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11-hydroxyusambarine

Family: Loganiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Indole Alkaloid

Canonical Smiles	C=C[C@H]1CN2CCc3c([C@@H]2C[C@@H]1C[C@@H]1N(C)CCc2c1[nH]c1c2cccc1)[nH]c1c3ccc(c1)O
InChI	InChI=1S/C30H34N4O/c1-3-18-17-34-13-11-24-22-9-8-20(35)16-26(22)32-30(24)28(34)15-19(18)14-27-29-23(10-12-33(27)2)21-6-4-5-7-25(21)31-29/h3-9,16,18-19,27-28,31-32,35H,1,10-15,17H2,2H3/t18-,19-,27-,28-/m0/s1
InChIKey	DGQWMSVZRIPJMR-HVYZTVOGSA-N
Formula	C₃₀H₃₄N₄O
HBA	3
HBD	3
MW	466.63
Rotatable Bonds	3
TPSA	58.29
LogP	5.7
Number Rings	7
Number Aromatic Rings	4
Heavy Atom Count	35
Formal Charge	0
Fraction CSP3	0.4
Exact Mass	466.27
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Strychnos usambarensis	Loganiaceae	Plantae	992791

Showing of synonyms

Frederich M, Hayette MP, et al. (1999). In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum.. Antimicrobial agents and chemotherapy,1999, 43(9), 2328-31. [View] [PubMed]

Pubchem: 401427

Gnps: CCMSLIB00004679918

Zinc: ZINC000006040346

Nmrshiftdb2: 70053772

Chembl: CHEMBL1213172

No compound-protein relationship available.

SMILES: c1cccc2[nH]c(c3c12)C(NCC3)CC(C4)CCN(CC5)C4c(c5c67)[nH]c6cccc7

Level: 1

Mol. Weight: 410.57 g/mol

SMILES: C1CCCN(CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 226.32 g/mol

SMILES: C1CNCc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 172.23 g/mol

Antimalarial

Absorption

Caco-2 (logPapp): -5.63
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.65
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 0.42

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.8
Plasma Protein Binding: 89.2
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.58
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.52
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1.25
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.51
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -1382.36
Rat (Acute): 2.59
Rat (Chronic Oral): 1.98
Fathead Minnow: 7.39
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 500.23
Hydration Free Energy: -3.0
Log(D) at pH=7.4: 4.54
Log(P): 5.05
Log S: -4.75
Log(Vapor Pressure): -9.5
Melting Point: 247.06
pKa Acid: 11.4
pKa Basic: 6.72

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9624
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9601
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9559
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9451
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9448
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.9390
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.9362
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.9351
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9349
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.9313
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	3	0.9199
Death-associated protein kinase 3	O43293	DAPK3_HUMAN	Homo sapiens	3	0.9164
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9139
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9110
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9073
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.9065
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9056
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.9032
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.9012
Aklanonic acid methyl ester cyclase AcmA	O52646	DNRD_STRGJ	Streptomyces galilaeus	3	0.8986
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8976
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8961
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8942
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8934
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.8870
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8834
Short form salivary protein D7R4	Q7PNF2	Q9BIH3_ANOGA	Anopheles gambiae	3	0.8782
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8776
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8759
Naphthalene 1,2-dioxygenase system, large oxygenase component	P0A110	NDOB_PSEPU	Pseudomonas putida	3	0.8740
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8722
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8702
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8691
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8650
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8646
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8613
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8610
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8603
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8583
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.8581
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8567
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8545
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8532
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Q15750	TAB1_HUMAN	Homo sapiens	3	0.8526
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8523
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.8511
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8502
Cobalt-precorrin-4 C(11)-methyltransferase	O87696	CBIF_BACME	Priestia megaterium	3	0.8485
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8392
RAC-alpha serine/threonine-protein kinase	P31749	AKT1_HUMAN	Homo sapiens	3	0.8349
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.8310
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8294
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8277
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8270
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8241
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	3	0.8194
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	3	0.8167
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.8158
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	3	0.8122
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8102
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.8089
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8075
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8056
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8054
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8047
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	3	0.8045
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8044
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7998
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.7992
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7981
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7966
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7960
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7933
Cholesterol 24-hydroxylase	Q9Y6A2	CP46A_HUMAN	Homo sapiens	3	0.7910
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7895
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7883
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7880
Integrin alpha-IIb	P08514	ITA2B_HUMAN	Homo sapiens	3	0.7859
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7847
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7847
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7807
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7803
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7797
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7789
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7780
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7778
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7753
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	3	0.7744
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7740
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7722
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7710
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7683
Aldose reductase-related protein 2	P45377	ALD2_MOUSE	Mus musculus	3	0.7680
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7664
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7626
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7614
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7613
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7605
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7583
mRNA cap guanine-N7 methyltransferase	O43148	MCES_HUMAN	Homo sapiens	3	0.7576
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7549
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.7545
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7538
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7519
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7495
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	3	0.7487
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7487
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7482
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.7466
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7463
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7461
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7457
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7436
Envelope glycoprotein gp160	Q0ED31	Q0ED31_9HIV1	Human immunodeficiency virus 1	4	0.7434
cAMP-activated global transcriptional regulator Vfr	P55222	VFR_PSEAE	Pseudomonas aeruginosa	3	0.7429
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7428
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7423
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7423
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7411
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7411
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7396
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7377
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.7368
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7365
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7360
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7360
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7348
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7346
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7335
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7326
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7323
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7323
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7320
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7305
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7301
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	3	0.7298
histidine kinase	Q9WZV7	Q9WZV7_THEMA	Thermotoga maritima	3	0.7294
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7292
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7288
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7287
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7286
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7281
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7279
Adenosine 5'-monophosphoramidase HINT1	P49773	HINT1_HUMAN	Homo sapiens	3	0.7276
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7275
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7267
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7267
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7264
Cytokinin dehydrogenase 1	Q9T0N8	CKX1_MAIZE	Zea mays	4	0.7262
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7258
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7258
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7255
tRNA (cytidine(34)-2'-O)-methyltransferase	P44868	TRML_HAEIN	Haemophilus influenzae	3	0.7254
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7251
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7249
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7248
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7244
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7241
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7240
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7229
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7228
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7228
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7222
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.7221
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7213
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7212
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7211
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7210
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7209
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7208
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7206
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7204
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7203
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7198
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7195
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7194
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7188
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7182
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7182
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	3	0.7180
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7166
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7165
Chaperone protein ClpB	Q9RA63	CLPB_THET8	Thermus thermophilus	3	0.7165
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7164
Cyclic nucleotide-binding domain-containing protein	E0RR11	E0RR11_SPITD	Spirochaeta thermophila	3	0.7164
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7159
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7155
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7143
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7142
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7141
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7132
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7128
GMP reductase	Q81JJ9	GUAC_BACAN	Bacillus anthracis	2	0.7127
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7126
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.7124
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7120
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7117
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	4	0.7110
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	3	0.7104
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7095
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7089
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7086
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7078
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7069
Histone-lysine N-methyltransferase EHMT2	Q96KQ7	EHMT2_HUMAN	Homo sapiens	3	0.7065
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7065
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7064
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7051
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7049
UDP-N-acetylenolpyruvoylglucosamine reductase	P08373	MURB_ECOLI	Escherichia coli	3	0.7038
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	2	0.7030
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7028
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7027
Cytosolic heat shock protein 90	Q7XJ80	Q7XJ80_HORVU	Hordeum vulgare	3	0.7025
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7025
Cobalamin synthesis related protein	Q6NIF5	Q6NIF5_CORDI	Corynebacterium diphtheriae	3	0.7024
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7022
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7020
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7019
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7018
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7017
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7014
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7008
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7005
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	3	0.7004

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