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Usambarensine

Family: Plantae - Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indole Alkaloid

Canonical Smiles	C/C=C\1/CN2CCc3c([C@@H]2C[C@@H]1Cc1nccc2c1[nH]c1c2cccc1)[nH]c1c3cccc1
InChI	InChI=1S/C29H28N4/c1-2-18-17-33-14-12-23-21-8-4-6-10-25(21)32-29(23)27(33)16-19(18)15-26-28-22(11-13-30-26)20-7-3-5-9-24(20)31-28/h2-11,13,19,27,31-32H,12,14-17H2,1H3/b18-2-/t19-,27-/m0/s1
InChIKey	VUMZOPMHFVDIMF-NLLHOBBWSA-N
Formula	C₂₉H₂₈N₄
HBA	2
HBD	2
MW	432.57
Rotatable Bonds	2
TPSA	47.71
LogP	6.31
Number Rings	7
Number Aromatic Rings	5
Heavy Atom Count	33
Formal Charge	0
Fraction CSP3	0.28
Exact Mass	432.23
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 5281413

Cas: 36150-14-8

Gnps: CCMSLIB00004680070

Zinc: ZINC000030726809

Kegg Ligand: C09249

Chebi: 9910

Nmrshiftdb2: 60023069

Metabolights: MTBLC9910

Chembl: CHEMBL490322

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C4N(CC3)CC(=C)C(C4)Cc(ncc5)c6[nH]c(c7c56)cccc7

Level: 1

Mol. Weight: 432.57 g/mol

SMILES: C1CC(=C)CN(CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 432.57 g/mol

SMILES: c1cncc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 432.57 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.57
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.98
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -1.27

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.7
Plasma Protein Binding: 87.84
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 3.73
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.36
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.11
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.56
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -673.75
Rat (Acute): 2.97
Rat (Chronic Oral): 1.53
Fathead Minnow: 7.13
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 559.87
Hydration Free Energy: -3.25
Log(D) at pH=7.4: 4.76
Log(P): 6.08
Log S: -5.6
Log(Vapor Pressure): -10.98
Melting Point: 307.21
pKa Acid: 14.57
pKa Basic: 8.07

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.9773
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.9635
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.9617
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.9402
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.9400
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9302
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.9279
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9270
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.9253
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.9235
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.9192
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.9141
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.9130
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.9090
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.9015
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8982
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.8946
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8927
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8897
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8884
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8840
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.8836
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.8826
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8787
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8767
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.8746
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.8605
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8586
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8582
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.8554
Calmodulin-1	P0DP29	CALM1_RAT	Rattus norvegicus	3	0.8549
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8531
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.8439
Polyamine oxidase FMS1	P50264	FMS1_YEAST	Saccharomyces cerevisiae	3	0.8386
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.8385
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.8356
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8356
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8354
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8308
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8304
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.8286
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8264
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.8249
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8247
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8242
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.8227
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8220
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8202
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8189
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8174
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8153
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.8105
Flavin reductase (NADPH)	P30043	BLVRB_HUMAN	Homo sapiens	3	0.8097
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.8091
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8087
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8069
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.8065
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8052
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8041
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8032
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8028
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8023
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8017
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.8002
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7966
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7966
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7932
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7928
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7926
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7926
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7916
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7912
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7907
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7887
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7882
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7881
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7872
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7846
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	2	0.7843
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7842
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.7820
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7814
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7810
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.7808
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7794
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7791
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7786
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7780
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7780
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7775
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7772
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7763
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7734
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7732
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	4	0.7728
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7726
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7723
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7722
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7715
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7714
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7710
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7709
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7706
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7688
Serine protease 1	P00760	TRY1_BOVIN	Bos taurus	4	0.7668
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7651
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7641
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7631
Albumin	P02769	ALBU_BOVIN	Bos taurus	3	0.7620
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7611
UDP-N-acetylenolpyruvoylglucosamine reductase	P08373	MURB_ECOLI	Escherichia coli	3	0.7606
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7606
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7601
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7601
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7591
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7589
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.7587
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7582
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7582
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7547
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7542
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7539
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7536
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7528
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7527
Genome polyprotein	Q99AU2	Q99AU2_9HEPC	Hepatitis C virus subtype 1b	3	0.7513
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7511
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7508
V-1 PROTEASE protein	Q9Q288	Q9Q288_9HIV1	Human immunodeficiency virus 1	3	0.7502
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7493
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7490
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7479
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7478
Pyruvate oxidase	P37063	POXB_LACPL	Lactiplantibacillus plantarum	3	0.7476
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7474
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7473
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	4	0.7471
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7465
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7454
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7454
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7452
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7449
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7446
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7443
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	2	0.7435
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7431
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7429
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7424
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7413
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7408
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7405
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7403
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7397
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7397
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7395
Benzaldehyde lyase	Q9F4L3	Q9F4L3_PSEFL	Pseudomonas fluorescens	3	0.7390
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7390
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7389
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7384
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	3	0.7383
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7383
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7372
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7372
Protein-tyrosine kinase 2-beta	Q14289	FAK2_HUMAN	Homo sapiens	4	0.7367
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7366
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	3	0.7362
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7354
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7347
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7332
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7326
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7325
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7325
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7324
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7323
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7318
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7316
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	2	0.7314
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7312
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7311
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7304
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7302
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7299
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7297
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7292
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7266
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7264
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7260
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.7257
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7257
3',5'-cyclic-AMP phosphodiesterase 4B	Q07343	PDE4B_HUMAN	Homo sapiens	4	0.7250
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7244
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7236
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7236
Dipeptidyl peptidase 4	P22411	DPP4_PIG	Sus scrofa	3	0.7225
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7224
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7217
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7215
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7210
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.7208
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7205
Diamine oxidase [copper-containing]	P19801	AOC1_HUMAN	Homo sapiens	3	0.7197
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7195
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7195
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	2	0.7189
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7188
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	4	0.7184
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	3	0.7184
Envelope glycoprotein gp160	Q0ED31	Q0ED31_9HIV1	Human immunodeficiency virus 1	4	0.7182
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	2	0.7178
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7174
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7174
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.7172
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7168
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7165
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7159
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7149
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	2	0.7140
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7136
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7135
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7133
Benzoylformate decarboxylase	P20906	MDLC_PSEPU	Pseudomonas putida	3	0.7129
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7126
4-hydroxyphenylpyruvate dioxygenase	P93836	HPPD_ARATH	Arabidopsis thaliana	3	0.7120
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7119
Putative snRNP Sm-like protein	Q8ZYG5	Q8ZYG5_PYRAE	Pyrobaculum aerophilum	2	0.7109
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	P9WK11	MEND_MYCTU	Mycobacterium tuberculosis	3	0.7108
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	3	0.7105
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7097
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7096
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7096
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	2	0.7093
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7090
Troponin C, slow skeletal and cardiac muscles	P63316	TNNC1_HUMAN	Homo sapiens	2	0.7090
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7088
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.7083
Nociceptin receptor	P41146	OPRX_HUMAN	Homo sapiens	3	0.7077
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7076
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7075
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7068
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	4	0.7066
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7053
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7050
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	3	0.7049
Cholesterol 24-hydroxylase	Q9Y6A2	CP46A_HUMAN	Homo sapiens	2	0.7048
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7045
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7043
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7034
Mitogen-activated protein kinase 1	P63086	MK01_RAT	Rattus norvegicus	3	0.7030
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7030
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7028
Carbonic anhydrase 4	P22748	CAH4_HUMAN	Homo sapiens	3	0.7025
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7021
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7020
Bcl-2-like protein 1	Q07817	B2CL1_HUMAN	Homo sapiens	3	0.7019
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7016
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	2	0.7016
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7013
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7011
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7008
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7003
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7003

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