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Higenamine

Family: Plantae - Aristolochiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Hydroxybenzylisoquinoline

Canonical Smiles	Oc1ccc(cc1)CC1NCCc2c1cc(O)c(c2)O
InChI	InChI=1S/C16H17NO3/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14/h1-4,8-9,14,17-20H,5-7H2
InChIKey	WZRCQWQRFZITDX-UHFFFAOYSA-N
Formula	C₁₆H₁₇NO₃
HBA	4
HBD	4
MW	271.32
Rotatable Bonds	2
TPSA	72.72
LogP	2.23
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	20
Formal Charge	0
Fraction CSP3	0.25
Exact Mass	271.12
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Aristolochia brasiliensis	Aristolochiaceae	Plantae	171879

Showing of synonyms

Erasto P, Omolo J, et al. (2018). Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural products and bioprospecting,2018, 8(1), 63-69. [View] [PubMed]

Pubchem: 114840

Cas: 5843-65-2

Gnps: CCMSLIB00006517435

Kegg Ligand: C06346

Chebi: 18418

Nmrshiftdb2: 60025411

Metabolights: MTBLC18418

Chembl: CHEMBL19344

Drugbank: DB12779

CPRiL: 56233

SMILES: c1ccccc1CC2NCCc(c23)cccc3

Level: 1

Mol. Weight: 271.32 g/mol

SMILES: C1CNCc(c12)cccc2

Level: 0

Mol. Weight: 271.32 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 271.32 g/mol

Antimycobacterial

Absorption

Caco-2 (logPapp): -5.29
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.880
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.2

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.320
Plasma Protein Binding: 29.93
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 10.940
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.180
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.420
Liver Injury II: Safe
hERG Blockers: Toxic
Daphnia Maga: 5.160
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.600
Rat (Acute): 2.290
Rat (Chronic Oral): 2.600
Fathead Minnow: 4.080
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 401.920
Hydration Free Energy: -11.330
Log(D) at pH=7.4: 1.410
Log(P): 1.13
Log S: -1.54
Log(Vapor Pressure): -8.52
Melting Point: 214.16
pKa Acid: 9.76
pKa Basic: 8.93

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.9571
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9571
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.9279
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9175
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9149
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9106
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9044
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8983
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8903
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8891
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8869
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8833
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8818
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8811
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8799
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8789
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8788
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8773
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8738
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8651
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8626
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8612
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8608
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8600
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8569
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8561
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8529
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8521
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8507
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.8491
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8487
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.8484
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8472
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8459
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8451
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8392
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8390
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8339
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.8326
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8310
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8303
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8294
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8285
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8256
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8247
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8237
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8228
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.8219
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.8201
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8189
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8164
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	4	0.8163
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8159
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8155
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8154
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.8153
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.8150
Mannosylglycerate synthase	D0MI02	D0MI02_RHOM4	Rhodothermus marinus	4	0.8149
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.8140
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8120
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8104
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8092
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8088
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.8062
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.8060
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8057
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8056
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8036
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.8027
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8016
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8012
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8003
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7990
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7985
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7965
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7953
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7923
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	4	0.7919
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7909
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7832
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	5	0.7829
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7808
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7805
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7798
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7789
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7783
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.7769
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7757
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7740
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7731
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7726
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	4	0.7725
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7722
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7714
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7709
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7692
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7690
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	4	0.7689
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7685
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7680
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7670
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7663
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7661
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7661
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7657
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	3	0.7652
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7624
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7620
Leucine--tRNA ligase	P07813	SYL_ECOLI	Escherichia coli	3	0.7612
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7609
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7581
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7567
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7543
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7541
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7517
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7498
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7494
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7465
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7457
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7443
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7440
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7431
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7428
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7417
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7417
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7417
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7408
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7407
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7407
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.7407
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7401
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7397
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7393
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7391
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7368
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7366
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7360
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7360
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	3	0.7349
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7346
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7334
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7332
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7332
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7323
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7314
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7311
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7310
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7308
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.7296
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7295
Glutathione S-transferase	Q8ILQ7	GST_PLAFA	Plasmodium falciparum	3	0.7292
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7291
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7289
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7288
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7285
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7284
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7281
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7278
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7277
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7274
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7271
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7271
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7271
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7263
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7262
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7258
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7256
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7256
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7254
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7252
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7248
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7240
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein	Q5SHN1	Q5SHN1_THET8	Thermus thermophilus	3	0.7239
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7238
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	2	0.7231
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7229
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7219
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7217
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7209
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7206
Dodecin	Q5SIE3	DODEC_THET8	Thermus thermophilus	4	0.7201
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7201
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	3	0.7195
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7183
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7169
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7161
Isoflavone 4'-O-methyltransferase	Q29U70	I4OMT_MEDTR	Medicago truncatula	3	0.7158
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	4	0.7157
Poly [ADP-ribose] polymerase tankyrase-1	O95271	TNKS1_HUMAN	Homo sapiens	3	0.7156
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.7149
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7134
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7134
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7133
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7130
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7128
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7117
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	3	0.7104
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7102
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7101
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7100
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7097
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7094
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7090
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7088
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7088
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7084
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7083
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7074
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	3	0.7069
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7064
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7064
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7060
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7060
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7059
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7053
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7047
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7047
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7045
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7045
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7044
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7040
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.7036
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7033
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7032
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q3JRA0	ISPF_BURP1	Burkholderia pseudomallei	3	0.7028
Riboflavin biosynthesis protein	Q9WZW1	Q9WZW1_THEMA	Thermotoga maritima	4	0.7026
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7026
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7025
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7021
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7020
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7015
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7015
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	3	0.7006
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7005
Methionine adenosyltransferase 2 subunit beta	Q9NZL9	MAT2B_HUMAN	Homo sapiens	4	0.7003
Ephrin type-A receptor 2	P29317	EPHA2_HUMAN	Homo sapiens	3	0.7002
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7000

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