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Seputhecarpan C

Family: Plantae - Sapotaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Pterocarpan

Canonical Smiles	OCC(=C)C1Oc2c(C1)cc1c(c2)OCC2C1Oc1c2ccc(c1)OC
InChI	InChI=1S/C21H20O5/c1-11(9-22)17-6-12-5-15-19(8-18(12)25-17)24-10-16-14-4-3-13(23-2)7-20(14)26-21(15)16/h3-5,7-8,16-17,21-22H,1,6,9-10H2,2H3
InChIKey	DCMXCEWZKVNDFI-UHFFFAOYSA-N
Formula	C₂₁H₂₀O₅
HBA	5
HBD	1
MW	352.39
Rotatable Bonds	3
TPSA	57.15
LogP	3.16
Number Rings	5
Number Aromatic Rings	2
Heavy Atom Count	26
Formal Charge	0
Fraction CSP3	0.33
Exact Mass	352.13
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Synsepalum zenkeri	Sapotaceae	Plantae	233754

Showing of synonyms

Kuete V, Ngnintedo D, et al. (2018). Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells.. BMC complementary and alternative medicine,2018, 18(1), 36. [View] [PubMed]

No compound-protein relationship available.

SMILES: c1cccc(c12)OC3C2COc4c3cc5c(c4)OCC5

Level: 0

Mol. Weight: 352.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.01
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.48
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.27

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.24
Plasma Protein Binding: 40.16
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 14.52
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.48
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.35
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.8
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -6.34
Rat (Acute): 2.85
Rat (Chronic Oral): 1.61
Fathead Minnow: 5.03
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 457.31
Hydration Free Energy: -6.6
Log(D) at pH=7.4: 3.01
Log(P): 3.43
Log S: -4.02
Log(Vapor Pressure): -9.13
Melting Point: 141.95
pKa Acid: 11.81
pKa Basic: 5.78

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9439
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9437
Aldehyde dehydrogenase, dimeric NADP-preferring	P30838	AL3A1_HUMAN	Homo sapiens	3	0.9425
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.9300
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.9278
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9227
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9208
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9196
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.9161
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.9010
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.8996
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8982
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.8970
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8962
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8944
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.8857
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.8791
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8750
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8709
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8704
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.8690
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8689
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.8578
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8560
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8546
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8522
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.8471
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8418
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.8341
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8335
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.8309
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8251
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8243
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8238
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8157
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8136
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8076
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8072
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	3	0.8062
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8033
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8015
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7957
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7941
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7935
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7926
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	4	0.7888
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7867
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7837
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7836
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7829
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7816
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7815
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7803
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7803
Enoyl-[acyl-carrier-protein] reductase [NADH]	Q5NGQ3	Q5NGQ3_FRATT	Francisella tularensis subsp. tularensis	3	0.7796
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7781
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7774
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7751
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	3	0.7750
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7734
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7728
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7723
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7719
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7716
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.7715
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	3	0.7714
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7704
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7669
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7652
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7645
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7641
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q9R1E6	ENPP2_MOUSE	Mus musculus	3	0.7630
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7625
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7619
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7613
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7609
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7592
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7580
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7563
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7558
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7556
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7550
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7547
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7545
Squalene synthase	P37268	FDFT_HUMAN	Homo sapiens	3	0.7542
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7531
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7529
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7522
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7509
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7494
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7492
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7473
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7457
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7455
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7454
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	2	0.7448
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7436
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7434
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7433
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7427
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7420
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7417
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7416
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7408
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7395
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7391
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7387
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	3	0.7369
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7357
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7356
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7341
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7340
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7337
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7337
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7337
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7335
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.7333
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7329
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7305
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7300
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7292
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7292
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7291
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7290
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7287
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7285
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7282
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7281
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7278
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7276
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7259
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7258
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7239
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	4	0.7238
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7236
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7229
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7228
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7225
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7223
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7214
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7210
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7209
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7207
Lanosterol synthase	P48449	ERG7_HUMAN	Homo sapiens	3	0.7206
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7194
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7192
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.7188
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7181
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7181
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	4	0.7166
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7152
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7151
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7148
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7139
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7139
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7118
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7116
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7115
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7104
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7102
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7096
Snake venom metalloproteinase atrolysin-D	P15167	VM1AD_CROAT	Crotalus atrox	2	0.7093
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7086
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7080
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7075
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7070
Isoflavone 4'-O-methyltransferase	Q29U70	I4OMT_MEDTR	Medicago truncatula	4	0.7067
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7062
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	2	0.7060
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7051
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.7045
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7001

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