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S-(-)-N-trans-feruloyl normetanephrine

Family: Amaranthaceae, Chenopodiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Lignanamide

Canonical Smiles	COc1cc(/C=C/C(=O)NC[C@H](c2ccc(c(c2)OC)O)O)ccc1O
InChI	InChI=1S/C19H21NO6/c1-25-17-9-12(3-6-14(17)21)4-8-19(24)20-11-16(23)13-5-7-15(22)18(10-13)26-2/h3-10,16,21-23H,11H2,1-2H3,(H,20,24)/b8-4+/t16-/m1/s1
InChIKey	UTMBJMONAMBFJU-KZJSRBBCSA-N
Formula	C₁₉H₂₁NO₆
HBA	6
HBD	4
MW	359.38
Rotatable Bonds	7
TPSA	108.25
LogP	1.98
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	26
Formal Charge	0
Fraction CSP3	0.21
Exact Mass	359.14
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Bassia indica	Amaranthaceae	Plantae	267517
2	Bassia indica	Chenopodiaceae	Plantae	267517

Showing of synonyms

Othman A, Amen Y, et al. (2022). Bassiamide A, a new alkaloid from xero-halophyte Bassia indica Wight. Nat Prod Res, 2022, 36(14), 3610-3618.. [View] [PubMed]

Pubchem: 102169551

Cas: 2705170-78-9

No compound-protein relationship available.

SMILES: c1ccccc1C=CC(=O)NCCc2ccccc2

Level: 1

Mol. Weight: 251.33 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.94
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.060
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.07

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.890
Plasma Protein Binding: 55.14
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 10.310
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.630
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.850
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.770
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -1.910
Rat (Acute): 1.910
Rat (Chronic Oral): 2.960
Fathead Minnow: 4.290
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 456.910
Hydration Free Energy: -11.620
Log(D) at pH=7.4: 2.030
Log(P): 0.95
Log S: -3.85
Log(Vapor Pressure): -8.02
Melting Point: 169.62
pKa Acid: 8.19
pKa Basic: 3.88

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9691
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.9670
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9516
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9466
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9446
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9367
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.9326
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9312
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9291
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9241
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.9104
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.9078
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9048
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8991
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8976
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8974
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8944
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.8931
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8914
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8904
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8896
16S rRNA (adenine(1408)-N(1))-methyltransferase	A8C927	NPMA_ECOLX	Escherichia coli	4	0.8879
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8825
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8818
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.8808
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8802
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8799
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8773
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.8759
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.8699
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.8698
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8692
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8689
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8670
Caffeic acid O-methyltransferase	Q9ZTU2	Q9ZTU2_LOLPR	Lolium perenne	4	0.8646
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8582
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8567
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8547
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8546
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8542
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8535
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8520
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8507
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.8506
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.8505
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8497
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.8442
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8438
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	3	0.8438
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8431
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8424
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8396
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8394
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8381
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8378
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8373
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8370
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8357
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8332
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8332
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8311
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8303
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8281
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8258
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8256
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.8254
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.8253
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8252
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8252
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	3	0.8166
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8141
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8130
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8128
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8122
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.8112
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.8104
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8099
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.8061
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8060
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8033
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8033
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.8023
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.7983
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.7972
Coniferyl alcohol 9-O-methyltransferase	A6XNE6	A6XNE6_9ROSI	Linum nodiflorum	3	0.7964
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7960
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7954
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.7950
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7943
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7932
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7922
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.7901
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7899
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7897
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7895
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7884
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7877
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7845
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7845
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	4	0.7844
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7827
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7820
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7815
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	4	0.7805
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7801
tRNA (cytidine-2'-O-)-methyltransferase TrmJ	Q4JB16	TRMJ_SULAC	Sulfolobus acidocaldarius	4	0.7798
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7785
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7784
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7782
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7775
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7765
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7760
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7760
Tubulin--tyrosine ligase	F6Z895	A9ULH4_XENTR	Xenopus tropicalis	4	0.7745
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7721
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7714
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7701
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7700
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7691
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7681
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	4	0.7669
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7669
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7666
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7665
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7664
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7659
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7658
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7658
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	3	0.7649
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7649
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7646
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7641
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7632
Beta-glucosidase 1A	Q25BW5	BGL1A_PHACH	Phanerodontia chrysosporium	3	0.7616
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7612
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7612
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7608
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.7604
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.7603
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7600
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.7593
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7590
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7586
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7584
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7582
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.7581
7-methylguanosine phosphate-specific 5'-nucleotidase	Q9W197	5NT3B_DROME	Drosophila melanogaster	3	0.7572
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	3	0.7570
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7559
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7559
Histone-lysine N-methyltransferase KMT5C	Q6Q783	KMT5C_MOUSE	Mus musculus	4	0.7557
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7556
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	4	0.7553
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7553
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	5	0.7547
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7543
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7541
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7533
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7533
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7531
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7531
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	4	0.7530
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	4	0.7529
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7526
Eukaryotic translation initiation factor 4E-1	P29557	IF4E1_WHEAT	Triticum aestivum	4	0.7520
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7509
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7509
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7508
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.7504
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7503
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7500
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7497
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.7493
DNA-(apurinic or apyrimidinic site) lyase	Q97FM4	Q97FM4_CLOAB	Clostridium acetobutylicum	4	0.7485
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7484
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7468
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7466
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.7465
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	4	0.7461
3',5'-cyclic-AMP phosphodiesterase 4B	Q07343	PDE4B_HUMAN	Homo sapiens	3	0.7458
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7452
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7447
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7445
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7445
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7434
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7434
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7431
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7430
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7419
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7418
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7411
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7409
N-acetylhexosamine 1-kinase	E8MF12	NAHK_BIFL2	Bifidobacterium longum subsp. longum	3	0.7407
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7401
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7401
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7398
Lipoyl synthase 2	Q8DLC2	LIPA2_THEEB	Thermosynechococcus vestitus	4	0.7390
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7390
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7389
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7383
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7380
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	4	0.7379
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	4	0.7378
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7376
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7374
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7371
Repressor protein	Q7X0D9	Q7X0D9_ACIAD	Acinetobacter baylyi	3	0.7354
Glycogenin-1	P46976	GLYG_HUMAN	Homo sapiens	3	0.7353
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7349
Threonine--tRNA ligase	P0A8M3	SYT_ECOLI	Escherichia coli	3	0.7347
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7345
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7345
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7343
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7333
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7328
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7324
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7319
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7317
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7315
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7314
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7314
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7313
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7310
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7306
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7305
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7304
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7303
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7303
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7300
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7299
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7284
Histone-lysine N-methyltransferase EHMT2	Q96KQ7	EHMT2_HUMAN	Homo sapiens	3	0.7279
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4	Q8GZB6	SUVH4_ARATH	Arabidopsis thaliana	3	0.7278
Laminarinase	Q9WXN1	Q9WXN1_THEMA	Thermotoga maritima	3	0.7275
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7274
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7271
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7262
Tryptophan--tRNA ligase	Q9PIB4	SYW_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	4	0.7261
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7259
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	3	0.7258
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	5	0.7256
Histone-lysine N-methyltransferase 2A	Q03164	KMT2A_HUMAN	Homo sapiens	3	0.7256
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7254
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7253
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7246
Histone-lysine N-methyltransferase 2C	Q8NEZ4	KMT2C_HUMAN	Homo sapiens	3	0.7240
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7240
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7240
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7239
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7236
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	4	0.7233
Calmodulin-like domain protein kinase	Q3HNM4	Q3HNM4_EIMTE	Eimeria tenella	4	0.7229
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7224
N-glycosylase/DNA lyase	O15527	OGG1_HUMAN	Homo sapiens	4	0.7224
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7223
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7220
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	4	0.7217
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7216
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7213
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7212
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	3	0.7211
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7209
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7204
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7203
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7202
DNA (cytosine-5)-methyltransferase 3A	O88508	DNM3A_MOUSE	Mus musculus	3	0.7195
chitinase	B0Y2Y2	B0Y2Y2_ASPFC	Aspergillus fumigatus	3	0.7195
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7181
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7179
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7178
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7177
Formylmethanofuran--tetrahydromethanopterin formyltransferase	Q49610	FTR_METKA	Methanopyrus kandleri	3	0.7174
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7172
Riboflavin biosynthesis protein	Q9WZW1	Q9WZW1_THEMA	Thermotoga maritima	4	0.7171
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7170
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7169
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7169
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	3	0.7168
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7167
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	2	0.7161
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	3	0.7159
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7157
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7156
SRSF protein kinase 1	Q96SB4	SRPK1_HUMAN	Homo sapiens	3	0.7155
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7152
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7151
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7149
Protein mono-ADP-ribosyltransferase PARP14	Q460N5	PAR14_HUMAN	Homo sapiens	3	0.7140
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7137
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7137
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7136
Transitional endoplasmic reticulum ATPase	P55072	TERA_HUMAN	Homo sapiens	3	0.7134
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7129
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7128
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7127
Histone-lysine N-methyltransferase 2A	Q03164	KMT2A_HUMAN	Homo sapiens	3	0.7121
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7119
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7119
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7117
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7117
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7116
Nuclear receptor subfamily 5 group A member 2	O00482	NR5A2_HUMAN	Homo sapiens	3	0.7115
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7113
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7110
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7110
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7107
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7107
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7106
Aspartate aminotransferase	P00509	AAT_ECOLI	Escherichia coli	2	0.7104
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7103
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7102
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7100
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7100
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7099
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7093
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7091
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7089
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7088
Release factor glutamine methyltransferase	Q9WYV8	PRMC_THEMA	Thermotoga maritima	3	0.7087
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7086
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7085
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7084
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7082
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7077
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7073
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.7070
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	3	0.7069
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7062
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7055
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.7055
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7052
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7050
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7049
Ras-related C3 botulinum toxin substrate 3	P60763	RAC3_HUMAN	Homo sapiens	4	0.7048
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7046
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7046
UTP-monosaccharide-1-phosphate uridylyltransferase	D3G6S4	D3G6S4_LEIMA	Leishmania major	3	0.7044
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7044
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7039
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7038
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7036
LD-carboxypeptidase	A0A6L8PVW7	A0A1Q4LWC0_BACAN	Bacillus anthracis	3	0.7035
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7034
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7034
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	3	0.7033
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7032
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7032
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7032
Chromosome partitioning protein ParA	B0ZE06	B0ZE06_ECOLX	Escherichia coli	3	0.7031
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7031
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7025
Kynurenine--oxoglutarate transaminase 1	Q16773	KAT1_HUMAN	Homo sapiens	2	0.7022
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7021
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7020
Benzoylformate decarboxylase	P20906	MDLC_PSEPU	Pseudomonas putida	3	0.7020
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7019
Deacetoxycephalosporin C synthase	P18548	CEFE_STRCL	Streptomyces clavuligerus	2	0.7018
Aspartate carbamoyltransferase catalytic subunit	P0A786	PYRB_ECOLI	Escherichia coli	3	0.7015
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7012
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7010
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7007
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7001
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7000

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