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3′′-hydroxyisochamanetin

Family: Plantae - Annonaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavanone

Canonical Smiles	Oc1cc2O[C@@H](CC(=O)c2c(c1Cc1cccc(c1O)O)O)c1ccccc1
InChI	InChI=1S/C22H18O6/c23-15-8-4-7-13(21(15)26)9-14-16(24)10-19-20(22(14)27)17(25)11-18(28-19)12-5-2-1-3-6-12/h1-8,10,18,23-24,26-27H,9,11H2/t18-/m0/s1
InChIKey	FMCBIXROZWHXRU-SFHVURJKSA-N
Formula	C₂₂H₁₈O₆
HBA	6
HBD	4
MW	378.38
Rotatable Bonds	3
TPSA	107.22
LogP	3.81
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	28
Formal Charge	0
Fraction CSP3	0.14
Exact Mass	378.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Sphaerocoryne gracilis	Annonaceae	Plantae	489348

Showing of synonyms

Maeda G, Munissi JJE, et al. (2020). A Meroisoprenoid, Heptenolides, and C‐Benzylated Flavonoids from Sphaerocoryne gracilis ssp. Gracilis. Journal of natural products,2020, 83(2), 316-322. [View] [PubMed]

Pubchem: 38360853

Chembl: CHEMBL4643132

No compound-protein relationship available.

SMILES: c1ccccc1Cc(c2)ccc(c23)OC(CC3=O)c4ccccc4

Level: 2

Mol. Weight: 378.38 g/mol

SMILES: c1ccccc1Cc(c2)ccc(c23)OCCC3=O

Level: 1

Mol. Weight: 378.38 g/mol

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 378.38 g/mol

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 378.38 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 378.38 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.74
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.000
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -0.14

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.040
Plasma Protein Binding: 102.51
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.070
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.620
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.440
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 4.520
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -10.280
Rat (Acute): 2.450
Rat (Chronic Oral): 3.080
Fathead Minnow: 4.720
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 512.650
Hydration Free Energy: -7.450
Log(D) at pH=7.4: 2.600
Log(P): 4.16
Log S: -5.23
Log(Vapor Pressure): -10.18
Melting Point: 203.35
pKa Acid: 4.97
pKa Basic: 7.99

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9380
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	3	0.9333
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9189
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9173
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9097
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.9075
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.9055
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.9036
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8993
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8955
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8941
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8910
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8871
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8809
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8783
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8777
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.8753
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8734
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8723
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8721
Neutrophil gelatinase-associated lipocalin	P80188	NGAL_HUMAN	Homo sapiens	3	0.8680
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8671
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8651
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8624
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8610
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.8580
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8522
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.8492
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8447
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8431
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8385
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8334
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8318
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8301
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.8284
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8264
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8259
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8256
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8254
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	3	0.8234
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8194
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8193
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	4	0.8187
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8175
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8169
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8159
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8153
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8150
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.8129
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8115
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.8094
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	4	0.8054
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8044
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.8029
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8004
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7987
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.7979
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.7971
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7966
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7943
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.7933
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7898
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7879
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7867
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7778
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7768
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7752
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7749
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7749
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7747
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7723
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.7714
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7706
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7686
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7679
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7667
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7667
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	4	0.7652
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7641
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7635
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7632
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7609
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7608
Sepiapterin reductase	P35270	SPRE_HUMAN	Homo sapiens	3	0.7606
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7602
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7595
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7588
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7587
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.7584
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.7576
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.7574
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7566
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7544
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7531
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7525
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.7524
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	3	0.7516
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7510
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7506
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7503
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7499
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7482
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7482
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.7477
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7465
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7462
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7459
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7448
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	4	0.7440
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7435
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7430
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7425
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7406
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7396
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7394
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7391
Nucleoside diphosphate kinase	O58429	NDK_PYRHO	Pyrococcus horikoshii	3	0.7388
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	Q6NVY1	HIBCH_HUMAN	Homo sapiens	3	0.7386
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7385
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7334
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.7325
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7322
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7322
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7319
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7316
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7309
Serine/threonine-protein kinase VRK1	Q99986	VRK1_HUMAN	Homo sapiens	3	0.7303
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7298
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7288
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7277
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7269
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	2	0.7269
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7267
C-1-tetrahydrofolate synthase, cytoplasmic	P11586	C1TC_HUMAN	Homo sapiens	3	0.7249
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7247
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7247
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7239
Type II methyltransferase M.RsrI	P14751	MTR1_RHOSH	Cereibacter sphaeroides	3	0.7227
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7224
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7216
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7207
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7205
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7205
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7202
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7201
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7201
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	4	0.7191
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7188
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7187
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7186
Aspartate carbamoyltransferase catalytic subunit	P0A786	PYRB_ECOLI	Escherichia coli	2	0.7180
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7158
Exotoxin A	P11439	TOXA_PSEAE	Pseudomonas aeruginosa	4	0.7145
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.7140
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein	Q5SHN1	Q5SHN1_THET8	Thermus thermophilus	3	0.7134
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7133
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7130
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	3	0.7119
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7116
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7113
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7112
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.7106
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7083
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7079
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.7079
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7065
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7062
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	3	0.7061
E3 ubiquitin-protein ligase RNF31	Q96EP0	RNF31_HUMAN	Homo sapiens	3	0.7059
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.7057
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7049
Metallo-beta-lactamase type 2	P52699	BLAB_SERMA	Serratia marcescens	3	0.7046
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7040
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7039
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7037
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7034
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q63707	PYRD_RAT	Rattus norvegicus	3	0.7022
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7009
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7008
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7002

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