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Usambarine

Family: Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indole Alkaloid

Canonical Smiles	C=C[C@H]1CN2CCc3c([C@@H]2C[C@@H]1C[C@@H]1N(C)CCc2c1[nH]c1c2cccc1)[nH]c1c3cccc1
InChI	InChI=1S/C30H34N4/c1-3-19-18-34-15-13-24-22-9-5-7-11-26(22)32-30(24)28(34)17-20(19)16-27-29-23(12-14-33(27)2)21-8-4-6-10-25(21)31-29/h3-11,19-20,27-28,31-32H,1,12-18H2,2H3/t19-,20-,27-,28-/m0/s1
InChIKey	JICXOAIUPFUZPK-DXBSEXLMSA-N
Formula	C₃₀H₃₄N₄
HBA	2
HBD	2
MW	450.63
Rotatable Bonds	3
TPSA	38.06
LogP	5.99
Number Rings	7
Number Aromatic Rings	4
Heavy Atom Count	34
Formal Charge	0
Fraction CSP3	0.4
Exact Mass	450.28
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 442121

Cas: 35226-29-0

Gnps: CCMSLIB00004680071

Zinc: ZINC000004097973

Kegg Ligand: C09250

Chebi: 9911

Nmrshiftdb2: 60023083

Metabolights: MTBLC9911

Chembl: CHEMBL1214432

Comptox: DTXSID20331742

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C(NCC3)CC(C4)CCN(CC5)C4c(c5c67)[nH]c6cccc7

Level: 1

Mol. Weight: 410.57 g/mol

SMILES: C1CCCN(CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 226.32 g/mol

SMILES: C1CNCc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 172.23 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.5
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.49
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -0.22

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.27
Plasma Protein Binding: 89.5
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.9
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.93
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.38
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 6.05
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -987.39
Rat (Acute): 2.59
Rat (Chronic Oral): 1.78
Fathead Minnow: 6.97
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 480.56
Hydration Free Energy: -3.0
Log(D) at pH=7.4: 4.97
Log(P): 5.69
Log S: -5.08
Log(Vapor Pressure): -9.39
Melting Point: 204.74
pKa Acid: 13.25
pKa Basic: 6.5

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9625
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.9624
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.9536
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.9479
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9474
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9423
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.9414
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.9369
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.9359
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.9307
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	3	0.9258
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.9206
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.9138
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.9120
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.9091
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.8850
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8845
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8802
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8766
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8756
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.8746
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8739
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8737
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8667
Cholesterol 24-hydroxylase	Q9Y6A2	CP46A_HUMAN	Homo sapiens	3	0.8653
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8627
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8602
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.8580
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8576
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8562
Aklanonic acid methyl ester cyclase AcmA	O52646	DNRD_STRGJ	Streptomyces galilaeus	3	0.8532
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8506
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8503
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.8464
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8438
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8413
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8406
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8390
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8341
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8334
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8334
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8253
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8248
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	4	0.8234
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8231
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8163
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8153
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	3	0.8147
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8125
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	3	0.8125
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8103
mRNA cap guanine-N7 methyltransferase	O43148	MCES_HUMAN	Homo sapiens	3	0.8062
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8060
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8025
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.8023
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7998
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	3	0.7984
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7946
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7944
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.7908
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7903
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7893
Serine protease 1	P00760	TRY1_BOVIN	Bos taurus	4	0.7885
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7870
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7868
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7861
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7860
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7851
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7848
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7837
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.7831
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7823
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7822
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7817
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7796
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7795
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7769
rRNA methylase	Q8DSS3	Q8DSS3_STRMU	Streptococcus mutans serotype c	2	0.7760
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7748
Aldose reductase-related protein 2	P45377	ALD2_MOUSE	Mus musculus	3	0.7745
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7733
Flavin reductase (NADPH)	P30043	BLVRB_HUMAN	Homo sapiens	3	0.7732
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7714
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7713
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7706
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7703
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7699
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7692
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	3	0.7688
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7675
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7673
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.7638
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	2	0.7636
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	4	0.7631
D(3) dopamine receptor	P35462	DRD3_HUMAN	Homo sapiens	3	0.7630
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7624
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7623
Naphthalene 1,2-dioxygenase system, large oxygenase component	P0A110	NDOB_PSEPU	Pseudomonas putida	2	0.7623
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7622
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7621
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7608
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.7597
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7594
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7592
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7592
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7585
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	4	0.7583
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7565
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7535
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7522
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7520
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7502
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7496
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7482
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7476
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7469
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7467
Putative snRNP Sm-like protein	Q8ZYG5	Q8ZYG5_PYRAE	Pyrobaculum aerophilum	2	0.7452
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7445
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7444
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7439
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7439
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.7437
UDP-N-acetylenolpyruvoylglucosamine reductase	P08373	MURB_ECOLI	Escherichia coli	3	0.7434
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7431
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7430
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7422
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7421
Probable nicotinate-nucleotide adenylyltransferase	C3L5T6	NADD_BACAC	Bacillus anthracis	3	0.7420
Envelope glycoprotein gp160	Q0ED31	Q0ED31_9HIV1	Human immunodeficiency virus 1	4	0.7419
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	2	0.7403
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7388
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7383
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7363
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7352
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7349
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7346
Adenosine 5'-monophosphoramidase HINT1	P49773	HINT1_HUMAN	Homo sapiens	3	0.7345
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7341
Gag-Pol polyprotein	P04587	POL_HV1B5	Human immunodeficiency virus type 1 group M subtype B	3	0.7341
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7332
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	2	0.7329
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7325
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7318
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7313
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7311
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	2	0.7303
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7300
Botulinum neurotoxin type B	P10844	BXB_CLOBO	Clostridium botulinum	3	0.7294
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7289
Acidic mammalian chitinase	Q9BZP6	CHIA_HUMAN	Homo sapiens	2	0.7289
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7288
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7281
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7279
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.7279
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7275
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	2	0.7274
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7273
Dicamba O-demethylase, oxygenase component	Q5S3I3	DDMC_STEMA	Stenotrophomonas maltophilia	2	0.7271
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7271
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7269
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7260
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	4	0.7259
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.7256
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7241
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	2	0.7241
Catechol 2,3-dioxygenase	Q6REQ5	Q6REQ5_9NOCA	Rhodococcus sp. DK17	3	0.7237
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7237
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7227
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7226
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7221
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7220
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7217
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	4	0.7209
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	2	0.7207
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7206
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7203
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7200
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7192
Endolysin	P00720	ENLYS_BPT4	Enterobacteria phage T4	3	0.7190
Histone-lysine N-methyltransferase EHMT2	Q96KQ7	EHMT2_HUMAN	Homo sapiens	3	0.7186
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7186
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7183
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7183
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7168
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7167
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	2	0.7165
Acidic mammalian chitinase	Q9BZP6	CHIA_HUMAN	Homo sapiens	3	0.7163
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7162
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7161
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7145
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7140
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7129
Genome polyprotein	P03303	POLG_HRV14	Human rhinovirus 14	3	0.7126
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7125
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7122
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7120
Short form salivary protein D7R4	Q7PNF2	Q9BIH3_ANOGA	Anopheles gambiae	2	0.7116
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7115
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7113
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7110
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7110
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7108
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7107
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7107
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7107
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7106
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7099
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7095
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7092
Succinyl-CoA:acetate CoA-transferase	B3EY95	SCACT_ACEAC	Acetobacter aceti	2	0.7090
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7088
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7086
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7078
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7075
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7072
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7072
Tyrosine-protein kinase receptor TYRO3	P55144	TYRO3_MOUSE	Mus musculus	3	0.7072
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7072
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.7069
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7068
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7068
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7067
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7064
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7058
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7054
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7053
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7038
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7036
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.7036
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7031
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7026
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7011
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	3	0.7008
Toll-like receptor 8	Q9NR97	TLR8_HUMAN	Homo sapiens	3	0.7004
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7004
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7001

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