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S-(-)-N-trans-feruloyl octopamine

Family: Plantae - Amaranthaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Lignanamide

Canonical Smiles	O=C(NC[C@H](c1ccc(cc1)O)O)/C=C/c1ccc(c(c1)O)O
InChI	InChI=1S/C17H17NO5/c19-13-5-3-12(4-6-13)16(22)10-18-17(23)8-2-11-1-7-14(20)15(21)9-11/h1-9,16,19-22H,10H2,(H,18,23)/b8-2+/t16-/m1/s1
InChIKey	WFSBMHVPEBWUPR-FQCWITJCSA-N
Formula	C₁₇H₁₇NO₅
HBA	5
HBD	5
MW	315.33
Rotatable Bonds	5
TPSA	110.02
LogP	1.67
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	23
Formal Charge	0
Fraction CSP3	0.12
Exact Mass	315.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Bassia indica	Amaranthaceae	Plantae	267517

Showing of synonyms

Othman A, Amen Y, et al. (2022). Bassiamide A, a new alkaloid from xero-halophyte Bassia indica Wight. Nat Prod Res, 2022, 36(14), 3610-3618.. [View] [PubMed]

Pubchem: 11438436

No compound-protein relationship available.

SMILES: c1ccccc1C=CC(=O)NCCc2ccccc2

Level: 1

Mol. Weight: 315.33 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 315.33 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.48
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.04
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.76

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.68
Plasma Protein Binding: 57.56
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 10.01
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -0.36
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.41
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 3.69
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 0.95
Rat (Acute): 2.18
Rat (Chronic Oral): 3.26
Fathead Minnow: 4.11
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 484.3
Hydration Free Energy: -14.14
Log(D) at pH=7.4: 0.97
Log(P): 1.02
Log S: -2.18
Log(Vapor Pressure): -10.21
Melting Point: 226.43
pKa Acid: 7.41
pKa Basic: 5.8

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.9766
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9737
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9602
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9477
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.9439
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9369
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9356
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9324
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.9278
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9239
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9210
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.9205
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.9204
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.9174
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.9143
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.9140
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.9130
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9121
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9019
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.9005
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8958
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8952
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.8937
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.8936
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8921
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.8921
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8916
Repressor protein	Q7X0D9	Q7X0D9_ACIAD	Acinetobacter baylyi	3	0.8913
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8853
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8773
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8745
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.8728
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.8722
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.8707
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8685
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8680
Nuclear receptor subfamily 5 group A member 2	O00482	NR5A2_HUMAN	Homo sapiens	4	0.8666
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8662
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8660
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8660
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8659
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8642
Epothilone C/D epoxidase	Q9KIZ4	C167_SORCE	Sorangium cellulosum	3	0.8624
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8617
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8601
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.8543
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8534
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.8532
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.8505
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8479
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	4	0.8447
Caffeic acid O-methyltransferase	Q9ZTU2	Q9ZTU2_LOLPR	Lolium perenne	4	0.8441
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.8437
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8432
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8421
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8409
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	3	0.8404
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.8399
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8396
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.8383
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8374
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8363
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8356
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.8346
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8334
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8330
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8315
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8303
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	4	0.8293
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8290
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.8288
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8283
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8269
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.8267
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8265
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.8263
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8254
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8242
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8241
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8240
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.8234
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8217
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8210
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8186
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8182
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.8147
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8133
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8123
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8114
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.8108
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	3	0.8089
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.8062
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8052
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8032
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.8031
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	4	0.8027
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	3	0.8012
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7987
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.7968
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7937
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.7932
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7920
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7911
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.7909
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7904
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7898
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7898
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7898
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7887
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7881
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7871
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7869
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7868
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	3	0.7857
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7856
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7853
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7842
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.7824
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7816
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	3	0.7813
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7812
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7789
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7784
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7779
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7778
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	4	0.7775
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7773
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7754
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.7754
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7751
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7746
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7729
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7715
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7699
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7693
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.7688
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7688
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7687
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	4	0.7678
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7675
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.7668
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7668
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7667
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7666
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7661
Tubulin--tyrosine ligase	F6Z895	A9ULH4_XENTR	Xenopus tropicalis	4	0.7655
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7653
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7647
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	4	0.7647
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7641
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7638
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7638
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	3	0.7638
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	3	0.7635
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7630
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7618
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7601
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7600
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7592
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7579
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7578
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7576
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7574
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7571
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7570
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7564
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7539
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7539
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7538
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7538
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7536
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	P49235	HGGL1_MAIZE	Zea mays	2	0.7536
7-methylguanosine phosphate-specific 5'-nucleotidase	Q9W197	5NT3B_DROME	Drosophila melanogaster	3	0.7531
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7529
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7515
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7514
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7508
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7505
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7505
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7502
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	5	0.7497
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.7497
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7497
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7492
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7481
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7480
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7474
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7474
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7474
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7468
Ribosomal RNA small subunit methyltransferase NEP1	Q06287	NEP1_YEAST	Saccharomyces cerevisiae	4	0.7457
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7454
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7446
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7442
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7439
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7439
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7438
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7433
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7425
Peroxidase C1A	P00433	PER1A_ARMRU	Armoracia rusticana	3	0.7424
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7413
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7411
Formylmethanofuran--tetrahydromethanopterin formyltransferase	Q49610	FTR_METKA	Methanopyrus kandleri	3	0.7393
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7392
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7386
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7381
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7378
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7378
chitinase	B0Y2Y2	B0Y2Y2_ASPFC	Aspergillus fumigatus	3	0.7376
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7371
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7361
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7360
DNA-(apurinic or apyrimidinic site) lyase	Q97FM4	Q97FM4_CLOAB	Clostridium acetobutylicum	4	0.7357
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7354
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7353
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7346
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7342
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7338
Matrix metalloproteinase-20	O60882	MMP20_HUMAN	Homo sapiens	3	0.7338
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7331
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7324
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7319
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7310
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7308
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7306
Coniferyl alcohol 9-O-methyltransferase	A6XNE6	A6XNE6_9ROSI	Linum nodiflorum	3	0.7295
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7289
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7285
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7284
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7284
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7282
Poly(A) polymerase	P29468	PAP_YEAST	Saccharomyces cerevisiae	3	0.7281
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7279
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7277
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	5	0.7276
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7276
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7266
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7265
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7262
N-acetylhexosamine 1-kinase	E8MF12	NAHK_BIFL2	Bifidobacterium longum subsp. longum	3	0.7248
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7242
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	3	0.7242
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7238
Beta-galactoside-specific lectin 1	P81446	ML1_VISAL	Viscum album	3	0.7234
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7233
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7232
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7231
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7229
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7220
3',5'-cyclic-AMP phosphodiesterase 4B	Q07343	PDE4B_HUMAN	Homo sapiens	3	0.7219
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7209
Protein mono-ADP-ribosyltransferase PARP14	Q460N5	PAR14_HUMAN	Homo sapiens	3	0.7209
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7204
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7199
SRSF protein kinase 1	Q96SB4	SRPK1_HUMAN	Homo sapiens	3	0.7192
Transitional endoplasmic reticulum ATPase	P55072	TERA_HUMAN	Homo sapiens	3	0.7191
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7189
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7183
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7182
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7179
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7179
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7167
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7162
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7159
Benzoylformate decarboxylase	P20906	MDLC_PSEPU	Pseudomonas putida	3	0.7159
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	4	0.7156
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7151
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7145
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7143
Metallo-beta-lactamase type 2	P26918	BLAB_AERHY	Aeromonas hydrophila	2	0.7143
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7141
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7135
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7120
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7120
Transitional endoplasmic reticulum ATPase	Q01853	TERA_MOUSE	Mus musculus	3	0.7117
Threonine--tRNA ligase	P0A8M3	SYT_ECOLI	Escherichia coli	3	0.7114
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7113
14-3-3 protein gamma	P61981	1433G_HUMAN	Homo sapiens	3	0.7112
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase	Q9WY79	MURE_THEMA	Thermotoga maritima	3	0.7110
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7108
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7104
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.7103
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7101
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7099
Chromosome partitioning protein ParA	B0ZE06	B0ZE06_ECOLX	Escherichia coli	3	0.7098
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7098
L-seryl-tRNA(Sec) kinase	Q58933	PSTK_METJA	Methanocaldococcus jannaschii	2	0.7098
Indole-3-glycerol phosphate synthase	P9WFX7	TRPC_MYCTU	Mycobacterium tuberculosis	2	0.7098
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7096
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7093
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7085
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7078
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7078
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7076
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	4	0.7073
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7073
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.7071
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4	Q8GZB6	SUVH4_ARATH	Arabidopsis thaliana	3	0.7070
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7067
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7067
Petrobactin biosynthesis protein AsbB	Q81RQ8	Q81RQ8_BACAN	Bacillus anthracis	3	0.7067
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7066
Capsid protein VP1	O56137	O56137_9VIRU	Adeno-associated virus - 6	3	0.7065
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7058
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7057
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7055
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7053
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7048
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	3	0.7047
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7044
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7041
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7035
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7033
LD-carboxypeptidase	A0A6L8PVW7	A0A1Q4LWC0_BACAN	Bacillus anthracis	3	0.7025
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7024
Adenine DNA glycosylase	P83847	MUTY_GEOSE	Geobacillus stearothermophilus	3	0.7023
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7022
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7018
Formate--tetrahydrofolate ligase	Q2RM91	FTHS_MOOTA	Moorella thermoacetica	2	0.7018
Lipoyl synthase 2	Q8DLC2	LIPA2_THEEB	Thermosynechococcus vestitus	4	0.7013
Endoplasmic reticulum aminopeptidase 2	Q6P179	ERAP2_HUMAN	Homo sapiens	2	0.7009
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7009
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	3	0.7005

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