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Isostrychnofoline

Family: Plantae - Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Oxindole Alkaloid

Canonical Smiles	C=CC1CN2CCC3(C2CC1CC1N(C)CCc2c1[nH]c1c2cccc1)C(=O)Nc1c3ccc(c1)O
InChI	InChI=1S/C30H34N4O2/c1-3-18-17-34-13-11-30(23-9-8-20(35)16-25(23)32-29(30)36)27(34)15-19(18)14-26-28-22(10-12-33(26)2)21-6-4-5-7-24(21)31-28/h3-9,16,18-19,26-27,31,35H,1,10-15,17H2,2H3,(H,32,36)
InChIKey	YAXAQXBFDAJGGS-UHFFFAOYSA-N
Formula	C₃₀H₃₄N₄O₂
HBA	4
HBD	3
MW	482.63
Rotatable Bonds	3
TPSA	71.6
LogP	4.58
Number Rings	7
Number Aromatic Rings	3
Heavy Atom Count	36
Formal Charge	0
Fraction CSP3	0.43
Exact Mass	482.27
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 155297

Cas: 69351-04-8

Nmrshiftdb2: 70124321

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C(NCC3)CC(C4)CCN(CC5)C4C56c7c(NC6=O)cccc7

Level: 1

Mol. Weight: 482.63 g/mol

SMILES: c1cccc(NC2=O)c1C23C4N(CC3)CCCC4

Level: 0

Mol. Weight: 482.63 g/mol

SMILES: C1CNCc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 482.63 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.62
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.35
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 0.17

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.81
Plasma Protein Binding: 43.3
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 11.09
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.88
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.25
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.49
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -2026.86
Rat (Acute): 2.64
Rat (Chronic Oral): 1.8
Fathead Minnow: 9.46
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 487.67
Hydration Free Energy: -2.79
Log(D) at pH=7.4: 3.48
Log(P): 3.25
Log S: -4.17
Log(Vapor Pressure): -8.72
Melting Point: 205.23
pKa Acid: 8.48
pKa Basic: 7.08

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.9866
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.9800
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.9619
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.9539
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.9507
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9404
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9318
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	3	0.9177
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.9164
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.9150
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.9091
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.9066
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.9014
Bifunctional glutamate/proline--tRNA ligase	P07814	SYEP_HUMAN	Homo sapiens	3	0.9011
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.8983
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	3	0.8981
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8866
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8846
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.8793
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8772
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8770
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8717
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8664
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8638
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	3	0.8632
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8610
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8502
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	3	0.8490
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8466
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8464
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.8452
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8444
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8441
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8427
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8392
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8385
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8376
D(3) dopamine receptor	P35462	DRD3_HUMAN	Homo sapiens	3	0.8358
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8357
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8354
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8350
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8349
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8345
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8334
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8329
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8300
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.8295
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8258
Repressor protein	Q7X0D9	Q7X0D9_ACIAD	Acinetobacter baylyi	3	0.8234
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8229
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8195
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8194
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.8181
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8150
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8143
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8143
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8114
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8109
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.8096
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8071
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8036
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8036
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8025
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	3	0.8007
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8003
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.7945
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7939
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7938
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.7877
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.7872
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7866
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7854
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.7836
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7831
rRNA methylase	Q8DSS3	Q8DSS3_STRMU	Streptococcus mutans serotype c	2	0.7825
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7816
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7814
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7790
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7761
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.7754
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7737
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	3	0.7725
Putative snRNP Sm-like protein	Q8ZYG5	Q8ZYG5_PYRAE	Pyrobaculum aerophilum	3	0.7700
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7695
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7693
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7686
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7677
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7663
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7645
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7644
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7641
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7614
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7607
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7602
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	3	0.7594
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7584
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.7574
Glutamate receptor 3	P19492	GRIA3_RAT	Rattus norvegicus	3	0.7572
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7571
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7561
mRNA cap guanine-N7 methyltransferase	O43148	MCES_HUMAN	Homo sapiens	3	0.7547
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7543
Beta-hexosaminidase	Q9KU37	NAGZ_VIBCH	Vibrio cholerae serotype O1	5	0.7542
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7531
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7530
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7530
Aminopeptidase N	P04825	AMPN_ECOLI	Escherichia coli	3	0.7527
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	4	0.7522
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7506
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7472
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7461
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7448
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7440
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7438
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7431
Formylmethanofuran--tetrahydromethanopterin formyltransferase	Q49610	FTR_METKA	Methanopyrus kandleri	3	0.7426
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	2	0.7424
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7424
Probable nicotinate-nucleotide adenylyltransferase	Q9HX21	NADD_PSEAE	Pseudomonas aeruginosa	3	0.7413
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7407
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7395
Poly(A) polymerase	P29468	PAP_YEAST	Saccharomyces cerevisiae	3	0.7394
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.7381
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7381
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7376
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7369
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7344
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7343
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7336
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7335
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7323
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7319
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7317
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7307
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7306
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7305
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7302
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7300
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7294
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	3	0.7291
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7286
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7284
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7281
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7281
Glycogen phosphorylase, liver form	P06737	PYGL_HUMAN	Homo sapiens	3	0.7274
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7264
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7254
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.7252
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7245
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7241
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7240
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7235
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7227
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7225
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7222
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7219
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.7218
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7212
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	4	0.7211
RNA-directed RNA polymerase	P11124	RDRP_BPPH6	Pseudomonas phage phi6	4	0.7208
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7199
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7195
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7189
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7188
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7182
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7172
Aminopeptidase N	P15145	AMPN_PIG	Sus scrofa	2	0.7171
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7168
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7163
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7153
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7152
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7152
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7150
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7146
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7139
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7133
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7124
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7124
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7124
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7119
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7116
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7114
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7113
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7107
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.7099
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7094
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7090
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7090
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7090
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7080
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	2	0.7078
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7078
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7075
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7075
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7070
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7054
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7052
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7051
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	2	0.7046
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7044
Genome polyprotein	P03303	POLG_HRV14	Human rhinovirus 14	3	0.7043
Dicamba O-demethylase, oxygenase component	Q5S3I3	DDMC_STEMA	Stenotrophomonas maltophilia	2	0.7038
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7038
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7034
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7029
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7029
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7024
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7023
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7021
GMP reductase	Q81JJ9	GUAC_BACAN	Bacillus anthracis	2	0.7011
4-hydroxyphenylpyruvate dioxygenase	P93836	HPPD_ARATH	Arabidopsis thaliana	3	0.7009
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7006
Gag-Pol polyprotein	P04587	POL_HV1B5	Human immunodeficiency virus type 1 group M subtype B	4	0.7005
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7005

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