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Terminalionone

Family: Plantae - Ochnaceae
Kingdom: Plantae
Class: Chalcone

Canonical Smiles	Oc1ccc(cc1)C(=O)Cc1coc2c(c1=O)ccc(c2)O
InChI	InChI=1S/C17H12O5/c18-12-3-1-10(2-4-12)15(20)7-11-9-22-16-8-13(19)5-6-14(16)17(11)21/h1-6,8-9,18-19H,7H2
InChIKey	JYGFYKDDIOAEHU-UHFFFAOYSA-N
Formula	C₁₇H₁₂O₅
HBA	5
HBD	2
MW	296.28
Rotatable Bonds	3
TPSA	87.74
LogP	2.63
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	22
Formal Charge	0
Fraction CSP3	0.06
Exact Mass	296.07
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ochna holstii	Ochnaceae	Plantae	1389766

Showing of synonyms

Kalenga TM, Ndoile MM, et al. (2021). Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii. Journal of natural products,2021, 84(2), 364-372. [View] [PubMed]

Pubchem: 23652104

Zinc: ZINC000140846257

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)Cc(c2=O)coc(c23)cccc3

Level: 1

Mol. Weight: 296.28 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 296.28 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 296.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.8
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.770
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.76

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.140
Plasma Protein Binding: 76.5
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 4.520
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.960
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.160
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.010
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Toxic
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.180
Rat (Acute): 2.090
Rat (Chronic Oral): 2.190
Fathead Minnow: 4.570
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 469.280
Hydration Free Energy: -11.710
Log(D) at pH=7.4: 2.150
Log(P): 2.61
Log S: -4.73
Log(Vapor Pressure): -9.91
Melting Point: 296.22
pKa Acid: 7.09
pKa Basic: 6.16

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9661
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9636
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.9596
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9542
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9519
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9474
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9438
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9438
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9339
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.9319
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9256
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9185
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9151
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.9134
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.9132
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9124
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9116
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.9105
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9100
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.9092
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9091
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9086
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9083
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.9032
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.9016
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.9008
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.8977
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8929
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8904
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8898
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.8870
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8863
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8855
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8846
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8826
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8818
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8777
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8742
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8698
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8647
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8638
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8632
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8616
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8613
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8601
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8594
Albumin	P02768	ALBU_HUMAN	Homo sapiens	4	0.8554
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8522
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8506
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8469
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8464
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8450
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8450
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8405
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8399
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8364
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.8360
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	4	0.8355
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	3	0.8336
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.8336
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8324
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8313
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8300
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8292
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.8291
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8289
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	5	0.8274
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8273
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8269
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8255
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8240
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8229
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8222
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8220
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8214
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8199
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.8193
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.8164
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8162
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8151
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8144
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8141
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.8122
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8107
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8097
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8089
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8049
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8047
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8035
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8032
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8029
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8028
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	3	0.8027
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.8027
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8020
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.8013
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8011
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8007
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7999
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.7996
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7978
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.7943
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7930
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7930
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7925
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7914
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7909
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7887
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7874
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7857
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7846
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7836
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7831
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7823
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7814
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7808
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7804
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	3	0.7801
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	4	0.7796
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7794
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7789
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7779
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7779
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7772
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7772
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7771
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7768
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.7765
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7762
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7752
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7750
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7741
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7733
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7731
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7725
Enoyl-acyl carrier reductase	C6KSZ2	C6KSZ2_PLAF7	Plasmodium falciparum	4	0.7708
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7693
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7673
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7672
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7665
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.7655
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7646
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7646
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7644
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7642
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7639
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	4	0.7628
3',5'-cyclic-AMP phosphodiesterase 4A	P27815	PDE4A_HUMAN	Homo sapiens	3	0.7628
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7624
Botulinum neurotoxin type B	P10844	BXB_CLOBO	Clostridium botulinum	3	0.7622
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.7619
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7619
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7618
Bifunctional dihydrofolate reductase-thymidylate synthase	Q27793	DRTS_TRYCR	Trypanosoma cruzi	3	0.7616
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7613
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7610
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7608
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7605
Dihydrofolate reductase type 1 from Tn4003	P13955	DYRA_STAAU	Staphylococcus aureus	3	0.7597
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	3	0.7591
Heat shock protein 75 kDa, mitochondrial	Q12931	TRAP1_HUMAN	Homo sapiens	3	0.7589
Bifunctional dihydrofolate reductase-thymidylate synthase	Q07422	DRTS_TOXGO	Toxoplasma gondii	3	0.7583
Cytochrome P450 2C8	P10632	CP2C8_HUMAN	Homo sapiens	3	0.7575
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7575
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7574
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7572
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7568
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7567
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7564
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7562
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	3	0.7561
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7558
Thymidylate synthase ThyA	P9WFR9	TYSY_MYCTU	Mycobacterium tuberculosis	3	0.7555
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7551
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7549
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7533
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7532
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7521
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7520
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7512
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7512
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7510
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7508
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7505
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	4	0.7493
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7490
Glutamine synthetase	P9WN39	GLN1B_MYCTU	Mycobacterium tuberculosis	3	0.7490
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7485
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7482
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7478
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7470
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	4	0.7469
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7462
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7461
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7461
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7458
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7456
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7455
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7453
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7449
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7446
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7441
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7438
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7429
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7428
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7422
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7422
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	4	0.7420
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8ZMF7	ISPF_SALTY	Salmonella typhimurium	3	0.7420
Dihydrofolate reductase	Q83AB2	Q83AB2_COXBU	Coxiella burnetii	3	0.7417
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7416
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7412
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7411
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7410
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7408
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	4	0.7402
Virulence sensor histidine kinase PhoQ	P0DM80	PHOQ_SALTY	Salmonella typhimurium	3	0.7397
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7394
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7392
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7390
Dihydrofolate reductase	O30463	O30463_MYCAV	Mycobacterium avium	3	0.7383
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7381
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7380
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7380
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	3	0.7379
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7375
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7368
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7363
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7363
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7363
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7361
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7361
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7360
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7360
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.7357
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7354
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7347
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7342
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7338
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7335
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7328
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7316
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7316
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7316
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7315
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7309
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7306
Clathrin heavy chain 1	Q00610	CLH1_HUMAN	Homo sapiens	3	0.7303
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7303
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7301
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7300
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7299
O-GlcNAcase NagJ	Q0TR53	OGA_CLOP1	Clostridium perfringens	3	0.7299
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7299
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7298
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7296
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7296
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7289
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7284
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7281
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7280
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7278
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7276
Putative N-acetyl glucosaminyl transferase	Q6U8B0	Q6U8B0_RAOTE	Raoultella terrigena	3	0.7272
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7271
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.7270
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7270
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7266
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7266
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7264
Carbonic anhydrase 4	P22748	CAH4_HUMAN	Homo sapiens	3	0.7261
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7260
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7256
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7253
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7252
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7247
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7246
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7243
Dihydrofolate reductase	Q81R22	Q81R22_BACAN	Bacillus anthracis	3	0.7241
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7240
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7239
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7235
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase	Q6T1W8	FDTA_ANETH	Aneurinibacillus thermoaerophilus	3	0.7232
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7231
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7227
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	4	0.7227
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7225
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7222
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7220
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7217
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	4	0.7214
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7211
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7209
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7207
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7206
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7204
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	3	0.7202
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.7202
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	4	0.7200
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8RQP5	ISPF_THET8	Thermus thermophilus	3	0.7197
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7189
Beta-lactamase	Q79MP6	Q79MP6_PSEAI	Pseudomonas aeruginosa	2	0.7188
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7184
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7170
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7170
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7168
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7166
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7164
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7158
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7148
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	3	0.7148
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7146
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7141
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7139
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7138
Cytochrome P450 2C19	P33261	CP2CJ_HUMAN	Homo sapiens	3	0.7136
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7135
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7133
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7132
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7130
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7130
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7129
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7128
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7124
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7123
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7117
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7116
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7116
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7113
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7111
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q08210	PYRD_PLAF7	Plasmodium falciparum	3	0.7106
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7106
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	2	0.7103
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7101
Cytidylate kinase	Q5SL35	KCY_THET8	Thermus thermophilus	3	0.7089
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7089
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7088
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7087
Dihydrofolate reductase	Q81R22	Q81R22_BACAN	Bacillus anthracis	3	0.7086
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7085
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7079
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7077
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7077
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7076
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7075
Retinoic acid receptor gamma	P13631	RARG_HUMAN	Homo sapiens	3	0.7073
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7073
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7068
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	3	0.7063
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7060
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7059
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7055
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7054
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7051
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7046
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7044
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	4	0.7042
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	3	0.7038
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7038
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7038
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7032
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7027
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7027
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7027
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	4	0.7023
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7023
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7023
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7022
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7017
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7016
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7014
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	2	0.7012
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7011
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7009
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7008
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7003
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7000

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