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Isostrychnopentamine

Family: Plantae - Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indole Alkaloid

Canonical Smiles	C=C[C@H]1CN2CCc3c([C@@H]2C[C@@H]1C[C@@H]1N(C)CCc2c1[nH]c1c2cccc1)[nH]c1c3ccc(c1[C@@H]1CCCN1C)O
InChI	InChI=1S/C35H43N5O/c1-4-21-20-40-17-14-26-24-11-12-31(41)32(28-10-7-15-38(28)2)35(24)37-34(26)30(40)19-22(21)18-29-33-25(13-16-39(29)3)23-8-5-6-9-27(23)36-33/h4-6,8-9,11-12,21-22,28-30,36-37,41H,1,7,10,13-20H2,2-3H3/t21-,22-,28-,29-,30-/m0/s1
InChIKey	PHLJPJICTIGOKC-RZVVXSKCSA-N
Formula	C₃₅H₄₃N₅O
HBA	4
HBD	3
MW	549.76
Rotatable Bonds	4
TPSA	61.53
LogP	6.46
Number Rings	8
Number Aromatic Rings	4
Heavy Atom Count	41
Formal Charge	0
Fraction CSP3	0.49
Exact Mass	549.35
Number of Lipinski Rule Violations	2

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 6712642

Gnps: CCMSLIB00004680002

Zinc: ZINC000006004508

Chebi: 141915

Nmrshiftdb2: 70053771

Chembl: CHEMBL1213395

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C(NCC3)CC(C4)CCN(CC5)C4c(c5c67)[nH]c6c(ccc7)C8CCCN8

Level: 2

Mol. Weight: 549.76 g/mol

SMILES: c1cccc2[nH]c(c3c12)C(NCC3)CC(C4)CCN(CC5)C4c(c5c67)[nH]c6cccc7

Level: 1

Mol. Weight: 549.76 g/mol

SMILES: C1CCCN(CC2)C1c(c2c34)[nH]c3c(ccc4)C5CCCN5

Level: 1

Mol. Weight: 549.76 g/mol

SMILES: C1CCCN(CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 549.76 g/mol

SMILES: C1CNCc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 549.76 g/mol

SMILES: C1CCNC1

Level: 0

Mol. Weight: 549.76 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.75
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Non-Absorbed
Madin-Darby Canine Kidney: -5.37
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 18.11

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.86
Plasma Protein Binding: 90.51
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.86
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.99
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.66
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 6.15
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -32122.93
Rat (Acute): 2.79
Rat (Chronic Oral): 2.07
Fathead Minnow: 52.06
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 609.81
Hydration Free Energy: -2.92
Log(D) at pH=7.4: 4.57
Log(P): 5.09
Log S: -4.84
Log(Vapor Pressure): -22.01
Melting Point: 229.01
pKa Acid: 10.72
pKa Basic: 7.08

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.9609
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.9568
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.9376
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9196
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.9173
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.9145
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.9130
Coniferyl alcohol 9-O-methyltransferase	A6XNE6	A6XNE6_9ROSI	Linum nodiflorum	3	0.9034
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8940
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8876
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8869
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.8862
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8860
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8821
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8799
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8721
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8672
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.8653
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.8631
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8626
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8624
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8620
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8598
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8564
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8555
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8534
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8534
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.8519
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8518
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8511
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.8471
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8463
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8423
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8418
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8348
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8343
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8332
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8285
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8284
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8283
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8280
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8269
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8269
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.8224
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	3	0.8217
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8202
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.8175
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.8170
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8136
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8124
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8094
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8087
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.8071
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8063
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8060
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	3	0.8052
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8037
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	3	0.8025
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8006
S-methyl-5'-thioadenosine phosphorylase	Q13126	MTAP_HUMAN	Homo sapiens	3	0.7991
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7989
Seed lectin subunit I	P05045	LEC1_VIGUC	Vigna unguiculata subsp. cylindrica	3	0.7987
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7978
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7973
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7941
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7937
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7926
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7899
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7866
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	3	0.7864
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7855
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7854
Integrin alpha-IIb	P08514	ITA2B_HUMAN	Homo sapiens	3	0.7840
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7816
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7798
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	3	0.7791
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7762
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7747
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7706
Probable nicotinate-nucleotide adenylyltransferase	C3L5T6	NADD_BACAC	Bacillus anthracis	3	0.7705
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7697
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7689
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7688
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7684
mRNA cap guanine-N7 methyltransferase	O43148	MCES_HUMAN	Homo sapiens	3	0.7668
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7649
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	3	0.7640
Aldose reductase-related protein 2	P45377	ALD2_MOUSE	Mus musculus	3	0.7639
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7633
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7628
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7622
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.7600
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic	Q1XH05	HGL1B_WHEAT	Triticum aestivum	3	0.7589
Purine phosphoribosyltransferase (GpT-1)	Q97W95	Q97W95_SACS2	Saccharolobus solfataricus	4	0.7586
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7574
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7569
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	3	0.7568
RAC-alpha serine/threonine-protein kinase	P31749	AKT1_HUMAN	Homo sapiens	3	0.7561
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7557
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7549
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7548
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7532
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7509
Cobalt-precorrin-4 C(11)-methyltransferase	O87696	CBIF_BACME	Priestia megaterium	3	0.7490
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7478
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.7474
Short form salivary protein D7R4	Q7PNF2	Q9BIH3_ANOGA	Anopheles gambiae	3	0.7474
43.2 kDa salivary protein	Q5WPU9	Q5WPU9_LUTLO	Lutzomyia longipalpis	3	0.7471
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7444
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7441
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7420
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7406
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7395
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7365
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7364
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7363
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7360
Thiamine-monophosphate kinase	O67883	THIL_AQUAE	Aquifex aeolicus	3	0.7359
Troponin C, slow skeletal and cardiac muscles	P63316	TNNC1_HUMAN	Homo sapiens	3	0.7356
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7337
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	4	0.7334
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	3	0.7329
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.7312
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7312
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7305
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Q15750	TAB1_HUMAN	Homo sapiens	3	0.7301
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7298
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7287
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7271
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7260
Histone-lysine N-methyltransferase EHMT2	Q96KQ7	EHMT2_HUMAN	Homo sapiens	3	0.7251
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic	Q9FYS3	HGGL_SECCE	Secale cereale	3	0.7244
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7244
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7240
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7231
Genome polyprotein	C0LMU0	C0LMU0_9FLAV	dengue virus type 3	3	0.7230
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7228
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7227
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7219
D-alanine--D-alanine ligase	Q5HEB7	DDL_STAAC	Staphylococcus aureus	3	0.7214
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7213
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7192
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7189
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7183
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7179
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7174
DNA (cytosine-5)-methyltransferase 3A	O88508	DNM3A_MOUSE	Mus musculus	3	0.7173
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7165
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7164
GMP reductase	Q81JJ9	GUAC_BACAN	Bacillus anthracis	2	0.7164
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	3	0.7157
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7138
histidine kinase	Q9WZV7	Q9WZV7_THEMA	Thermotoga maritima	3	0.7136
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7126
Envelope glycoprotein gp160	Q0ED31	Q0ED31_9HIV1	Human immunodeficiency virus 1	4	0.7118
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	4	0.7088
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7087
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	3	0.7078
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7075
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7073
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7068
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7054
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7045
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7041
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7035
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7032
Heat shock 70 kDa protein 1A	P0DMV8	HS71A_HUMAN	Homo sapiens	3	0.7030
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7030
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7028
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	5	0.7026
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7020
Ethanolamine-phosphate cytidylyltransferase	Q99447	PCY2_HUMAN	Homo sapiens	3	0.7009
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7004

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