ANPDB

Select a section from the left sidebar

10-hydroxyusambarine

Family: Plantae - Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indole Alkaloid

Canonical Smiles	C=C[C@H]1CN2CCc3c([C@@H]2C[C@@H]1C[C@@H]1N(C)CCc2c1[nH]c1c2cccc1)[nH]c1c3cc(cc1)O
InChI	InChI=1S/C30H34N4O/c1-3-18-17-34-13-11-23-24-16-20(35)8-9-26(24)32-30(23)28(34)15-19(18)14-27-29-22(10-12-33(27)2)21-6-4-5-7-25(21)31-29/h3-9,16,18-19,27-28,31-32,35H,1,10-15,17H2,2H3/t18-,19-,27-,28-/m0/s1
InChIKey	QYONROBEKPAESK-HVYZTVOGSA-N
Formula	C₃₀H₃₄N₄O
HBA	3
HBD	3
MW	466.63
Rotatable Bonds	3
TPSA	58.29
LogP	5.7
Number Rings	7
Number Aromatic Rings	4
Heavy Atom Count	35
Formal Charge	0
Fraction CSP3	0.4
Exact Mass	466.27
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 3084873

Cas: 42814-43-7

Gnps: CCMSLIB00004679917

Zinc: ZINC000058575611

Nmrshiftdb2: 70053774

Chembl: CHEMBL1213122

Comptox: DTXSID50195495

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C(NCC3)CC(C4)CCN(CC5)C4c(c5c67)[nH]c6cccc7

Level: 1

Mol. Weight: 466.63 g/mol

SMILES: C1CCCN(CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 466.63 g/mol

SMILES: C1CNCc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 466.63 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.64
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.63
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 0.55

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.83
Plasma Protein Binding: 89.75
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.41
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.5
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.19
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.52
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -1390.18
Rat (Acute): 2.58
Rat (Chronic Oral): 1.93
Fathead Minnow: 7.38
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 500.89
Hydration Free Energy: -3.0
Log(D) at pH=7.4: 4.56
Log(P): 4.89
Log S: -4.74
Log(Vapor Pressure): -9.53
Melting Point: 247.0
pKa Acid: 11.58
pKa Basic: 6.71

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9612
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9545
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9527
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.9457
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.9349
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9323
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9281
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.9226
Aklanonic acid methyl ester cyclase AcmA	O52646	DNRD_STRGJ	Streptomyces galilaeus	3	0.9083
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.9052
Alpha amylase	B8CZ54	B8CZ54_HALOH	Halothermothrix orenii	3	0.9006
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.8939
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8868
Naphthalene 1,2-dioxygenase system, large oxygenase component	P0A110	NDOB_PSEPU	Pseudomonas putida	3	0.8827
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8780
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8755
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.8734
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8718
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8708
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8665
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Q15750	TAB1_HUMAN	Homo sapiens	3	0.8656
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8608
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8564
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8553
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8526
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8492
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8484
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8446
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.8433
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8404
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8378
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8304
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	3	0.8244
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8240
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8230
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.8225
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8218
Beta-galactoside-specific lectin 1	P81446	ML1_VISAL	Viscum album	3	0.8209
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	3	0.8198
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8194
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8187
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	3	0.8175
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8126
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.8098
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.8097
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8090
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8070
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8070
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8042
Short form salivary protein D7R4	Q7PNF2	Q9BIH3_ANOGA	Anopheles gambiae	3	0.8039
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8030
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7991
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	3	0.7988
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7958
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7947
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7942
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7920
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7881
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7873
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	3	0.7871
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7864
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7808
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7785
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7776
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7765
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	4	0.7759
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7736
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7735
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7723
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7720
Integrin alpha-IIb	P08514	ITA2B_HUMAN	Homo sapiens	3	0.7720
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.7716
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7713
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7707
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7701
Aldose reductase-related protein 2	P45377	ALD2_MOUSE	Mus musculus	3	0.7699
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7698
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7674
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7669
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7662
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7659
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7655
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7635
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7631
mRNA cap guanine-N7 methyltransferase	O43148	MCES_HUMAN	Homo sapiens	3	0.7626
Adenosine 5'-monophosphoramidase HINT1	P49773	HINT1_HUMAN	Homo sapiens	3	0.7599
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7587
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7561
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	4	0.7544
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7537
Cyclic GMP-AMP synthase	Q8C6L5	CGAS_MOUSE	Mus musculus	3	0.7527
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7512
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7510
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7509
Envelope glycoprotein gp160	Q0ED31	Q0ED31_9HIV1	Human immunodeficiency virus 1	4	0.7460
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7459
Botulinum neurotoxin type B	P10844	BXB_CLOBO	Clostridium botulinum	4	0.7437
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7435
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7432
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7423
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7420
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7414
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7407
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7407
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7401
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7396
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7394
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7392
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7372
Genome polyprotein	P03303	POLG_HRV14	Human rhinovirus 14	3	0.7371
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7370
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7368
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7359
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7355
Cyclic nucleotide-gated potassium channel mll3241	Q98GN8	CNGK1_RHILO	Mesorhizobium japonicum)	3	0.7355
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7351
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7348
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7346
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7344
Phosphoglycerate kinase 1	P00558	PGK1_HUMAN	Homo sapiens	3	0.7344
HD domain protein	Q836G9	Q836G9_ENTFA	Enterococcus faecalis	3	0.7343
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7340
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7339
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7336
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7335
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7329
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7325
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7321
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7302
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7299
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7299
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7296
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7284
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.7284
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7277
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7277
Endoplasmic reticulum aminopeptidase 2	Q6P179	ERAP2_HUMAN	Homo sapiens	3	0.7274
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7273
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7273
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7270
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7262
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7262
cAMP-activated global transcriptional regulator Vfr	P55222	VFR_PSEAE	Pseudomonas aeruginosa	3	0.7260
Formylmethanofuran--tetrahydromethanopterin formyltransferase	Q49610	FTR_METKA	Methanopyrus kandleri	3	0.7259
Cobalt-precorrin-4 C(11)-methyltransferase	O87696	CBIF_BACME	Priestia megaterium	3	0.7256
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7247
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7243
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	4	0.7240
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.7225
Mevalonate kinase	P17256	KIME_RAT	Rattus norvegicus	3	0.7224
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7215
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	4	0.7212
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7212
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7212
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7209
Phosphoglycerate kinase	Q83AU6	PGK_COXBU	Coxiella burnetii	3	0.7209
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7205
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7200
Polyamine oxidase FMS1	P50264	FMS1_YEAST	Saccharomyces cerevisiae	3	0.7191
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7189
Poly [ADP-ribose] polymerase 1	P26446	PARP1_CHICK	Gallus gallus	3	0.7184
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7184
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	2	0.7181
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7178
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	O88704	HCN1_MOUSE	Mus musculus	3	0.7167
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7164
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7163
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7161
Serine/threonine-protein kinase RAD53	P22216	RAD53_YEAST	Saccharomyces cerevisiae	4	0.7152
rRNA methylase	Q8DSS3	Q8DSS3_STRMU	Streptococcus mutans serotype c	2	0.7150
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7143
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7136
Histone-lysine N-methyltransferase EHMT2	Q96KQ7	EHMT2_HUMAN	Homo sapiens	3	0.7128
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7128
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7126
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7123
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7119
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7117
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7111
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7102
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7102
Chaperone protein ClpB	Q9RA63	CLPB_THET8	Thermus thermophilus	3	0.7102
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7098
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	3	0.7088
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7088
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7086
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7074
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7070
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7063
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7058
(R)-S-adenosyl-L-methionine hydrolase	O58212	O58212_PYRHO	Pyrococcus horikoshii OT3	3	0.7057
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7053
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7049
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7045
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7045
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7044
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	4	0.7040
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7040
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7039
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	3	0.7037
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	2	0.7033
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7031
Rho-associated protein kinase 1	Q13464	ROCK1_HUMAN	Homo sapiens	3	0.7029
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7029
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7027
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7020
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7016
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7015
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7015
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.7014
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7012
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7011
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7011
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7007

Download SDF