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(epi)catechin-(epi)catechin

Family: Plantae - Ximeniaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavanol

Canonical Smiles	C1([C@H](Cc2c(O)cc(O)cc2O1)Oc1cc(c2C[C@@H](C(Oc2c1)c1cc(O)c(O)cc1)O)O)c1cc(O)c(O)cc1
InChI	InChI=1S/C30H26O11/c31-15-7-21(34)18-12-28(30(41-26(18)8-15)14-2-4-20(33)24(37)6-14)39-16-9-22(35)17-11-25(38)29(40-27(17)10-16)13-1-3-19(32)23(36)5-13/h1-10,25,28-38H,11-12H2/t25-,28-,29?,30?/m0/s1
InChIKey	HBTUISCFTIMBGA-XLVGPZCLSA-N
Formula	C₃₀H₂₆O₁₁
HBA	11
HBD	8
MW	562.53
Rotatable Bonds	4
TPSA	189.53
LogP	3.79
Number Rings	6
Number Aromatic Rings	4
Heavy Atom Count	41
Formal Charge	0
Fraction CSP3	0.2
Exact Mass	562.15
Number of Lipinski Rule Violations	3

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ximenia americana	Ximeniaceae	Plantae	50174

Showing of synonyms

Sobeh M, Mahmoud MF, et al. (2017). Hepatoprotective and hypoglycemic effects of a tannin rich extract from Ximenia americana var. caffra root. Phytomedicine : international journal of phytotherapy and phytopharmacology,2017, 33(), 36-42. [View] [PubMed]

No compound-protein relationship available.

SMILES: c1cccc(c12)OC(c3ccccc3)C(C2)Oc(cc4)cc(c45)OC(CC5)c6ccccc6

Level: 3

Mol. Weight: 562.53 g/mol

SMILES: c1cccc(c12)OCC(C2)Oc(cc3)cc(c34)OC(CC4)c5ccccc5

Level: 2

Mol. Weight: 562.53 g/mol

SMILES: c1cccc(c12)OC(c3ccccc3)C(C2)Oc(cc4)cc(c45)OCCC5

Level: 2

Mol. Weight: 562.53 g/mol

SMILES: c1cccc(c12)OCC(C2)Oc(cc3)cc(c34)OCCC4

Level: 1

Mol. Weight: 562.53 g/mol

SMILES: c1cccc(c12)OC(CC2)c3ccccc3

Level: 1

Mol. Weight: 562.53 g/mol

SMILES: C1CCOc(c12)cccc2

Level: 0

Mol. Weight: 562.53 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 562.53 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -6.65
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Non-Absorbed
Madin-Darby Canine Kidney: -5.11
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 5.37

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.98
Plasma Protein Binding: 77.86
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 11.78
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.08
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.42
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.44
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -8514.01
Rat (Acute): 2.28
Rat (Chronic Oral): 3.05
Fathead Minnow: 23.46
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 535.72
Hydration Free Energy: -3.16
Log(D) at pH=7.4: 2.48
Log(P): 2.74
Log S: -5.16
Log(Vapor Pressure): -11.22
Melting Point: 294.4
pKa Acid: 6.89
pKa Basic: 7.68

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9489
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9261
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9094
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.9054
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.9049
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9035
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8936
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8893
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	3	0.8876
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.8829
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8804
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8766
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8763
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	4	0.8747
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8740
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8713
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8699
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8667
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8617
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8589
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8527
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8518
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8428
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8406
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.8396
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8384
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	4	0.8367
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.8357
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8354
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8352
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	6	0.8351
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8342
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8339
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8336
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	5	0.8316
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8308
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8298
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8297
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8292
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8280
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.8261
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8260
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8252
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8235
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8231
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	4	0.8226
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8172
Virulence sensor histidine kinase PhoQ	P0DM80	PHOQ_SALTY	Salmonella typhimurium	4	0.8151
Beta-glucosidase 1A	Q25BW5	BGL1A_PHACH	Phanerodontia chrysosporium	3	0.8144
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8133
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8129
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8123
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8117
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8112
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.8094
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8085
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8085
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8066
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8060
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.8026
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8022
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.8019
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7992
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7977
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7975
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7965
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7955
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.7947
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7931
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7902
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7865
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7851
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.7831
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7829
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7822
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7809
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7808
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.7806
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7806
Thymidylate kinase	Q8I4S1	Q8I4S1_PLAF7	Plasmodium falciparum	5	0.7800
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7798
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7786
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7772
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7745
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7726
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7722
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7709
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7697
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7691
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7686
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7685
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7685
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7675
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7672
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7671
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7647
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7645
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	3	0.7631
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	5	0.7626
Heat shock protein 75 kDa, mitochondrial	Q12931	TRAP1_HUMAN	Homo sapiens	4	0.7623
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7609
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7607
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7584
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.7582
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7577
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7573
Geranylgeranyl transferase type-2 subunit alpha	Q08602	PGTA_RAT	Rattus norvegicus	3	0.7566
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7551
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7539
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7538
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7504
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	4	0.7494
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7484
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7481
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7477
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7454
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7447
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	4	0.7441
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7436
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7432
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.7430
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7425
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7419
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.7416
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7413
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7410
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7399
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7367
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	4	0.7355
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7348
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7332
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7330
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7330
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	4	0.7314
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7296
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7285
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7282
Tubulin--tyrosine ligase	F6Z895	A9ULH4_XENTR	Xenopus tropicalis	4	0.7269
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7269
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7269
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7262
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7257
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7254
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7241
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7239
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.7227
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	4	0.7224
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	4	0.7220
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7219
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7211
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7205
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7202
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7201
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7200
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7200
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7192
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7191
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7180
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7173
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.7169
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7168
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7165
DNA-(apurinic or apyrimidinic site) lyase	Q97FM4	Q97FM4_CLOAB	Clostridium acetobutylicum	4	0.7162
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P49354	FNTA_HUMAN	Homo sapiens	3	0.7152
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7145
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7144
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7140
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7136
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7134
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.7129
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7127
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7123
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7120
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	4	0.7110
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7104
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	3	0.7099
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7093
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7091
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	3	0.7087
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7087
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7076
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7073
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7070
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7062
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7057
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7053
chitinase	B0Y2Y2	B0Y2Y2_ASPFC	Aspergillus fumigatus	4	0.7050
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7045
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7045
Small heat shock protein StHsp14.0	Q970D9	Q970D9_SULTO	Sulfurisphaera tokodaii	3	0.7034
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7033
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7033
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7025
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7021
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.7004
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7002
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7001

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