10-methoxycanthin-6-one - Compound Card

10-methoxycanthin-6-one

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10-methoxycanthin-6-one

Structure
Zoomed Structure
  • Family: Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Phenanthridine Alkaloid
Canonical Smiles COc1ccc2c(c1)c1ccnc3c1n2c(=O)cc3
InChI InChI=1S/C15H10N2O2/c1-19-9-2-4-13-11(8-9)10-6-7-16-12-3-5-14(18)17(13)15(10)12/h2-8H,1H3
InChIKey FDBMONUDUKGKGY-UHFFFAOYSA-N
Formula C15H10N2O2
HBA 4
HBD 0
MW 250.26
Rotatable Bonds 1
TPSA 43.6
LogP 2.45
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 250.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Zanthoxylum paracanthum Rutaceae Plantae 2695424

Showing of synonyms

  • Kaigongi MM, Lukhoba CW, et al. (2020). In Vitro Antimicrobial and Antiproliferative Activities of the Root Bark Extract and Isolated Chemical Constituents of Zanthoxylum paracanthum Kokwaro (Rutaceae). Plants (Basel). 2020 , 9(7),920. [View] [PubMed]
Pubchem: 158928
Nmrshiftdb2: 20146935
CPRiL: 426152
Structure

SMILES: c1cccc(c1c23)n4c2c(ccc4=O)ncc3

Level: 0

Mol. Weight: 220.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.76
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.960
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.83

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.300
Plasma Protein Binding
75.65
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.280
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.720
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.440
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.170
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Toxic
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.000
Rat (Acute)
2.140
Rat (Chronic Oral)
1.360
Fathead Minnow
4.680
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Toxic
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
476.860
Hydration Free Energy
-13.600
Log(D) at pH=7.4
2.150
Log(P)
2.24
Log S
-4.89
Log(Vapor Pressure)
-6.88
Melting Point
244.73
pKa Acid
10.81
pKa Basic
5.41
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9825
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.9695
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9601
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9578
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9557
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9441
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.9352
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.9217
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.9203
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.9141
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9029
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.9018
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8916
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8903
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8895
Acidic mammalian chitinase Q9BZP6 CHIA_HUMAN Homo sapiens 3 0.8862
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8815
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8814
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8812
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8791
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8776
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8762
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8698
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8698
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8561
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8556
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8508
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8503
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8474
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8469
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8464
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8457
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8456
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.8405
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8374
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8334
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8310
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8305
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8284
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8266
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8236
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8220
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.8147
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.8142
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8140
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8118
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8075
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8054
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8037
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.8023
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8011
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8002
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7994
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7985
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7973
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7971
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7951
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7950
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7941
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7938
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 3 0.7930
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7923
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7910
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7883
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7880
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7846
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7836
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7813
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7799
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7775
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7765
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7753
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7729
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7683
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7683
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7680
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7677
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7671
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7665
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7662
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7649
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7642
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7636
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7618
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7614
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7612
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7611
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7606
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7605
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.7605
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7604
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7601
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7587
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7586
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7579
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7566
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7556
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7553
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7552
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7547
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7499
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7491
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7486
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7484
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7481
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7464
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7463
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7456
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7444
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7436
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7425
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7417
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7416
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7412
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7411
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7393
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7392
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7391
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 3 0.7388
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7359
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7330
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7327
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7323
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7319
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.7308
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7299
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7297
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7292
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7283
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7279
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7278
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7263
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7260
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7253
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7242
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7237
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7227
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7226
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7223
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7222
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7212
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7210
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7201
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7200
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7198
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7195
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7193
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7191
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7188
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7187
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7187
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7185
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7184
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7180
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7180
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7171
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7157
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7156
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7155
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7151
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7149
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7142
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7138
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7135
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7129
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7121
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7120
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7114
Tryptophan--tRNA ligase, cytoplasmic Q12109 SYWC_YEAST Saccharomyces cerevisiae 3 0.7107
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7104
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7098
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7091
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7086
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7078
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7074
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7066
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7051
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7050
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7043
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7037
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7035
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 2 0.7033
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7030
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7028
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7027
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7021
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7016
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7011
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7001

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