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Dihydrousambarensine

Family: Plantae - Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indole Alkaloid

Canonical Smiles	C/C=C/1\CN2CCC3C([C@@H]2C[C@@H]1CC1=NCCc2c1[nH]c1c2cccc1)Nc1c3cccc1
InChI	InChI=1S/C29H32N4/c1-2-18-17-33-14-12-23-21-8-4-6-10-25(21)32-29(23)27(33)16-19(18)15-26-28-22(11-13-30-26)20-7-3-5-9-24(20)31-28/h2-10,19,23,27,29,31-32H,11-17H2,1H3/b18-2+/t19-,23?,27-,29?/m0/s1
InChIKey	JBQRORTXNDQJOM-AGDKNOKHSA-N
Formula	C₂₉H₃₂N₄
HBA	3
HBD	2
MW	436.6
Rotatable Bonds	2
TPSA	43.42
LogP	5.52
Number Rings	7
Number Aromatic Rings	3
Heavy Atom Count	33
Formal Charge	0
Fraction CSP3	0.41
Exact Mass	436.26
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 136099744

Nmrshiftdb2: 60023086

Chembl: CHEMBL520569

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C(=NCC3)CC(C(=C)C4)CC5N4CCC6C5Nc(c67)cccc7

Level: 1

Mol. Weight: 436.6 g/mol

SMILES: C=C(C1)CCC2N1CCC3C2Nc(c34)cccc4

Level: 0

Mol. Weight: 436.6 g/mol

SMILES: C1CN=Cc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 436.6 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.1
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.02
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -2.07

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.42
Plasma Protein Binding: 77.08
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.4
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.34
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.43
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.63
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -673.58
Rat (Acute): 2.73
Rat (Chronic Oral): 1.86
Fathead Minnow: 6.31
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 521.07
Hydration Free Energy: -3.1
Log(D) at pH=7.4: 3.89
Log(P): 5.63
Log S: -4.89
Log(Vapor Pressure): -10.05
Melting Point: 207.39
pKa Acid: 13.54
pKa Basic: 8.63

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.9541
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.9536
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.9516
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.9482
Nociceptin receptor	P41146	OPRX_HUMAN	Homo sapiens	3	0.9319
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9256
Cytochrome b6	P83791	CYB6_MASLA	Mastigocladus laminosus	3	0.9165
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.9125
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	4	0.9063
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.9045
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.9027
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8990
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8973
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8940
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.8930
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.8914
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8898
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.8841
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.8804
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8723
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8690
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8675
rRNA methylase	Q8DSS3	Q8DSS3_STRMU	Streptococcus mutans serotype c	2	0.8667
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8650
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8636
Aminoglycoside 3'-phosphotransferase	P0A3Y5	KKA3_ENTFL	Enterococcus faecalis	3	0.8613
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	3	0.8609
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.8496
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8429
Epoxide hydrolase	Q41415	Q41415_SOLTU	Solanum tuberosum	3	0.8425
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.8422
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8387
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8376
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8375
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8369
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8318
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.8306
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8304
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8298
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8280
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8278
Lanosterol synthase	P48449	ERG7_HUMAN	Homo sapiens	3	0.8259
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8255
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	3	0.8253
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	3	0.8251
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.8245
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8227
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8202
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8197
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8190
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8173
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8158
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8157
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8156
Caspase-7	P55210	CASP7_HUMAN	Homo sapiens	3	0.8151
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8151
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8142
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.8135
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8119
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8115
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.8098
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8096
Methionine--tRNA ligase	P59078	SYM_BRUSU	Brucella suis biovar 1	5	0.8080
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.8064
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8062
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.8049
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8034
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.8033
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.8028
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8010
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7999
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7998
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7981
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7967
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7957
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7956
Genome polyprotein	Q99AU2	Q99AU2_9HEPC	Hepatitis C virus subtype 1b	3	0.7946
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7943
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7937
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7931
Retinol-binding protein 1	P09455	RET1_HUMAN	Homo sapiens	3	0.7930
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7915
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7903
Cytochrome P450 2E1	P05181	CP2E1_HUMAN	Homo sapiens	3	0.7901
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7900
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7897
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.7895
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7889
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7887
Alcohol dehydrogenase 1C	P00326	ADH1G_HUMAN	Homo sapiens	2	0.7876
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7864
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	3	0.7856
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	2	0.7853
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	3	0.7849
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	4	0.7848
Cholesterol oxidase	P22637	CHOD_BREST	Brevibacterium sterolicum	3	0.7830
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7826
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	3	0.7806
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7806
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7802
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7798
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7793
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7783
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7768
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7765
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	3	0.7757
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7755
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7752
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7737
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7736
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7732
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7732
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	3	0.7727
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7725
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7723
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7723
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7713
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7713
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7709
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7697
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7695
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.7693
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7690
Cholesterol side-chain cleavage enzyme, mitochondrial	P00189	CP11A_BOVIN	Bos taurus	3	0.7689
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7686
Alpha-tocopherol transfer protein	P49638	TTPA_HUMAN	Homo sapiens	4	0.7685
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7684
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	2	0.7683
Alpha-tocopherol transfer protein	P49638	TTPA_HUMAN	Homo sapiens	4	0.7670
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7666
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7664
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7655
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7654
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7652
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7651
Matrix metalloproteinase-20	O60882	MMP20_HUMAN	Homo sapiens	3	0.7650
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7650
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7641
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7634
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7631
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7630
NPC intracellular cholesterol transporter 1	O15118	NPC1_HUMAN	Homo sapiens	2	0.7625
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	3	0.7623
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7606
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7604
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7604
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7595
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7594
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7593
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7584
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7583
Methionine--tRNA ligase	Q2YQ76	Q2YQ76_BRUA2	Brucella abortus	5	0.7581
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7572
Putative snRNP Sm-like protein	Q8ZYG5	Q8ZYG5_PYRAE	Pyrobaculum aerophilum	2	0.7568
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7566
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7565
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.7554
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7549
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7546
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7546
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7542
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7539
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7536
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7534
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7526
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	2	0.7525
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7524
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7512
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7511
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7510
Thyroid hormone receptor alpha	P04625	THA_CHICK	Gallus gallus	3	0.7508
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	2	0.7507
UDP-N-acetylenolpyruvoylglucosamine reductase	P08373	MURB_ECOLI	Escherichia coli	3	0.7498
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7494
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7492
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7490
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7486
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7479
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7476
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7467
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7467
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7459
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7455
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7454
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.7445
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7442
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7437
Serine/threonine-protein kinase N1	Q16512	PKN1_HUMAN	Homo sapiens	3	0.7437
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7433
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7424
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7419
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7419
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	2	0.7418
Casein kinase I isoform gamma-2	P78368	KC1G2_HUMAN	Homo sapiens	3	0.7417
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7416
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7401
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7397
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	2	0.7396
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	2	0.7396
Chorismate pyruvate-lyase	P26602	UBIC_ECOLI	Escherichia coli	2	0.7390
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7389
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	3	0.7385
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7384
Fatty acid-binding protein, intestinal	P02693	FABPI_RAT	Rattus norvegicus	3	0.7382
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7382
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7380
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7379
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7377
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7374
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7374
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7372
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7371
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7365
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7361
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7361
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	2	0.7358
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	2	0.7353
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7353
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7351
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	2	0.7347
Orf1ab polyprotein	Q6T1E9	Q6T1E9_CVHSA	SARS coronavirus CUHK-L2	3	0.7345
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7339
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7338
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q63707	PYRD_RAT	Rattus norvegicus	3	0.7336
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7335
Class B acid phosphatase	P0AE22	APHA_ECOLI	Escherichia coli	2	0.7334
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7325
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7324
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7324
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7323
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7323
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7322
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7321
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	2	0.7318
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7318
Calmodulin-1	P0DP29	CALM1_RAT	Rattus norvegicus	2	0.7317
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7317
Histidinol dehydrogenase	P06988	HISX_ECOLI	Escherichia coli	2	0.7317
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7313
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7312
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7308
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7307
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7306
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7302
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7302
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7301
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7301
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7294
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7293
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7290
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7287
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	2	0.7285
Aldo-keto reductase family 1 member A1	P50578	AK1A1_PIG	Sus scrofa	3	0.7283
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7280
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7276
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7275
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7275
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7275
Trichodiene synthase	P13513	TRI5_FUSSP	Fusarium sporotrichioides	2	0.7274
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7274
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7265
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7263
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	2	0.7260
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7254
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7254
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7252
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7247
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7245
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7241
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7240
Aspartate carbamoyltransferase catalytic subunit	P0A786	PYRB_ECOLI	Escherichia coli	2	0.7240
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7237
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7235
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7232
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	2	0.7232
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7232
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	2	0.7230
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7230
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7229
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7223
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7221
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	2	0.7220
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	O95340	PAPS2_HUMAN	Homo sapiens	2	0.7219
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	2	0.7218
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	2	0.7218
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7215
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7213
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7213
Serine protease 1	P00760	TRY1_BOVIN	Bos taurus	3	0.7208
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7207
Feruloyl esterase A	O42807	FAEA_ASPNG	Aspergillus niger	2	0.7207
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.7204
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7202
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7200
Isochorismate pyruvate lyase	Q51507	PCHB_PSEAE	Pseudomonas aeruginosa	2	0.7199
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7198
DNA mismatch repair protein MutS	Q56215	MUTS_THEAQ	Thermus aquaticus	2	0.7196
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7195
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7192
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	2	0.7192
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7191
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	2	0.7190
Cellular retinol-binding protein type II	Q8UVG6	Q8UVG6_DANRE	Danio rerio	3	0.7188
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	2	0.7188
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7188
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7184
Fatty acid-binding protein 10-A, liver basic	Q9I8L5	FA10A_DANRE	Danio rerio	2	0.7183
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7183
4-substituted benzoates-glutamate ligase GH3.12	Q9LYU4	GH312_ARATH	Arabidopsis thaliana	2	0.7182
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7179
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7179
Alpha-tocopherol transfer protein	Q8BWP5	TTPA_MOUSE	Mus musculus	4	0.7176
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7175
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7175
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7174
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.7174
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7173
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.7170
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7169
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.7168
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7167
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7166
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7165
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	2	0.7165
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7159
Carbonic anhydrase 5A, mitochondrial	P23589	CAH5A_MOUSE	Mus musculus	2	0.7157
Genome polyprotein	P27395	POLG_JAEV1	Japanese encephalitis virus	2	0.7156
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7155
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7154
Caffeic acid 3-O-methyltransferase	P28002	COMT1_MEDSA	Medicago sativa	2	0.7153
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	P12995	BIOA_ECOLI	Escherichia coli	2	0.7152
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	2	0.7149
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7144
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7144
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	2	0.7143
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7143
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7141
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	2	0.7141
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	2	0.7141
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7137
Thiamine pyrophosphokinase	O34664	THIN_BACSU	Bacillus subtilis	3	0.7127
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7127
Endoplasmin, putative	Q8I0V4	Q8I0V4_PLAF7	Plasmodium falciparum	3	0.7126
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7125
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.7124
Purine nucleoside phosphorylase, putative	A2E7Y6	A2E7Y6_TRIVA	Trichomonas vaginalis	2	0.7122
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase	O58523	TYW2_PYRHO	Pyrococcus horikoshii	2	0.7122
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7118
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7116
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7116
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7114
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7111
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7110
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7107
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7102
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7101
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7100
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7097
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7095
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7094
Karilysin	D0EM77	KLY_TANFA	Tannerella forsythia	2	0.7094
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7093
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	2	0.7092
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7091
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7090
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7088
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7084
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7083
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7080
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	2	0.7079
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7078
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7077
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7074
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7071
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7071
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7068
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7068
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7068
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	2	0.7066
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7065
Aspartate carbamoyltransferase catalytic subunit	P0A786	PYRB_ECOLI	Escherichia coli	2	0.7062
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7061
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7060
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7059
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7049
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7049
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7045
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7045
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7044
Squalene synthase	P37268	FDFT_HUMAN	Homo sapiens	3	0.7042
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7042
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7041
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	2	0.7038
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7036
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7035
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	3	0.7032
Ectonucleoside triphosphate diphosphohydrolase I	Q5ZUA2	Q5ZUA2_LEGPH	Legionella pneumophila subsp. pneumophila	2	0.7032
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7027
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7026
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7026
Putative cytochrome P450 120	Q59990	CP120_SYNY3	Synechocystis sp	3	0.7025
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.7024
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7023
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7022
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7020
Genome polyprotein	P03303	POLG_HRV14	Human rhinovirus 14	3	0.7019
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7019
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7015
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7014
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	2	0.7011
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7008
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7005
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	3	0.7002
Naphthalene 1,2-dioxygenase system, large oxygenase component	P0A110	NDOB_PSEPU	Pseudomonas putida	2	0.7001
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7001
Anthranilate phosphoribosyltransferase	P50384	TRPD_SACS2	Saccharolobus solfataricus	2	0.7001

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