1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)propan-1-one - Compound Card

1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)propan-1-one

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1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)propan-1-one

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles COc1ccc(c(c1)O)C(=O)C(c1ccc(cc1)O)C
InChI InChI=1S/C16H16O4/c1-10(11-3-5-12(17)6-4-11)16(19)14-8-7-13(20-2)9-15(14)18/h3-10,17-18H,1-2H3
InChIKey ATKPVEWHCURUDQ-UHFFFAOYSA-N
Formula C16H16O4
HBA 4
HBD 2
MW 272.3
Rotatable Bonds 4
TPSA 66.76
LogP 3.09
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 272.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Monanthotaxis trichocarpa Annonaceae Plantae 1202425

Showing of synonyms

  • Maeda G, van der Wal J, et al. (2020). Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa. Journal of natural products,2020, 83(2), 210-215. [View] [PubMed]
Pubchem: 10635893

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)Cc2ccccc2

Level: 1

Mol. Weight: 272.3 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 272.3 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.54
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.680
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.06

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.120
Plasma Protein Binding
45.72
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.530
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.050
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.310
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.980
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.500
Rat (Acute)
1.830
Rat (Chronic Oral)
2.670
Fathead Minnow
4.440
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
377.810
Hydration Free Energy
-10.630
Log(D) at pH=7.4
3.310
Log(P)
3.57
Log S
-5.2
Log(Vapor Pressure)
-6.42
Melting Point
99.54
pKa Acid
7.53
pKa Basic
6.62
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9807
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9747
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9724
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9636
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9570
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9542
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9536
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9523
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9515
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9515
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9475
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9460
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9458
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.9453
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9447
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9436
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9428
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9418
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9415
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9390
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9387
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9385
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9375
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9369
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9365
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9362
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9326
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9290
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.9286
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9284
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.9282
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9281
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9274
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9253
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9252
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9251
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.9237
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9233
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9231
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9225
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9218
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9214
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9214
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9211
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9211
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9200
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.9193
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.9192
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9184
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9177
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9140
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9138
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9125
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9119
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9106
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9089
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9083
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.9036
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.9027
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9023
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9021
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9009
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8986
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8973
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8969
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8965
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8965
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8964
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8957
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8948
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8946
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8943
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8938
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8936
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8931
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8914
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8913
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8900
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8897
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8895
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8888
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8888
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8881
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.8872
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8868
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8865
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8862
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8852
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8839
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8834
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8829
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8814
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8814
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8811
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8790
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8786
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8778
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8776
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8772
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8767
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8763
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8759
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.8757
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8754
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8748
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8745
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8734
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8731
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8717
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8700
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8697
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.8693
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8689
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8686
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8685
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8681
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8663
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8660
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8658
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8646
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8645
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8619
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8614
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8614
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8605
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8595
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8594
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8589
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8578
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8577
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8570
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8569
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8556
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8555
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8542
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8537
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8532
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8523
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 4 0.8517
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8511
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8511
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8510
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8507
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8498
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8495
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8475
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8474
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8471
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8466
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8464
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8453
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.8439
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8437
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.8437
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.8415
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8412
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.8409
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8408
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.8407
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.8402
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8395
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8389
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 4 0.8384
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8384
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase O58523 TYW2_PYRHO Pyrococcus horikoshii 3 0.8384
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8381
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8379
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8362
Universal stress protein family protein, putative A0QYW6 A0QYW6_MYCS2 Mycolicibacterium smegmatis155) 4 0.8362
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8354
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8351
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8347
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8343
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8335
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8329
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8328
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8324
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8323
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8310
Coniferyl alcohol 9-O-methyltransferase A6XNE6 A6XNE6_9ROSI Linum nodiflorum 3 0.8309
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8302
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8297
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8284
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8281
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8274
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8271
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8264
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8257
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.8235
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8228
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.8225
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8220
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8218
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8206
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8201
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8195
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8191
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.8187
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8177
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8168
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8151
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8147
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8145
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8144
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8143
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8131
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8127
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.8124
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8124
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8123
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8112
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8108
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8099
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8095
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8089
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8087
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8084
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8084
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.8084
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8082
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.8079
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8078
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8070
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8066
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8063
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8055
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8050
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8030
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8025
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8017
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8014
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.8013
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8012
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8010
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8006
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8006
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7991
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7977
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7973
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.7970
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7969
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7966
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7962
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.7954
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7953
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7951
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7949
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7940
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7939
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7939
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7936
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7929
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7927
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7926
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7898
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7896
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7894
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7894
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7893
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7891
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7888
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7884
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7878
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7876
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7876
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7874
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7855
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7844
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7842
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7842
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7839
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7835
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7830
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7826
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7823
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 4 0.7816
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7814
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7812
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7808
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7808
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7804
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7804
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7801
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7797
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7789
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7787
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7787
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7781
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7780
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7779
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7776
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7772
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7772
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7768
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7757
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7753
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7753
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7750
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7748
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7744
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7743
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7742
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7738
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7737
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7732
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7729
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7727
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7724
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7720
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7717
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7715
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7698
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7698
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7696
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7696
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7696
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7693
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 3 0.7692
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7689
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7689
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7688
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7686
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7684
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7683
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7680
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7675
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7674
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7672
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7672
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7669
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7667
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7666
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7665
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7665
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7664
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7663
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7661
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7660
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7653
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7651
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7646
Inorganic pyrophosphatase Q3JUV5 Q3JUV5_BURP1 Burkholderia pseudomallei 3 0.7642
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7639
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7637
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7631
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7629
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7625
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7625
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7624
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7624
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7622
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7619
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7618
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7616
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7611
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7609
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7608
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7606
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7606
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7604
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7603
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7599
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 3 0.7598
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.7597
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7595
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7594
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7593
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7591
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7590
Probable nicotinate-nucleotide adenylyltransferase Q9HX21 NADD_PSEAE Pseudomonas aeruginosa 3 0.7590
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7585
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7584
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7583
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7581
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7574
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7574
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7571
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7569
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7565
5'-methylthioadenosine nucleosidase Q9T0I8 MTN1_ARATH Arabidopsis thaliana 3 0.7561
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7560
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7557
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7552
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7552
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7549
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7549
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7547
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7542
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7542
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7540
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7531
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7529
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7522
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7521
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7521
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7518
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7518
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7518
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7511
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7504
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7503
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7501
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7500
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7499
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7499
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7495
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7495
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7489
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7487
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7484
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7484
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7482
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7479
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7478
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7475
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7474
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7470
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7469
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7468
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 4 0.7467
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7465
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7465
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7462
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7462
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7460
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7458
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7458
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7457
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7457
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7457
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7456
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7454
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7454
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7450
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7450
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 4 0.7443
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7443
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7443
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7441
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7438
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7438
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7432
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7431
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7430
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7428
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7425
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7422
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7418
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 4 0.7417
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7416
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7415
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7414
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 3 0.7413
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7413
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7411
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7405
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7401
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7399
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7396
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7396
Dimethylsulfonioproprionate demethylase DmdA Q4FP21 DMDA_PELUB Pelagibacter ubique 4 0.7396
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7393
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7393
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7386
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7386
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7386
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7384
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7383
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7382
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7382
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7379
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7374
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7374
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7369
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7368
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7367
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7367
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7365
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7365
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7365
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7364
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7362
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7361
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7357
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7354
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7351
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7347
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7346
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7345
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7344
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7341
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7341
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7338
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7333
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 2 0.7331
Pyruvate oxidase P37063 POXB_LACPL Lactiplantibacillus plantarum 3 0.7330
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7329
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7329
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7328
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7327
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7319
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7317
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7316
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7313
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7310
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7304
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7303
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7301
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7300
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7295
Phytohormone-binding protein G7J032 PHBP_MEDTR Medicago truncatula 4 0.7293
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7291
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7288
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7287
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7286
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7285
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7284
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7283
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7281
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7281
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7276
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7276
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7273
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7272
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7272
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7270
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7268
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7266
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7266
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7265
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7263
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7262
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7262
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7261
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7259
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7259
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7255
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7253
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7252
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7252
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7251
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7249
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7246
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7245
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7245
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7241
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7238
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7237
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7237
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7237
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7234
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7232
Tubulin alpha-1B chain Q2XVP4 TBA1B_PIG Sus scrofa 3 0.7232
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7226
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7224
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7223
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7223
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7222
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7218
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7212
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7210
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7208
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7208
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7205
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7203
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7203
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7200
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7200
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7199
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7199
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7197
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7197
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7196
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7195
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7195
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7193
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7192
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7191
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7190
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7190
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7189
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7187
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7186
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7185
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7185
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7180
7-methylguanosine phosphate-specific 5'-nucleotidase Q9W197 5NT3B_DROME Drosophila melanogaster 3 0.7180
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7180
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 3 0.7179
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7177
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7177
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 4 0.7177
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7175
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7173
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7173
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 3 0.7171
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 4 0.7169
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7169
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7167
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7164
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7163
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7163
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7162
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7162
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7162
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7160
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7156
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7155
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7154
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7154
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7150
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7145
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7142
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7142
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7140
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 4 0.7137
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7137
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7134
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7133
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7131
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7130
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7129
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7126
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7126
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7119
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7117
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7110
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7110
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7109
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7109
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7109
Genome polyprotein Q9WLZ5 Q9WLZ5_9FLAV dengue virus type 2 3 0.7108
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7107
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7102
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7102
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7101
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7101
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7096
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7096
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7095
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7095
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7095
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7093
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7093
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7091
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7089
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7086
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7084
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7083
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7082
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7081
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7080
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7079
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7077
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7077
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7075
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 3 0.7074
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7074
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7073
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7073
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7073
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7072
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7070
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7070
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7069
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7067
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7066
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7064
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7062
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7062
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7059
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7059
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7058
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7055
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7054
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7052
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7052
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7051
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7051
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7050
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7050
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7045
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7045
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7045
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7043
Pyruvate decarboxylase isozyme 1 P06169 PDC1_YEAST Saccharomyces cerevisiae 3 0.7042
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7041
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7039
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7038
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7038
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7037
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7035
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7035
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7035
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7034
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7032
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7032
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7029
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7028
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.7024
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7024
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7023
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 3 0.7022
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7021
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7019
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7018
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7018
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7018
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7017
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7013
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7012
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7008
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7007
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7007
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7006
Indole-3-pyruvate decarboxylase P23234 DCIP_ENTCL Enterobacter cloacae 3 0.7005
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7003
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7002
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7002
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7002
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7001

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