ANPDB

Select a section from the left sidebar

3-hydroxy-5-methoxybiphenyl

Family: Plantae - Polygalaceae
Kingdom: Plantae
Class: Benzenoid
- Subclass: Benzophenone

Canonical Smiles	COc1cc(O)cc(c1)c1ccccc1
InChI	InChI=1S/C13H12O2/c1-15-13-8-11(7-12(14)9-13)10-5-3-2-4-6-10/h2-9,14H,1H3
InChIKey	MFGGGJCBWVBPEO-UHFFFAOYSA-N
Formula	C₁₃H₁₂O₂
HBA	2
HBD	1
MW	200.24
Rotatable Bonds	2
TPSA	29.46
LogP	3.07
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	15
Formal Charge	0
Fraction CSP3	0.08
Exact Mass	200.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Securidaca longipedunculata	Polygalaceae	Plantae	690845

Showing of synonyms

Ochora DO, Kakudidi E, et al. (2022). A new benzophenone, and the Antiplasmodial activities of the constituents of Securidaca longipedunculata fresen (Polygalaceae). Natural product research,2022, 36(11), 2758-2766. [View] [PubMed]

Pubchem: 12000323

Cas: 55814-99-8

Zinc: ZINC000013377036

Chebi: 70633

Nmrshiftdb2: 20180795

Metabolights: MTBLC70633

Chembl: CHEMBL470237

Comptox: DTXSID70475564

No compound-protein relationship available.

SMILES: c1ccccc1-c2ccccc2

Level: 1

Mol. Weight: 200.24 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 200.24 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.61
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.160
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.18

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.830
Plasma Protein Binding: 58.64
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.610
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 2.080
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.050
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.040
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.720
Rat (Acute): 1.750
Rat (Chronic Oral): 2.290
Fathead Minnow: 4.420
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 315.820
Hydration Free Energy: -7.850
Log(D) at pH=7.4: 3.400
Log(P): 3.38
Log S: -3.75
Log(Vapor Pressure): -4.69
Melting Point: 92.07
pKa Acid: 9.97
pKa Basic: 1.65

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9853
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9740
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.9729
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.9634
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.9489
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9469
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9455
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.9445
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9440
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9437
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9413
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.9384
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9323
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9309
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9292
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9288
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.9233
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9217
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9214
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.9184
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.9137
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.9113
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9094
Biphenyl-2,3-diol 1,2-dioxygenase	P47228	BPHC_PARXL	Paraburkholderia xenovorans	3	0.9090
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.9089
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9081
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.9054
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8997
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8996
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8974
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.8835
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8804
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.8779
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8772
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.8737
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8725
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.8710
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.8709
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8688
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8661
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8652
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q3JRA0	ISPF_BURP1	Burkholderia pseudomallei	4	0.8638
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8624
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8592
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	3	0.8423
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.8410
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.8361
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8356
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8344
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8340
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.8272
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8213
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.8199
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8198
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8160
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8156
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	3	0.8130
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	3	0.8120
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8091
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.8076
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8033
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8032
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8001
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7990
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7971
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7964
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7963
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	2	0.7954
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7947
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7931
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7906
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7905
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7897
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	2	0.7888
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7882
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7880
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7875
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7874
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7872
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7813
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7789
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7777
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7769
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	2	0.7767
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	2	0.7744
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7737
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7725
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7712
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7698
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	3	0.7684
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7674
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7663
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7661
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7660
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7647
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7646
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7644
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7632
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7629
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7624
cGMP-dependent protein kinase, putative	A5K0N4	A5K0N4_PLAVS	Plasmodium vivax	3	0.7622
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7622
Endoplasmin	P14625	ENPL_HUMAN	Homo sapiens	3	0.7620
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7619
Septum site-determining protein MinD	P0AEZ3	MIND_ECOLI	Escherichia coli	3	0.7618
Rac-like GTP-binding protein ARAC7	O82480	RAC7_ARATH	Arabidopsis thaliana	3	0.7617
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7609
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7603
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7603
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.7599
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7595
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	3	0.7588
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7587
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7584
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7584
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7582
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7581
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7580
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7578
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7577
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7577
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7573
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7570
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7562
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7553
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7546
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7537
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7535
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7531
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.7530
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7522
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7516
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7507
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7507
Dihydrofolate reductase	O30463	O30463_MYCAV	Mycobacterium avium	3	0.7497
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7497
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7495
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7490
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	Q08AH3	ACS2A_HUMAN	Homo sapiens	2	0.7479
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7472
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7472
Dihydrofolate reductase	Q83AB2	Q83AB2_COXBU	Coxiella burnetii	3	0.7470
Gibberellin receptor GID1	Q6L545	GID1_ORYSJ	Oryza sativa subsp. japonica	3	0.7451
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7451
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7448
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7444
Androgen receptor	P19091	ANDR_MOUSE	Mus musculus	3	0.7443
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7441
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7441
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	2	0.7441
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7440
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7436
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7428
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7427
NPC intracellular cholesterol transporter 1	O15118	NPC1_HUMAN	Homo sapiens	2	0.7427
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7426
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7421
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7417
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7413
Gibberellin receptor GID1A	Q9MAA7	GID1A_ARATH	Arabidopsis thaliana	3	0.7411
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7406
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7401
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7401
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7400
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	2	0.7398
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	2	0.7397
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7396
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7391
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7390
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7389
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7385
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7385
Sepiapterin reductase	Q64105	SPRE_MOUSE	Mus musculus	3	0.7383
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7381
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7379
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7379
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	2	0.7375
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7373
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7373
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7371
3',5'-cyclic-AMP phosphodiesterase 4A	P27815	PDE4A_HUMAN	Homo sapiens	3	0.7367
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	3	0.7361
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7361
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	2	0.7358
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7354
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7352
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7340
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7336
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7335
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7332
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7328
Farnesyl pyrophosphate synthase	P14324	FPPS_HUMAN	Homo sapiens	2	0.7328
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7327
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7327
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	2	0.7324
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7316
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7312
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	2	0.7311
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7309
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7309
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7308
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	2	0.7303
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7303
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7301
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7298
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7298
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7298
Cytochrome P450 2C9	P11712	CP2C9_HUMAN	Homo sapiens	2	0.7291
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7287
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	3	0.7286
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7281
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7281
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7279
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7279
Fatty acid-binding protein, adipocyte	P04117	FABP4_MOUSE	Mus musculus	2	0.7279
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7277
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7269
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7262
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7261
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7260
Dihydrofolate reductase	Q81R22	Q81R22_BACAN	Bacillus anthracis	3	0.7258
Dihydrofolate reductase	Q81R22	Q81R22_BACAN	Bacillus anthracis	3	0.7257
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7255
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7252
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7247
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	2	0.7247
Dihydrofolate reductase	Q81R22	Q81R22_BACAN	Bacillus anthracis	3	0.7244
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7243
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7231
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7227
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7226
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7223
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7222
Pentalenic acid synthase	Q825I8	CYP28_STRAW	Streptomyces avermitilis	2	0.7218
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7217
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7212
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7209
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7207
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7204
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7203
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	2	0.7202
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7201
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7197
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7192
Glutamate receptor 2	P42262	GRIA2_HUMAN	Homo sapiens	2	0.7190
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	2	0.7183
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7180
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7174
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.7172
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7167
GTPase IMAP family member 2	Q9UG22	GIMA2_HUMAN	Homo sapiens	3	0.7166
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7165
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	2	0.7161
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	2	0.7160
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7157
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7152
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	2	0.7152
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7150
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7147
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	2	0.7145
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7144
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7142
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7138
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7135
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7131
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	2	0.7128
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7126
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7124
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	3	0.7123
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7123
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	2	0.7115
Terminal oxygenase component of carbazole	Q84II6	Q84II6_JANS3	Janthinobacterium sp	2	0.7113
Androgen receptor	O97775	ANDR_PANTR	Pan troglodytes	3	0.7108
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7107
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7101
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7097
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7093
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7092
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7092
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	2	0.7091
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7090
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	2	0.7090
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	2	0.7089
Protoporphyrinogen oxidase, mitochondrial	O24164	PPOM_TOBAC	Nicotiana tabacum	2	0.7086
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7086
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7086
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7085
Aurora kinase B-A	Q6DE08	AUKBA_XENLA	Xenopus laevis	3	0.7082
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7077
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7075
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7071
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7064
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	2	0.7052
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7051
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7045
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7034
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7030
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7029
Cytosolic IMP-GMP specific 5'-nucleotidase	Q5ZZB6	Q5ZZB6_LEGPH	Legionella pneumophila subsp. pneumophila	3	0.7024
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	2	0.7021
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7018
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7016
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7015
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7012
3-dehydroquinate dehydratase	P9WPX7	AROQ_MYCTU	Mycobacterium tuberculosis	2	0.7011
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7010
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7010
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7009
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7009
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	2	0.7008
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7004
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	2	0.7004
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7001
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7001

Download SDF