2,4,5-trimethoxybenzophenone - Compound Card

2,4,5-trimethoxybenzophenone

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2,4,5-trimethoxybenzophenone

Structure
Zoomed Structure
  • Family: Plantae - Polygalaceae
  • Kingdom: Plantae
  • Class: Benzenoid
    • Subclass: Benzophenone
Canonical Smiles COc1cc(OC)c(cc1C(=O)c1ccccc1)OC
InChI InChI=1S/C16H16O4/c1-18-13-10-15(20-3)14(19-2)9-12(13)16(17)11-7-5-4-6-8-11/h4-10H,1-3H3
InChIKey CWXBRVFPEIGVSF-UHFFFAOYSA-N
Formula C16H16O4
HBA 4
HBD 0
MW 272.3
Rotatable Bonds 5
TPSA 44.76
LogP 2.94
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 272.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Securidaca longipedunculata Polygalaceae Plantae 690845

Showing of synonyms

  • Ochora DO, Kakudidi E, et al. (2022). A new benzophenone, and the Antiplasmodial activities of the constituents of Securidaca longipedunculata fresen (Polygalaceae). Natural product research,2022, 36(11), 2758-2766. [View] [PubMed]
Pubchem: 3015870

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)c2ccccc2

Level: 1

Mol. Weight: 272.3 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 272.3 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.49
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.230
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.83

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.950
Plasma Protein Binding
60.08
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.880
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.050
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.300
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.060
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.780
Rat (Acute)
2.010
Rat (Chronic Oral)
2.070
Fathead Minnow
4.840
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
359.930
Hydration Free Energy
-7.820
Log(D) at pH=7.4
3.010
Log(P)
2.73
Log S
-4.09
Log(Vapor Pressure)
-5.04
Melting Point
101.13
pKa Acid
10.24
pKa Basic
0.06
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9767
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9605
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9592
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.9512
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.9484
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.9445
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9438
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9430
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9395
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.9320
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9314
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9296
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9229
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9216
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.9196
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.9192
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.9183
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9161
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.9158
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9129
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9103
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9074
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.9024
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.9022
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8984
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8960
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8956
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8927
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8916
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8902
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8893
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8877
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8845
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8814
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8773
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8770
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8725
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8705
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8700
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.8639
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8618
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8587
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8522
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8518
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8460
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8421
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8416
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8372
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8370
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8351
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8351
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8343
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8335
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8298
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8237
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.8214
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8184
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8182
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8145
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8099
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8079
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8059
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8050
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8019
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7987
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7936
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7933
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7933
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7924
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7921
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7910
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7904
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7903
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7901
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7890
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7877
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7853
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7813
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7809
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7800
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7798
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7798
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7796
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7793
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7789
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7781
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7756
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7749
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7721
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7719
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7717
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7717
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7717
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7716
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7711
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7687
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 4 0.7681
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7680
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7672
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7672
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7672
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7668
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7668
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7659
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7658
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7642
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7636
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7636
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7635
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7632
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7619
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7614
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7610
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7599
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7598
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7592
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7590
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7582
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7576
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7573
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 2 0.7569
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7566
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7545
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7544
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7539
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7539
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7533
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7530
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7524
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7514
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7509
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7502
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7495
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7494
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7494
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7493
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7485
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7474
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7473
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7467
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7461
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7461
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7459
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7452
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7450
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7410
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7398
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7394
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7389
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7388
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7387
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7387
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7386
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7385
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7380
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7380
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7375
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7374
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7371
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7367
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7365
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7362
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7360
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7355
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7351
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7339
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7339
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7337
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7333
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7327
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7324
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7323
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7321
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7320
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7317
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 2 0.7314
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7313
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7310
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7302
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7294
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7291
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7291
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7287
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7280
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7277
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7268
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7259
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7255
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7249
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7246
Catabolite activator protein C3SQJ7 C3SQJ7_ECOLX Escherichia coli 3 0.7234
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7233
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7227
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7224
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7214
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7213
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7207
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 2 0.7201
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7200
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.7199
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7199
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7195
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7193
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7192
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7190
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7189
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7188
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7186
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7184
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7178
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7178
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7176
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7175
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7175
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7169
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7160
Deoxyribodipyrimidine photo-lyase Q8PYK9 Q8PYK9_METMA Methanosarcina mazei 4 0.7158
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7153
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7152
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7147
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7147
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7142
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7140
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7138
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7127
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7122
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7119
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7119
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 2 0.7116
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7106
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7103
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 2 0.7102
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7099
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7097
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7096
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 2 0.7092
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7092
Phospholipase A2, membrane associated P14555 PA2GA_HUMAN Homo sapiens 2 0.7088
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7085
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7081
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7081
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7080
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7078
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7077
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7075
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7074
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7074
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7074
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7073
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7069
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7064
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7062
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 2 0.7060
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7058
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7057
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7055
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7047
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 2 0.7045
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7040
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7038
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7031
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7026
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7018
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7017
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7010
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7007
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7004
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7003

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