Holstiichalcone II - Compound Card

Holstiichalcone II

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Holstiichalcone II

Structure
Zoomed Structure
  • Family: Ochnaceae
  • Kingdom: Plantae
  • Class: Chalcone
    • Subclass: Bichalcone
Canonical Smiles Oc1ccc(c(c1)O)C(=O)/C=C/c1ccc(c(c1)c1cc(/C=C/C(=O)c2ccc(cc2O)O)ccc1O)O
InChI InChI=1S/C30H22O8/c31-19-5-7-21(29(37)15-19)25(33)9-1-17-3-11-27(35)23(13-17)24-14-18(4-12-28(24)36)2-10-26(34)22-8-6-20(32)16-30(22)38/h1-16,31-32,35-38H/b9-1+,10-2+
InChIKey SZXMCHCNKAGQRE-UVEKSMONSA-N
Formula C30H22O8
HBA 8
HBD 6
MW 510.5
Rotatable Bonds 7
TPSA 155.52
LogP 5.38
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 38
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 510.13
Number of Lipinski Rule Violations 3
# Species Family Kingdom NCBI Taxonomy ID
1 Ochna holstii Ochnaceae Plantae 1389766

Showing of synonyms

  • Kalenga TM, Ndoile MM, et al. (2021). Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii. Journal of natural products,2021, 84(2), 364-372. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2cc(ccc2)-c(ccc3)cc3C=CC(=O)c4ccccc4

Level: 3

Mol. Weight: 414.5 g/mol

Structure

SMILES: c1ccccc1C(=O)C=Cc2cc(ccc2)-c3ccccc3

Level: 2

Mol. Weight: 284.36 g/mol

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 208.26 g/mol

Structure

SMILES: c1ccccc1-c2ccccc2

Level: 1

Mol. Weight: 154.21 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.83
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.100
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
0.54

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.130
Plasma Protein Binding
86.1
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.880
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.570
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.570
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.770
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-1309.220
Rat (Acute)
2.280
Rat (Chronic Oral)
3.800
Fathead Minnow
8.870
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
641.360
Hydration Free Energy
-3.100
Log(D) at pH=7.4
3.450
Log(P)
5.07
Log S
-7.25
Log(Vapor Pressure)
-10.83
Melting Point
311.0
pKa Acid
6.02
pKa Basic
9.78
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9613
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9553
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9409
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9364
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9362
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9349
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9334
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9330
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9275
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9266
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9226
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9189
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9184
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9132
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.9130
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9119
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9102
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9051
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.9023
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9001
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.9001
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8992
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8889
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8862
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.8854
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8837
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8833
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8795
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.8794
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8763
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 4 0.8762
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8762
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8759
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8749
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8749
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8724
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8706
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8685
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8644
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8639
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 4 0.8634
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8631
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8612
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8581
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8576
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8564
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8556
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8550
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8543
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8495
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8484
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8476
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8476
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.8452
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8439
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8436
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8423
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8396
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8383
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8364
Nociceptin receptor P41146 OPRX_HUMAN Homo sapiens 3 0.8324
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8324
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8315
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8312
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8287
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.8278
Tyrosyl-DNA phosphodiesterase 2 Q9JJX7 TYDP2_MOUSE Mus musculus 3 0.8278
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8254
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8241
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8200
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.8199
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8183
Cathepsin S P25774 CATS_HUMAN Homo sapiens 4 0.8177
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8164
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8162
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.8146
p-hydroxybenzoate hydroxylase P00438 PHHY_PSEFL Pseudomonas fluorescens 3 0.8143
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8138
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8126
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8103
Regucalcin Q64374 RGN_MOUSE Mus musculus 3 0.8101
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8096
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8082
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8082
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8079
N-acylamino acid racemase Q9RYA6 Q9RYA6_DEIRA Deinococcus radiodurans 3 0.8045
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8028
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8020
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8016
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7986
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7968
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7960
Cytochrome P450 107B1 A0R5U2 A0R5U2_MYCS2 Mycolicibacterium smegmatis155) 3 0.7956
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7946
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 3 0.7928
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7927
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7901
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7898
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7898
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7897
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7887
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7876
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7868
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7835
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7829
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7828
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7818
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7817
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7815
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7807
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7804
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7782
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7779
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7776
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7749
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7746
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7740
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7739
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7738
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7738
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7737
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7731
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7722
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7713
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7688
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7677
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7676
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7675
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7673
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7673
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7672
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7663
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7659
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7644
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7633
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7633
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7628
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7628
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7627
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7620
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7620
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7610
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7608
Tyrosine-protein kinase ABL1 P00520 ABL1_MOUSE Mus musculus 4 0.7595
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7590
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7585
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7583
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 3 0.7583
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7576
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7565
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7561
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7557
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.7523
Flagellum-specific ATP synthase P26465 FLII_SALTY Salmonella typhimurium 2 0.7520
Antiviral protein I P10297 RIP1_PHYAM Phytolacca americana 4 0.7517
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7514
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7502
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7502
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7500
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7490
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7483
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7482
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 4 0.7481
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7477
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7475
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7468
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7466
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7455
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7453
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7451
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7447
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7445
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7444
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7443
Probable nicotinate-nucleotide adenylyltransferase C3L5T6 NADD_BACAC Bacillus anthracis 3 0.7439
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7437
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7432
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7419
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 4 0.7413
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7411
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7410
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7410
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7409
O-GlcNAcase BT_4395 Q89ZI2 OGA_BACTN Bacteroides thetaiotaomicron 4 0.7408
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7404
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7404
Dual specificity protein kinase TTK P33981 TTK_HUMAN Homo sapiens 4 0.7393
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7392
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7391
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7390
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7387
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7380
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7379
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7377
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7373
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7370
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7369
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7368
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7362
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7359
Dual specificity protein kinase TTK P33981 TTK_HUMAN Homo sapiens 3 0.7355
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7355
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7348
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7345
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7344
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 2 0.7340
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7326
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7320
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7318
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7315
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7315
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7314
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7313
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7312
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7311
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7306
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7305
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7304
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7300
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7299
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7299
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7299
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7295
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7294
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7293
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7292
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7288
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7285
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 4 0.7281
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7277
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7277
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7276
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7267
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7266
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7266
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7261
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7260
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7254
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7249
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7245
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7244
Dual specificity protein kinase TTK P33981 TTK_HUMAN Homo sapiens 4 0.7242
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7241
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7237
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7237
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7236
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7233
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7227
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7214
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7211
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7209
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7208
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 2 0.7205
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7204
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7202
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7201
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7199
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7191
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7186
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7183
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7182
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7180
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7180
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7174
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7173
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7169
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7166
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 3 0.7164
Acetyltransferase YpeA P76539 YPEA_ECOLI Escherichia coli 3 0.7164
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7155
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7151
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7151
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 5 0.7149
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 4 0.7146
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7142
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7141
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7136
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7130
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7128
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7127
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7125
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7124
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7122
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7120
Integrin alpha-5 P08648 ITA5_HUMAN Homo sapiens 3 0.7116
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7113
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7112
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7112
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7110
BH2602 protein Q9K9P3 Q9K9P3_BACHD Bacillus halodurans 3 0.7109
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7103
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7102
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7100
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7099
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7098
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7095
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7090
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7087
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7084
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7082
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7076
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7076
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7075
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7075
Dual specificity protein kinase TTK P33981 TTK_HUMAN Homo sapiens 4 0.7074
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7073
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7071
Histone demethylase UTY O14607 UTY_HUMAN Homo sapiens 3 0.7067
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7067
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7065
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7060
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7059
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7058
Casein kinase I isoform gamma-2 P78368 KC1G2_HUMAN Homo sapiens 3 0.7051
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7050
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.7049
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7048
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7046
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7044
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7037
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7035
Unconventional myosin-Va Q02440 MYO5A_CHICK Gallus gallus 2 0.7030
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7027
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7027
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7024
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7022
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7020
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7017
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7016
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7014
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7013
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7013
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7010
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7007
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7006
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7006
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7004
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7003
Interleukin enhancer-binding factor 2 Q9CXY6 ILF2_MOUSE Mus musculus 2 0.7003
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7002
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7001

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