2,3-dehydro-3′′-hydroxychamanetin - Compound Card

2,3-dehydro-3′′-hydroxychamanetin

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2,3-dehydro-3′′-hydroxychamanetin

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles Oc1c(O)cccc1Cc1c(O)cc(c2c1oc(cc2=O)c1ccccc1)O
InChI InChI=1S/C22H16O6/c23-15-8-4-7-13(21(15)27)9-14-16(24)10-17(25)20-18(26)11-19(28-22(14)20)12-5-2-1-3-6-12/h1-8,10-11,23-25,27H,9H2
InChIKey MAFSHIJISCSKKD-UHFFFAOYSA-N
Formula C22H16O6
HBA 6
HBD 4
MW 376.36
Rotatable Bonds 3
TPSA 111.13
LogP 3.87
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.05
Exact Mass 376.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Sphaerocoryne gracilis Annonaceae Plantae 489348

Showing of synonyms

  • Maeda G, Munissi JJE, et al. (2020). A Meroisoprenoid, Heptenolides, and C‐Benzylated Flavonoids from Sphaerocoryne gracilis ssp. Gracilis. Journal of natural products,2020, 83(2), 316-322. [View] [PubMed]
Pubchem: 38361344

No compound-protein relationship available.

Structure

SMILES: c1ccccc1Cc(ccc2)c(c23)oc(cc3=O)-c4ccccc4

Level: 2

Mol. Weight: 376.36 g/mol

Structure

SMILES: c1ccccc1Cc(ccc2)c(c23)occc3=O

Level: 1

Mol. Weight: 376.36 g/mol

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 376.36 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 376.36 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 376.36 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.4
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.12
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
1.04

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.1
Plasma Protein Binding
103.03
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.5
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.26
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.56
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.2
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-9.32
Rat (Acute)
2.41
Rat (Chronic Oral)
3.09
Fathead Minnow
5.39
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
548.3
Hydration Free Energy
-8.11
Log(D) at pH=7.4
3.04
Log(P)
4.35
Log S
-5.45
Log(Vapor Pressure)
-10.8
Melting Point
264.01
pKa Acid
5.29
pKa Basic
7.27
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.9735
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9671
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9499
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9318
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9311
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.9292
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9215
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9198
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9182
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9165
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9165
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9152
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9119
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 3 0.9066
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 3 0.9039
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.9002
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8995
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.8977
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 3 0.8921
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8915
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8876
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8796
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8764
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8747
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8680
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8629
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8608
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8591
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8584
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.8556
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 3 0.8545
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8539
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8517
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8504
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8439
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8435
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8393
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8388
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8371
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8357
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8347
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8347
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8330
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8296
UDP-N-acetylglucosamine 1-carboxyvinyltransferase P33038 MURA_ENTCC Enterobacter cloacae subsp. cloacae 3 0.8291
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8279
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8279
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8276
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8275
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8255
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8229
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8221
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.8199
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8164
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8147
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8098
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8089
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8083
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8058
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8054
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8050
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8002
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7992
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7992
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7979
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7979
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7975
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7943
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7937
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7914
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7894
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 4 0.7882
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7879
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7877
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7849
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7837
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7831
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7813
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7790
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7782
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.7775
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7765
Tissue factor P13726 TF_HUMAN Homo sapiens 3 0.7761
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7760
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7756
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7730
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7703
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7702
Mitogen-activated protein kinase 14 P47811 MK14_MOUSE Mus musculus 4 0.7696
Geranylgeranyl transferase type-2 subunit alpha Q08602 PGTA_RAT Rattus norvegicus 3 0.7693
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7691
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7687
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7674
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7656
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7646
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 4 0.7643
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.7643
Bromodomain-containing protein 9 Q9H8M2 BRD9_HUMAN Homo sapiens 3 0.7642
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7637
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7636
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7634
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 4 0.7617
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7616
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7608
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7604
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7603
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7601
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7601
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7591
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7591
M17 leucyl aminopeptidase Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3 0.7572
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7571
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 4 0.7570
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.7567
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7555
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7536
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7531
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7523
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7510
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 4 0.7509
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7506
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7498
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7494
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7480
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7473
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7464
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7455
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7439
Albumin P35747 ALBU_HORSE Equus caballus 3 0.7436
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7432
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7421
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7400
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7399
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7398
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7395
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7395
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7392
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7392
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7391
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7383
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7380
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7380
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7366
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7361
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7347
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7344
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7340
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 4 0.7337
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7302
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7290
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7285
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7275
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 3 0.7262
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7255
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7252
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7252
Cytochrome P450 107B1 A0R5U2 A0R5U2_MYCS2 Mycolicibacterium smegmatis155) 3 0.7248
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7244
Genome polyprotein O93077 O93077_9HEPC Hepacivirus hominis 4 0.7237
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7230
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7224
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7224
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7222
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7209
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7201
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7200
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7198
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7198
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7178
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 4 0.7177
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7159
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7156
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7155
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7153
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7153
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7142
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7126
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7126
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7125
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7124
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7115
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7109
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7109
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7107
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7104
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7104
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7100
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.7097
Capsid scaffolding protein P88911 P88911_HHV8 Human herpesvirus 8 type M 3 0.7089
Probable nicotinate-nucleotide adenylyltransferase Q9HX21 NADD_PSEAE Pseudomonas aeruginosa 3 0.7087
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7086
Mitogen-activated protein kinase 14 P47811 MK14_MOUSE Mus musculus 4 0.7084
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7078
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7077
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7073
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7067
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7062
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7060
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7057
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7053
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7050
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7050
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7048
RNA-directed RNA polymerase lambda-3 P0CK31 RDRP_REOVD Reovirus type 3 3 0.7037
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7031
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7028
Cytosol aminopeptidase P00727 AMPL_BOVIN Bos taurus 2 0.7025
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7020
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7004

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