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Heterophynone

Family: Sterculiaceae
Kingdom: Plantae
Class: Terpenoid
- Subclass: Pentacyclic Triterpenoid

Canonical Smiles	CCCCCc1cc(OC)cc(c1c1oc2cc(OC)cc(c2c(=O)c1O)CCCCC)O
InChI	InChI=1S/C27H34O6/c1-5-7-9-11-17-13-19(31-3)15-21(28)23(17)27-26(30)25(29)24-18(12-10-8-6-2)14-20(32-4)16-22(24)33-27/h13-16,28,30H,5-12H2,1-4H3
InChIKey	BHQQDOAHSFFCFD-UHFFFAOYSA-N
Formula	C₂₇H₃₄O₆
HBA	6
HBD	2
MW	454.56
Rotatable Bonds	11
TPSA	89.13
LogP	6.35
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	33
Formal Charge	0
Fraction CSP3	0.44
Exact Mass	454.24
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Cola heterophylla	Sterculiaceae	Plantae	82456

Showing of synonyms

Noah MM, Tagatsing Fotsing M, et al. (2022). Heterophynone and methyl ester of Colic acid, two new compounds with antimicrobial activity from Cola heterophylla (Sterculiaceae).. Natural product research,2022, 36(1), 246-255. [View] [PubMed]

Pubchem: 171120339

No compound-protein relationship available.

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.84
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.79
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.19

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.58
Plasma Protein Binding: 87.65
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 2.97
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.96
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.96
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.92
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -110.54
Rat (Acute): 2.1
Rat (Chronic Oral): 2.55
Fathead Minnow: 5.17
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 500.69
Hydration Free Energy: -3.26
Log(D) at pH=7.4: 4.17
Log(P): 7.13
Log S: -6.09
Log(Vapor Pressure): -9.09
Melting Point: 127.95
pKa Acid: 7.39
pKa Basic: 7.06

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9733
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9556
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9381
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9297
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9265
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9263
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.9171
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.9154
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.9140
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.9071
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8985
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8958
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8956
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8944
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8942
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8920
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	5	0.8907
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8906
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8898
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8878
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8872
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.8839
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8828
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8805
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8777
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8761
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8761
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8735
Phosphatidylinositol 3-kinase catalytic subunit type 3	Q8NEB9	PK3C3_HUMAN	Homo sapiens	4	0.8721
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8717
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8712
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8710
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	5	0.8700
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8695
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8671
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8625
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8614
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8607
Renin	P00797	RENI_HUMAN	Homo sapiens	3	0.8562
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8559
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8552
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8476
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8468
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8448
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8433
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8411
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8387
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8385
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.8346
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8332
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8323
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8313
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8301
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8293
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8291
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8225
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8208
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8201
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8199
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8189
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.8189
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8185
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8184
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.8167
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8161
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8155
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.8149
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8142
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8133
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8114
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.8111
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8107
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8103
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.8102
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.8101
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.8094
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8062
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8050
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.8046
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.8043
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8039
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8034
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8030
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8022
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.8014
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8011
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8009
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8001
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7986
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7975
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7969
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	5	0.7959
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7952
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7941
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7941
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7941
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7929
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7922
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7895
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7883
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7858
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7857
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7824
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7823
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7820
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7817
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7793
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	4	0.7782
Casein kinase I isoform delta	P48730	KC1D_HUMAN	Homo sapiens	3	0.7782
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7726
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7722
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7694
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7693
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	4	0.7690
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7690
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7680
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7672
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7668
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	O35904	PK3CD_MOUSE	Mus musculus	4	0.7667
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7665
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7633
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7631
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7611
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7582
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	5	0.7581
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7579
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7577
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7571
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7568
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7565
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7557
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7555
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7550
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7550
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7544
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	5	0.7539
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.7536
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7536
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7526
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7522
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7522
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7512
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7505
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7500
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7497
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7496
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	4	0.7472
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7470
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7466
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.7464
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7454
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7445
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7441
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7434
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7428
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7426
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	5	0.7421
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7420
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7417
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7415
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7415
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7407
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7406
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7406
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7405
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.7403
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.7402
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7401
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7400
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7397
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7397
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7393
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7391
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7390
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7381
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7374
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	3	0.7369
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7368
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7364
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7359
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7356
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7345
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7343
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7342
Casein kinase I isoform delta	P48730	KC1D_HUMAN	Homo sapiens	3	0.7336
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7333
Quercetin 2,3-dioxygenase	Q7SIC2	QDOI_ASPJA	Aspergillus japonicus	4	0.7333
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7328
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7327
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7326
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7322
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7315
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7310
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7303
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7292
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7287
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7285
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7283
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7281
Delta-type opioid receptor	P41143	OPRD_HUMAN	Homo sapiens	4	0.7275
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	4	0.7268
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7267
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7266
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	3	0.7260
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7259
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	4	0.7258
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7252
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7251
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7245
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7241
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7240
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7238
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7235
Heat shock protein 75 kDa, mitochondrial	Q12931	TRAP1_HUMAN	Homo sapiens	3	0.7234
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7233
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7225
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7218
Cyclin-dependent kinase 5	Q00535	CDK5_HUMAN	Homo sapiens	4	0.7217
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7207
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	2	0.7205
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7204
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	5	0.7201
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	4	0.7200
Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	PAR10_HUMAN	Homo sapiens	3	0.7197
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7195
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7181
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7175
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7174
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7174
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7172
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7169
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7167
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7166
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7161
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7156
Flavin reductase (NADPH)	P30043	BLVRB_HUMAN	Homo sapiens	3	0.7154
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7153
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7148
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7145
Glycylpeptide N-tetradecanoyltransferase	A5K1A2	A5K1A2_PLAVS	Plasmodium vivax	3	0.7144
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7142
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7139
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7134
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7132
Transcriptional enhancer factor TEF-4	Q15562	TEAD2_HUMAN	Homo sapiens	3	0.7127
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7124
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7121
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7119
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7113
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7109
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7093
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.7093
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7091
Orotidine 5'-phosphate decarboxylase	O58462	PYRF_PYRHO	Pyrococcus horikoshii	3	0.7090
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7089
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7087
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7071
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7071
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	4	0.7069
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7057
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7054
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7053
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7051
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7049
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7044
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7041
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7038
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7037
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7035
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7033
Casein kinase I isoform delta	P48730	KC1D_HUMAN	Homo sapiens	3	0.7033
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	4	0.7032
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	2	0.7031
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7030
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7029
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7026
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7025
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7025
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7023
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7020
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7018
F420-dependent NADP reductase	O29370	FNO_ARCFU	Archaeoglobus fulgidus	4	0.7016
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7014
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7013
Putative secreted protein	C9Z6T8	C9Z6T8_STRSW	Streptomyces scabiei	4	0.7012
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7007
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7006
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7006
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7006

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