4-hydroxyderricin - Compound Card

4-hydroxyderricin

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4-hydroxyderricin

Structure
Zoomed Structure
  • Family: Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Chalcone
Canonical Smiles COc1ccc(c(c1CC=C(C)C)O)C(=O)/C=C/c1ccc(cc1)O
InChI InChI=1S/C21H22O4/c1-14(2)4-10-18-20(25-3)13-11-17(21(18)24)19(23)12-7-15-5-8-16(22)9-6-15/h4-9,11-13,22,24H,10H2,1-3H3/b12-7+
InChIKey XDKYBPGIBVMHHB-KPKJPENVSA-N
Formula C21H22O4
HBA 4
HBD 2
MW 338.4
Rotatable Bonds 6
TPSA 66.76
LogP 4.51
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 338.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Millettia dura Leguminosae/Fabaceae Plantae 62119

Showing of synonyms

  • Buyinza D, Chalo DM, et al. (2020). Flavonoids and Isoflavonoids of Millettia dura and Millettia ferruginea: Phytochemical review and chemotaxonomic values. Biochemical Systematics and Ecology, 2020, 91, 104053. [View]
Pubchem: 6438503
Chebi: 185630
Nmrshiftdb2: 60062121
Bindingdb: 50352809
CPRiL: 65557
Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 208.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.61
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.580
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.15

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.040
Plasma Protein Binding
60.8
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.460
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.220
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.900
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.110
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.570
Rat (Acute)
1.830
Rat (Chronic Oral)
2.900
Fathead Minnow
5.220
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
433.300
Hydration Free Energy
-10.030
Log(D) at pH=7.4
4.100
Log(P)
5.45
Log S
-6.61
Log(Vapor Pressure)
-7.37
Melting Point
141.05
pKa Acid
8.84
pKa Basic
6.37
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9456
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9431
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9393
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.9344
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9267
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.9242
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9177
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9153
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.9125
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.9052
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9044
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9017
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8962
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8954
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8915
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8883
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8764
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8748
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8720
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8717
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8618
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8581
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8537
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8512
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8368
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8337
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8333
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8319
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8305
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8289
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8279
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 4 0.8247
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8226
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8226
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8169
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8151
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 5 0.8149
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.8144
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8144
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8135
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8110
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 4 0.8093
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8062
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8040
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8031
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8016
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8012
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7995
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7983
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7957
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7930
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7929
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7914
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7896
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7877
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7870
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7853
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7814
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7741
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7732
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7719
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7707
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7706
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7675
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7662
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7638
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7637
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7637
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7621
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7598
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7581
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7577
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7572
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7569
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7565
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7564
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7557
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7545
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7541
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7538
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7533
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7531
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7512
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7504
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7488
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7486
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7477
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7462
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7461
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7455
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7450
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7447
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7442
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7440
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7438
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7435
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7429
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7424
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7410
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7397
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7396
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7388
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7387
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7379
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7378
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7361
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7347
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7340
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7327
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7325
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 4 0.7324
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7324
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7321
Serine/threonine-protein kinase B-raf P15056 BRAF_HUMAN Homo sapiens 3 0.7310
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7300
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7296
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7294
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7294
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7289
Gag-Pol polyprotein P04587 POL_HV1B5 Human immunodeficiency virus type 1 group M subtype B 4 0.7284
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7283
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7278
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7278
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7273
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7269
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7268
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7265
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7263
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7260
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7257
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7257
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7257
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7246
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7236
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7234
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7224
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7222
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7222
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7216
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7214
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7213
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7204
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7203
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7202
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7200
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7199
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7197
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7187
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7171
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7170
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7168
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7164
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7151
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7149
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7145
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.7141
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7134
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7131
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7128
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7123
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7121
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7118
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7118
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7116
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7115
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7111
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7106
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7105
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7102
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7102
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7099
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7094
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7087
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7084
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7076
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7064
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7062
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7060
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7059
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7057
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7055
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7053
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7040
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7039
Putative pteridine reductase 2 Q8I814 Q8I814_TRYCR Trypanosoma cruzi 4 0.7033
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7033
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7030
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7025
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7024
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7023
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7022
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 3 0.7021
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7021
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7019
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7015
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7015
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7010
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7008
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7005

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