7-methoxyisochamanetin - Compound Card

7-methoxyisochamanetin

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7-methoxyisochamanetin

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles COc1cc2O[C@@H](CC(=O)c2c(c1Cc1ccccc1O)O)c1ccccc1
InChI InChI=1S/C23H20O5/c1-27-20-13-21-22(18(25)12-19(28-21)14-7-3-2-4-8-14)23(26)16(20)11-15-9-5-6-10-17(15)24/h2-10,13,19,24,26H,11-12H2,1H3/t19-/m0/s1
InChIKey CTWWMDVPBXRLBM-IBGZPJMESA-N
Formula C23H20O5
HBA 5
HBD 2
MW 376.41
Rotatable Bonds 4
TPSA 75.99
LogP 4.4
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 376.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cleistochlamys kirkii Annonaceae Plantae 1237197

Showing of synonyms

  • Nyandoro SS, Maeda G, et al. (2019). A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii. Molecules 2019, 24(15), 2746. [View] [PubMed]
Pubchem: 70698153
Chebi: 69689
Nmrshiftdb2: 60146403
Metabolights: MTBLC69689

No compound-protein relationship available.

Structure

SMILES: c1ccccc1Cc(c2)ccc(c23)OC(CC3=O)c4ccccc4

Level: 2

Mol. Weight: 376.41 g/mol

Structure

SMILES: c1ccccc1Cc(c2)ccc(c23)OCCC3=O

Level: 1

Mol. Weight: 376.41 g/mol

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 376.41 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 376.41 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 376.41 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.700
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.16

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.470
Plasma Protein Binding
94.85
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.690
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.730
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.000
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
5.740
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-12.910
Rat (Acute)
2.440
Rat (Chronic Oral)
2.540
Fathead Minnow
5.200
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
467.550
Hydration Free Energy
-6.610
Log(D) at pH=7.4
3.610
Log(P)
4.87
Log S
-6.04
Log(Vapor Pressure)
-9.52
Melting Point
148.3
pKa Acid
7.68
pKa Basic
5.77
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9534
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.9349
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9341
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.9331
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9235
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.9233
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9228
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9212
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.9197
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9170
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9087
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.9021
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8969
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8939
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8938
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8877
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8855
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8837
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8820
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8812
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8779
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8765
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8735
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8604
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8524
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8517
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8507
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8497
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8447
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8417
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8407
Heat shock cognate 71 kDa protein P11142 HSP7C_HUMAN Homo sapiens 3 0.8382
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8332
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8304
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.8299
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8284
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8282
Sepiapterin reductase P35270 SPRE_HUMAN Homo sapiens 3 0.8280
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8277
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8274
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8272
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8252
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8233
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8203
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 3 0.8187
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8181
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8174
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8172
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.8157
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8150
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 4 0.8144
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8138
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8121
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8117
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8107
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8092
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.8071
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8062
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8045
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8045
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8039
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8033
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8032
Probable nicotinate-nucleotide adenylyltransferase C3L5T6 NADD_BACAC Bacillus anthracis 3 0.8032
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8012
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8004
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7995
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.7985
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7979
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7944
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7939
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 3 0.7938
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7927
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7916
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7913
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7894
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7893
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.7889
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7886
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7885
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7882
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7875
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7840
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7836
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7835
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7834
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7773
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7771
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7767
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7764
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.7726
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7725
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7704
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7701
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7696
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 4 0.7688
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7684
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7664
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7662
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7650
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7642
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7632
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7629
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7608
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7603
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7595
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7595
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7592
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7580
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7579
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7570
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7562
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7560
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7551
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7549
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7549
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7535
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7530
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7505
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7502
Dihydroorotate dehydrogenase (quinone), mitochondrial Q63707 PYRD_RAT Rattus norvegicus 3 0.7496
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7470
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7469
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7465
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7454
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7447
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7443
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7439
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7436
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7426
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7416
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7406
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7403
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7400
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7390
A disintegrin and metalloproteinase with thrombospondin motifs 4 O75173 ATS4_HUMAN Homo sapiens 3 0.7380
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7370
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7367
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7365
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7355
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7354
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7351
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7351
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7342
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7336
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7336
N(2)-(2-carboxyethyl)arginine synthase Q9LCV9 CEAS_STRCL Streptomyces clavuligerus 3 0.7333
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7332
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7326
Aclacinomycin 10-hydroxylase RdmB Q54527 RDMB_STREF Streptomyces purpurascens 3 0.7324
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7323
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7322
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7320
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7320
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7314
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 4 0.7310
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7307
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7305
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7304
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7303
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7297
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7296
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7295
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7294
UDP-N-acetylenolpyruvoylglucosamine reductase P08373 MURB_ECOLI Escherichia coli 3 0.7289
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7289
Glutaminyl-peptide cyclotransferase Q16769 QPCT_HUMAN Homo sapiens 3 0.7287
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7286
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7284
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7284
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7270
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7270
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7265
Tissue factor P13726 TF_HUMAN Homo sapiens 3 0.7264
BDNF/NT-3 growth factors receptor Q16620 NTRK2_HUMAN Homo sapiens 4 0.7260
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7254
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7242
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7233
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7232
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7230
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7226
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7224
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7219
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7214
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7212
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7208
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7206
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7205
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7205
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7202
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7198
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7196
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7191
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7190
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7190
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7189
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7187
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7183
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7181
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7181
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7177
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 4 0.7173
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7173
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7171
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7167
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7166
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7163
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7163
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7162
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7155
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7145
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7134
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 4 0.7119
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7117
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7113
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7108
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7108
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7105
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7102
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7095
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7087
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7084
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7080
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7078
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7073
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7073
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7069
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7062
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7061
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7051
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7047
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7042
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7040
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7039
Glycylpeptide N-tetradecanoyltransferase Q9UVX3 NMT_ASPFU Aspergillus fumigatus 3 0.7038
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7036
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.7035
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.7033
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7031
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7029
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7023
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 4 0.7022
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7012
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7011
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7011
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7010

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