3-methoxybenzyl benzoate - Compound Card

3-methoxybenzyl benzoate

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3-methoxybenzyl benzoate

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Phenolic Ester
Canonical Smiles COc1cccc(c1)COC(=O)c1ccccc1
InChI InChI=1S/C15H14O3/c1-17-14-9-5-6-12(10-14)11-18-15(16)13-7-3-2-4-8-13/h2-10H,11H2,1H3
InChIKey NCAWHAOZFKQDFK-UHFFFAOYSA-N
Formula C15H14O3
HBA 3
HBD 0
MW 242.27
Rotatable Bonds 4
TPSA 35.53
LogP 3.05
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 242.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Uvaria pandensis Annonaceae Plantae 673193

Showing of synonyms

  • Maeda G, Gilissen PJ, et al. (2021). Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis. Journal of natural products,2021, 84(12), 3080-3089. [View] [PubMed]
Pubchem: 12033230
Bindingdb: 50479183

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)OCc2ccccc2

Level: 1

Mol. Weight: 242.27 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 242.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.64
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.140
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.92

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.920
Plasma Protein Binding
67.58
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.290
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.500
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.980
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.850
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.280
Rat (Acute)
1.690
Rat (Chronic Oral)
2.130
Fathead Minnow
4.620
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
333.590
Hydration Free Energy
-6.190
Log(D) at pH=7.4
4.410
Log(P)
3.89
Log S
-4.63
Log(Vapor Pressure)
-4.07
Melting Point
27.13
pKa Acid
12.26
pKa Basic
-1.8
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9907
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9850
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9749
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9738
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9735
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9581
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.9579
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9469
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9432
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.9400
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9397
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.9378
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9369
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9360
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9225
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9224
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.9204
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9134
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9120
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9107
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9087
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9080
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9069
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9065
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9039
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9036
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9034
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9010
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8983
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8724
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8715
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8693
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8691
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8646
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8619
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8502
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8461
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8456
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8435
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.8349
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8347
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8331
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8285
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8258
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8251
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8234
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.8195
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8184
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8150
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8120
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8104
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.8084
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.8077
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8075
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8027
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8020
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7955
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7919
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7888
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7876
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7860
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7823
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7818
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7810
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7810
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7807
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7791
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7780
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7778
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7777
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7771
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7769
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7747
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7735
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7734
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7726
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7718
Serine protease 1 P00760 TRY1_BOVIN Bos taurus 3 0.7711
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7672
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 2 0.7667
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7650
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7643
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7643
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7640
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7634
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7630
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7627
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7620
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7619
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7616
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7611
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7603
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7602
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7599
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7597
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7595
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7593
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7587
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7582
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7582
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7581
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7574
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7552
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7549
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7547
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7544
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7536
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7535
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7535
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7533
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7530
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7526
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7521
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7518
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7514
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7512
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7512
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7511
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7509
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7502
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7495
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7482
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7464
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7461
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7455
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7455
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7453
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7449
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7447
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7444
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7442
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7433
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7432
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7430
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7426
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7426
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7421
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7414
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7413
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7407
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7399
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7398
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7394
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 4 0.7392
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7387
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7384
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7380
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7378
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7377
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7377
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7376
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 3 0.7368
Peroxisome proliferator-activated receptor delta Q03181 PPARD_HUMAN Homo sapiens 2 0.7368
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7365
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7356
Probable flavin-dependent thymidylate synthase O41156 THYX_PBCV1 Paramecium bursaria Chlorella virus 1 3 0.7347
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7341
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7335
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7335
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7329
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7327
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7324
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7322
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7321
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7321
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7319
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7313
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7306
Endoglycoceramidase II O33853 O33853_RHOSO Rhodococcus sp 3 0.7305
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7305
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7295
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7294
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7284
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7283
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7281
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7276
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7273
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7263
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7257
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7257
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7253
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 2 0.7252
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7252
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7250
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7248
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7243
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7242
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7236
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7232
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7230
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7230
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7225
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7212
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7209
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7208
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7202
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7196
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7191
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7188
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 2 0.7180
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7179
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7172
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7169
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7159
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7153
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7149
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7146
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7139
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7137
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7134
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7130
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 2 0.7128
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 2 0.7127
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7121
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7120
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7119
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7117
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7117
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7115
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7108
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7108
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7101
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7097
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7096
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7090
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 3 0.7085
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7085
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7082
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7080
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7073
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7072
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7071
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7070
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7067
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7064
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7060
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7049
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7049
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7048
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7046
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7037
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7037
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7025
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7024
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7016
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7015
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7011
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7011
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7010
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7009
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7008
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7007
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7005
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7002
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 2 0.7001

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