 332.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Araliopsis soyauxii Rutaceae Plantae 1317904

Showing of synonyms

  • Noulala CGT, Ouete JLN, et al. (2022). Soyauxinine, a New Indolopyridoquinazoline Alkaloid from the Stem Bark of Araliopsis soyauxii Engl. (Rutaceae). Molecules. 2022, 27(3), 1104. [View] [PubMed]
Pubchem: 11132332

No compound-protein relationship available.

Structure

SMILES: c1cccc2[nH]c(c3c12)c4n(CC3)c(=O)c5c([nH+]4)cccc5

Level: 0

Mol. Weight: 288.33 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.79
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.31
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.91

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.66
Plasma Protein Binding
67.31
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.41
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.78
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.54
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.21
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-3.42
Rat (Acute)
2.69
Rat (Chronic Oral)
1.41
Fathead Minnow
5.15
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
476.07
Hydration Free Energy
-6.95
Log(D) at pH=7.4
3.04
Log(P)
0.35
Log S
-2.25
Log(Vapor Pressure)
-10.25
Melting Point
299.37
pKa Acid
7.58
pKa Basic
6.11
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9793
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9568
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9546
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9466
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9454
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9406
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9360
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9231
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9157
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9147
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9064
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8990
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8984
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8975
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8942
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8930
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8918
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8905
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8825
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8806
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8790
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8751
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8727
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8705
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8704
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8692
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8665
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8615
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8607
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8596
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8582
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8553
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8545
AGAP001556-PA Q7PXT9 Q7PXT9_ANOGA Anopheles gambiae 3 0.8434
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 4 0.8430
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8407
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8378
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8374
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8363
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8346
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8316
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8299
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.8289
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8273
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.8245
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8197
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8187
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8175
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8171
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8145
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8141
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8128
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8109
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8103
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8075
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8063
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8043
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8034
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8014
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8008
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8006
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7972
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7970
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7964
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7952
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7950
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7919
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7910
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7906
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7900
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7895
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7872
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7863
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7857
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7827
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7820
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7813
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7803
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7787
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7784
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7782
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7779
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7779
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7765
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7750
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7745
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7743
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7731
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7719
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7715
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7704
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7689
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 4 0.7673
Heat shock protein 83 Q389P1 Q389P1_TRYB2 Trypanosoma brucei brucei 4 0.7662
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7661
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7651
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7650
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7647
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7606
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 3 0.7600
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7596
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7582
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7569
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7568
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7559
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7534
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7534
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7527
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7522
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7519
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7505
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7503
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7497
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7495
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7482
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 4 0.7482
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7477
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7461
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7459
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7453
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7450
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7434
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7420
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7418
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7415
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7409
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7404
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7402
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7401
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7397
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7397
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7395
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7385
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7358
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 3 0.7351
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 4 0.7342
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7342
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7332
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7332
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7327
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7313
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7313
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7303
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7302
Lanosterol 14-alpha demethylase A6ZSR0 A6ZSR0_YEAS7 Saccharomyces cerevisiae 3 0.7296
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7284
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7278
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7277
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7273
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7260
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7247
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7245
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7240
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7235
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7229
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7229
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7223
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 4 0.7219
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7217
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7208
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7206
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7206
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7200
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7194
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7191
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7187
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7182
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7180
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7179
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7175
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7175
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7169
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7163
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7163
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7161
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7153
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7147
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7132
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7129
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7128
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7128
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 4 0.7122
Cytochrome P450 J9JD66 J9JD66_NEOLE Neotoma lepida 4 0.7118
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7113
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7112
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 3 0.7110
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7108
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7097
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7086
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7085
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7085
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7065
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7063
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7063
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7060
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7058
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7053
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7052
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7041
Putative mitogen-activated protein kinase Q4QHJ8 Q4QHJ8_LEIMA Leishmania major 3 0.7035
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7028
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7028
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7028
Sterol 14-alpha demethylase Q7Z1V1 CP51_TRYCC Trypanosoma cruzi 3 0.7022
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7017
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7016
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7015
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7013
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.7006
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7004
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7002

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