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Nb-methylusambarensine

Family: Plantae - Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indole Alkaloid

Canonical Smiles	C/C=C\1/C[N+]2(C)CCc3c([C@@H]2C[C@@H]1Cc1nccc2c1[nH]c1c2cccc1)[nH]c1c3cccc1
InChI	InChI=1S/C30H31N4/c1-3-19-18-34(2)15-13-24-22-9-5-7-11-26(22)33-30(24)28(34)17-20(19)16-27-29-23(12-14-31-27)21-8-4-6-10-25(21)32-29/h3-12,14,20,28,32-33H,13,15-18H2,1-2H3/q+1/b19-3-/t20-,28-,34?/m0/s1
InChIKey	QCLXHLAQWSKUQF-MPMWDDIASA-N
Formula	C₃₀H₃₁N₄+
HBA	1
HBD	2
MW	447.61
Rotatable Bonds	2
TPSA	44.47
LogP	6.45
Number Rings	7
Number Aromatic Rings	5
Heavy Atom Count	34
Formal Charge	1
Fraction CSP3	0.3
Exact Mass	447.25
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 134716676

Gnps: CCMSLIB00004680016

Zinc: ZINC000038180855

Chebi: 141928

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C4[NH+](CC3)CC(=C)C(C4)Cc(ncc5)c6[nH]c(c7c56)cccc7

Level: 1

Mol. Weight: 447.61 g/mol

SMILES: C1CC(=C)C[NH+](CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 447.61 g/mol

SMILES: c1cncc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 447.61 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.61
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.94
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -1.24

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.52
Plasma Protein Binding: 83.46
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 3.6
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Safe
Bioconcentration Factor: 2.39
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.03
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.7
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -898.33
Rat (Acute): 2.96
Rat (Chronic Oral): 1.25
Fathead Minnow: 8.5
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 580.18
Hydration Free Energy: -3.06
Log(D) at pH=7.4: 3.51
Log(P): 2.56
Log S: -2.86
Log(Vapor Pressure): -12.41
Melting Point: 354.95
pKa Acid: 12.27
pKa Basic: 7.81

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.9676
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.9514
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.9394
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9387
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9281
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.9090
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.9078
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.9007
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8994
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8990
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8971
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8942
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8935
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8881
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.8869
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.8848
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8845
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8844
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.8832
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.8760
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.8725
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.8662
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.8598
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8589
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8433
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8408
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8277
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8269
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.8263
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.8251
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.8214
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.8169
Aklanonic acid methyl ester cyclase AcmA	O52646	DNRD_STRGJ	Streptomyces galilaeus	3	0.8159
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8089
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8061
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8047
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8035
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8019
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.8017
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7997
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7995
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7980
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7948
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7936
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7935
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7920
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7919
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7917
Caspase-7	P55210	CASP7_HUMAN	Homo sapiens	3	0.7915
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7881
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7865
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7861
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.7860
Albumin	P02769	ALBU_BOVIN	Bos taurus	3	0.7853
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7838
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7830
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7807
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7794
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7785
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7783
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7771
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7752
D-alanine--D-alanine ligase	Q5HEB7	DDL_STAAC	Staphylococcus aureus	3	0.7735
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7726
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7719
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7704
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7701
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7690
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7686
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7675
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7649
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7646
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7620
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7610
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7602
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7600
Genome polyprotein	Q99AU2	Q99AU2_9HEPC	Hepatitis C virus subtype 1b	3	0.7595
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7595
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	3	0.7584
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7579
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7575
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7530
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7525
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7523
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7514
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7508
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7506
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7497
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7486
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7485
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7479
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7473
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7460
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7459
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7431
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7426
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7421
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7418
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	2	0.7418
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7411
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7411
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7411
UDP-N-acetylenolpyruvoylglucosamine reductase	P08373	MURB_ECOLI	Escherichia coli	3	0.7410
Troponin C, slow skeletal and cardiac muscles	P63316	TNNC1_HUMAN	Homo sapiens	3	0.7408
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7401
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7389
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7388
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7381
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7380
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7378
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7363
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7359
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7341
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7338
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7335
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7332
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7327
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	3	0.7325
Terminal oxygenase component of carbazole	Q84II6	Q84II6_JANS3	Janthinobacterium sp	3	0.7322
Inorganic pyrophosphatase	Q3JUV5	Q3JUV5_BURP1	Burkholderia pseudomallei	3	0.7313
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7312
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7311
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	2	0.7297
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7296
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7287
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7280
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7279
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7277
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7271
Diamine oxidase [copper-containing]	P19801	AOC1_HUMAN	Homo sapiens	3	0.7268
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7266
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7261
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	2	0.7241
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7239
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7234
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7227
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	4	0.7214
Pyruvate oxidase	P37063	POXB_LACPL	Lactiplantibacillus plantarum	3	0.7199
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7199
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7195
D(3) dopamine receptor	P35462	DRD3_HUMAN	Homo sapiens	3	0.7191
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7187
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	3	0.7181
Aldose reductase-related protein 2	P45377	ALD2_MOUSE	Mus musculus	3	0.7180
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7179
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7177
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7169
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7167
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7165
Naphthalene 1,2-dioxygenase system, large oxygenase component	P0A110	NDOB_PSEPU	Pseudomonas putida	2	0.7149
Genome polyprotein	P03303	POLG_HRV14	Human rhinovirus 14	3	0.7141
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7127
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7126
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7117
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7114
Transcriptional regulator	Q8NMG3	Q8NMG3_CORGL	Corynebacterium glutamicum	3	0.7108
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7107
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7107
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7101
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7090
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7088
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7087
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7082
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7080
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7079
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7079
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7078
Botulinum neurotoxin type A	P0DPI0	BXA1_CLOBO	Clostridium botulinum	4	0.7074
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7072
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7071
Actin, alpha skeletal muscle	P68135	ACTS_RABIT	Oryctolagus cuniculus	3	0.7068
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7067
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7059
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7058
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7054
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7047
Nociceptin receptor	P41146	OPRX_HUMAN	Homo sapiens	3	0.7030
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7030
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7029
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7027
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7017
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7014
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7006

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