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2-methoxybenzyl benzoate

Family: Plantae - Annonaceae
Kingdom: Plantae
Class: Benzyl Ester

Canonical Smiles	COc1ccccc1COC(=O)c1ccccc1
InChI	InChI=1S/C15H14O3/c1-17-14-10-6-5-9-13(14)11-18-15(16)12-7-3-2-4-8-12/h2-10H,11H2,1H3
InChIKey	BZUHSQFJABFAHL-UHFFFAOYSA-N
Formula	C₁₅H₁₄O₃
HBA	3
HBD	0
MW	242.27
Rotatable Bonds	4
TPSA	35.53
LogP	3.05
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	18
Formal Charge	0
Fraction CSP3	0.13
Exact Mass	242.09
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Cleistochlamys kirkii	Annonaceae	Plantae	1237197

Showing of synonyms

Nyandoro SS, Maeda G, et al. (2019). A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii. Molecules 2019, 24(15), 2746. [View] [PubMed]

Pubchem: 3085295

Cas: 64421-25-6

Nmrshiftdb2: 60032552

Chembl: CHEMBL498647

Comptox: DTXSID50214675

Bindingdb: 50479171

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)OCc2ccccc2

Level: 1

Mol. Weight: 242.27 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 242.27 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp): -4.58
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.090
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.88

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.010
Plasma Protein Binding: 61.04
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 4.260
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.490
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.010
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.660
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.180
Rat (Acute): 1.700
Rat (Chronic Oral): 2.130
Fathead Minnow: 4.640
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 327.190
Hydration Free Energy: -6.150
Log(D) at pH=7.4: 4.020
Log(P): 3.84
Log S: -4.41
Log(Vapor Pressure): -3.85
Melting Point: 46.46
pKa Acid: 12.11
pKa Basic: -1.64

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9910
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9827
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9763
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9733
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9705
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.9652
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9473
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.9437
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.9375
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9361
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9322
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9320
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.9315
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9280
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.9238
Pyruvate kinase PKM	P14618	KPYM_HUMAN	Homo sapiens	3	0.9226
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9224
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9199
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9102
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.9092
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9084
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.9050
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9046
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9006
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8974
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.8893
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8709
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8654
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8603
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8600
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8572
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.8534
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8523
Isoliquiritigenin 2'-O-methyltransferase	P93324	CHOMT_MEDSA	Medicago sativa	3	0.8456
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8352
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.8307
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8260
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.8247
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8234
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8167
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8148
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8138
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8107
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.8100
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.8085
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.8063
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8059
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8057
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	3	0.8039
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.8021
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.8010
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	4	0.7982
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7977
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7964
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	2	0.7959
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7908
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7884
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7874
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7866
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7863
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7860
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7857
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7854
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7835
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7824
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7824
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7824
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7821
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	2	0.7818
Serine protease 1	P00760	TRY1_BOVIN	Bos taurus	3	0.7807
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	2	0.7806
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	2	0.7794
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7767
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7766
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7753
Probable flavin-dependent thymidylate synthase	O41156	THYX_PBCV1	Paramecium bursaria Chlorella virus 1	3	0.7752
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7726
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7719
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7715
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7703
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7692
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.7691
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7690
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7678
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7674
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7674
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7669
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7653
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7644
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7643
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	2	0.7643
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7636
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7635
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7627
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7611
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7605
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7600
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7600
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	2	0.7599
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7595
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7592
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7590
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7587
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7585
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7582
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7571
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7554
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	2	0.7549
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7545
Peroxisome proliferator-activated receptor alpha	Q07869	PPARA_HUMAN	Homo sapiens	2	0.7537
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7537
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7533
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	2	0.7533
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	2	0.7531
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7528
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	2	0.7526
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7520
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7516
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7515
Macrophage colony-stimulating factor 1 receptor	P07333	CSF1R_HUMAN	Homo sapiens	3	0.7502
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7497
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7493
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	3	0.7493
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7484
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7479
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7477
Cyclic GMP-AMP synthase	Q8C6L5	CGAS_MOUSE	Mus musculus	3	0.7475
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7473
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7471
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	2	0.7462
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7460
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7456
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7451
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7449
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7447
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7444
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	2	0.7444
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7439
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7439
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7423
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7422
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7422
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7417
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7417
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7415
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7415
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7406
Peroxisome proliferator-activated receptor delta	Q03181	PPARD_HUMAN	Homo sapiens	2	0.7392
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7391
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7388
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7387
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7387
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7387
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7385
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	2	0.7379
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7376
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7370
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7365
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7364
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7364
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7363
Endoplasmic reticulum aminopeptidase 2	Q6P179	ERAP2_HUMAN	Homo sapiens	2	0.7356
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7356
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7355
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7355
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7354
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7353
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7349
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	2	0.7345
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7343
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7340
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7335
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7333
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7333
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7332
Protein mono-ADP-ribosyltransferase PARP15	Q460N3	PAR15_HUMAN	Homo sapiens	3	0.7328
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7326
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7326
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7315
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7309
Neutrophil gelatinase-associated lipocalin	P80188	NGAL_HUMAN	Homo sapiens	2	0.7306
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7291
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7287
Alanine racemase	Q65YW7	Q65YW7_STRLA	Streptomyces lavendulae subsp. lavendulae	3	0.7281
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7275
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	2	0.7273
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7268
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7268
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7267
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7267
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7266
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7266
Cysteine desulfurase IscS 2	O29689	ISCS2_ARCFU	Archaeoglobus fulgidus	2	0.7266
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7261
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	2	0.7249
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7245
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7243
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7243
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7238
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7236
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7233
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	2	0.7232
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7230
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7228
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	2	0.7226
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7225
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7219
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7218
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7217
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7215
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7215
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7209
Poly [ADP-ribose] polymerase tankyrase-1	O95271	TNKS1_HUMAN	Homo sapiens	2	0.7209
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7206
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.7203
Inorganic pyrophosphatase	Q3JUV5	Q3JUV5_BURP1	Burkholderia pseudomallei	2	0.7199
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7197
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7193
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7193
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7190
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7189
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7189
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7185
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7185
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7184
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7183
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7181
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7180
Hut operon positive regulatory protein	P10943	HUTP_BACSU	Bacillus subtilis	2	0.7174
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7172
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	2	0.7171
Cellular retinoic acid-binding protein 2	P29373	RABP2_HUMAN	Homo sapiens	2	0.7171
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7170
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7168
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7166
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7163
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	2	0.7162
Beta-ketoacyl-[acyl-carrier-protein] synthase III	Q820T1	FABH_ENTFA	Enterococcus faecalis	2	0.7161
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7161
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7154
Tryptophan synthase beta chain 2	Q97TX6	TRPB2_SACS2	Saccharolobus solfataricus	2	0.7148
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	2	0.7144
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7141
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7136
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	2	0.7133
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7132
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7127
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7124
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7122
Cytochrome P450 2C9	P11712	CP2C9_HUMAN	Homo sapiens	2	0.7118
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7118
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7115
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7114
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7114
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7109
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7109
Cysteine desulfurase IscS 2	O29689	ISCS2_ARCFU	Archaeoglobus fulgidus	2	0.7109
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	2	0.7108
Calmodulin-domain protein kinase 1, putative	A3FQ16	A3FQ16_CRYPI	Cryptosporidium parvum	3	0.7103
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7102
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7100
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	2	0.7090
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7079
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7079
Botulinum neurotoxin type A	P0DPI0	BXA1_CLOBO	Clostridium botulinum	2	0.7077
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7074
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7070
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	2	0.7069
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	2	0.7066
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7065
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	2	0.7060
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7050
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	2	0.7045
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7044
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7042
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7033
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	2	0.7023
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7022
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	2	0.7017
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7016
Ephrin type-A receptor 3	P29320	EPHA3_HUMAN	Homo sapiens	3	0.7004
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7004
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7004

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